Basic and applied research progress of TRAIL in hematologic malignancies [0.03%]
TRAIL在血液系统恶性肿瘤基础及应用研究中的进展
Sidong Zhang,Rongqun Guo,Yufeng Liu et al.
Sidong Zhang et al.
Hematological malignancies encompass a diverse range of blood-related cancers characterized by abnormal blood cell production. These cancers, classified by the World Health Organization based on lineage, cell origin, and progression, provid...
Snehil Kumar,Faiq Ahmed,Manasi Mundada et al.
Snehil Kumar et al.
Chong Yang,Toshio Suda
Chong Yang
Anemia is a condition marked by a shortage of red blood cells or hemoglobin, resulting in a diminished ability of the blood to carry oxygen. In response to anemia or hypoxia, the body activates a compensatory mechanism known as stress eryth...
Enhancing hemophilia A gene therapy by strategic F8 deletions in AAV vectors [0.03%]
通过AAV载体中F8的战略性缺失来提高血友病A的基因治疗效果
Juan-Juan Zhao,Sai-Ning Tian,Xiang Li et al.
Juan-Juan Zhao et al.
Hemophilia A, caused by a deficiency in factor VIII (F8), is a promising target for gene therapy. This study aims to enhance the efficacy of adeno-associated virus serotype 8 (AAV8) vectors, specifically those encoding B-domain-deleted F8 (...
Decitabine facilitates thrombopoiesis independent of the thrombopoietin receptor in zebrafish [0.03%]
地西他滨在斑马鱼中促进与血小板生成素受体无关的血小板生成
Yudong Chen,Liangliang Wu,Lian Yang et al.
Yudong Chen et al.
In vitro erythropoiesis: the emerging potential of induced pluripotent stem cells (iPSCs) [0.03%]
体外红细胞生成：诱导多能干细胞(iPSCs)的新兴潜力
Chidera G Chukwuemeka,Chizaram W Ndubueze,Adeola V Kolawole et al.
Chidera G Chukwuemeka et al.
Due to global blood shortages and restricted donor blood storage, the focus has switched to the in vitro synthesis of red blood cells (RBCs) from induced pluripotent stem cells (iPSCs) as a potential solution. Many processes are required to...
The inhibitory impact of various total body irradiation doses on the hematopoietic system of mice [0.03%]
各种全身照射剂量对小鼠造血系统抑制作用的比较研究
Hui Xu,Jinwang Zhang,Hexiao Zhang et al.
Hui Xu et al.
Irradiation with X-rays has been widely utilized in the clinical treatment of solid tumors and certain hematopoietic malignancies. However, this method fails to completely distinguish between malignant and normal cells. Prolonged or repeate...
γδ T cells in hematological malignancies: mechanisms and therapeutic strategies [0.03%]
血液系统恶性肿瘤中的γδT细胞：机制和治疗策略
Xingchi Chen,Guangyu Sun,Xiaoyu Zhu
Xingchi Chen
γδ T cells are a unique subset of lymphocytes with both innate and adaptive features. They recognize and eradicate various hematological malignancies through different mechanisms, employing factors including γδ TCR, NKR, NKG2D, TRAIL, a...
Daosong Wang,Jiayi Xie,Meng Zhao
Daosong Wang
Megakaryocytes (MKs) constitute a small portion of bone marrow cells and are primarily responsible for producing platelets, which are essential for hemostasis and wound healing. Recent studies have revealed that MKs and platelets perform di...
Hui Cheng
Hui Cheng