Integrated genomic analyses identify high-risk factors and actionable targets in T-cell acute lymphoblastic leukemia [0.03%]
整合型基因组分析鉴定出T细胞急性淋巴细胞白血病的高危因素及治疗靶标
Haichuan Zhu,Bingjie Dong,Yingchi Zhang et al.
Haichuan Zhu et al.
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy often associated with poor outcomes. To identify high-risk factors and potential actionable targets for T-ALL, we perform integrated genomic and transcripto...
Mature plasmacytoid dendritic cells associated with acute myeloid leukemia show similar genetic mutations and expression profiles to leukemia cells [0.03%]
与急性髓系白血病相关的成熟浆细胞样树突状细胞表现出与白血病细胞相似的遗传突变和表达谱特征
Xiaoyuan Gong,Chunhong Li,Ying Wang et al.
Xiaoyuan Gong et al.
Introduction: Mature plasmacytoid dendritic cells (pDCs) proliferation associated with myeloid neoplasms (MPDMN) are recognized as a neoplasm related to fully differentiated pDCs. Although it has been reported for many ye...
Tcf12 balances the reconstitution and differentiation capacity of hematopoietic stem cell [0.03%]
Tcf12平衡造血干细胞的重建和分化能力
Min Liao,Jianwei Wang
Min Liao
Tcf12 has been identified as one of the main helix-loop-helix transcription factors that regulates T cell development from double negative to double positive stage transition. While, the function of Tcf12 in hematopoietic stem cells remains...
Novel diagnostic approaches for Fanconi anemia (FA) by single-cell sequencing and capillary nano-immunoassay [0.03%]
单细胞测序和毛细血管纳米免疫测定在Fanconi贫血（FA）诊断中的新应用
Lixian Chang,Xingjie Gao,Guangzhen Ji et al.
Lixian Chang et al.
Next-generation sequencing technology has been widely utilized for the diagnosis of Fanconi anemia (FA). However, mixed cell sequencing and chimerism of FA patients may lead to unconfirmed genetic subtypes. Herein, we introduced two novel d...
Hanqing He,Jianwei Wang
Hanqing He
Hematopoietic stem cells (HSCs) replenish all lineages of blood cells throughout the lifespan. During aging, the repopulation capacity of HSCs declined, and aged HSCs display a tendency for myeloid differentiation. Several intrinsic and ext...
Bone marrow mesenchymal cells: polymorphism associated with transformation of rough endoplasmic reticulum [0.03%]
骨髓间质细胞：与粗面内质网转化相关的多形性
Yong-Xin Ru,Shu-Xu Dong,Chun-Hui Xu et al.
Yong-Xin Ru et al.
To understand the behavior and function of bone-marrow mesenchymal cells (BMMCs), we overviewed the morphological presentation of BMMCs in bone-marrow granules (b-BMMCs), isolated BMMCs (i-BMMCs), and BMMCs (c-BMMCs) cultured in H4434 methy...
Erratum: Ultrastructural alterations of megakaryocytes in thrombocytopenia: A review of 43 cases [0.03%]
更正:血小板减少症中巨核细胞 ultrastructure 异常的评估:43 例回顾性分析
[This corrects the article DOI: 10.1097/BS9.0000000000000093.]. Copyright © 2022 The Authors. Published by Wolters Kluwer Health Inc., on behalf of the ...
Published Erratum
Blood science (Baltimore, Md.). 2022 Feb 15;4(1):47. DOI:10.1097/BS9.0000000000000096 2022
Youli Zu
Youli Zu
Oligonucleotide aptamers are a class of small-molecule ligands. Functionally similar to protein antibodies, aptamers can specifically bind to their targets with high affinity. Biomedical studies have revealed the potential clinical value of...