ITP, easy as EBV: a rare case of severe immune thrombocytopenic purpura secondary to Epstein-Barr virus [0.03%]
EB病毒继发的严重免疫性血小板减少症的罕见案例：EB病毒导致免疫性血小板减少综合征(ITP)病例报告
Christopher Simon Hanna,Ramzi Hamouche,Shea-Lee Godin et al.
Christopher Simon Hanna et al.
Zanubrutinib enhances CD19 CAR T killing of B-cell lymphoma by inhibiting BTK phosphorylation, regulating PI3K/AKT/mTOR pathway, and promoting autophagy [0.03%]
赞布替尼通过抑制BTK磷酸化、调节PI3K/AKT/mTOR途径和促进自噬来增强CD19 CAR T对B细胞淋巴瘤的杀伤作用
Hao Yao,Ling Qiu,Shi-Hui Ren et al.
Hao Yao et al.
Anti-CD19 chimeric antigen receptor T cells (CAR T) still have many limitations, including insufficient clinical efficacy. Zanubrutinib is a second-generation Bruton tyrosine kinase (BTK) inhibitor with higher drug potency, and it is not cl...
Application of next-generation sequencing in the treatment of myelodysplastic syndrome: from mechanisms to clinical practice [0.03%]
下一代测序技术在骨髓增生异常综合征治疗中的应用：从机制到临床实践
Ying-Ying Ma,Cheng Zhang,Ying Chen et al.
Ying-Ying Ma et al.
Myelodysplastic syndrome (MDS) is a malignant clonal disorder originating from hematopoietic stem and progenitor cells and is characterized by ineffective hematopoiesis and a high propensity for transformation into acute leukemia. Research ...
Identification of two novel TP53 mutations in secondary acute myeloid leukemia following multiple myeloma: a case report [0.03%]
继发性急性髓系白血病伴两个新型TP53突变的病例报告——多发性骨髓瘤后的并发症
Maria Antonia De Francesco,Rossella Ribolla,Alessandra Sottini et al.
Maria Antonia De Francesco et al.
Mengke Zhang,Changya Chen
Mengke Zhang
Single-cell chromatin accessibility analysis enables high-resolution dissection of regulatory elements and gene regulatory mechanisms. However, standardized and comprehensive analysis workflows remain limited. In this study, we present a st...
Anti-thymocyte globulin-resistant CD4+ memory T cells contribute to haplo-fever after allogeneic hematopoietic stem cell transplantation [0.03%]
抗胸腺细胞球蛋白耐药的CD4+记忆T细胞参与allo-发热性疾病后异基因造血干细胞移植
Huihong Huang,Ting Lu,Honglin Duan et al.
Huihong Huang et al.
Haplo-fever (HF) is a form of non-infectious fever that occurs shortly after haploidentical (HID) hematopoietic stem cell transplantation (HSCT). Its clinical significance, risk factors, and pathophysiology, particularly in the context of a...
Novel gene variants in a rare case of SRY-negative 46, XX male syndrome with bone marrow failure by whole exome sequencing [0.03%]
全外显子组测序发现的一种罕见SRY阴性46,XX男性综合征病例中的新型基因变异
Aoli Zhang,Lipeng Liu,Min Ruan et al.
Aoli Zhang et al.
The tumor microenvironment in hematologic malignancies: immune evasion, metabolic reprogramming, and therapeutic resistance [0.03%]
血液系统恶性肿瘤中的肿瘤微环境：免疫逃逸、代谢重组和治疗耐药性
Menattullah Walid,Muhammad Saboor,Shafiul Haque et al.
Menattullah Walid et al.
Hematological malignancies, including leukemia, lymphoma, and multiple myeloma, develop within and remain dependent on a complex and dynamic tumor microenvironment (TME). Malignant cells interact continuously with the cellular and molecular...
Netupitant/palonosetron is effective for preventing chemotherapy-induced nausea and vomiting in high-dose melphalan conditioning before autologous stem cell transplantation: A real-world analysis [0.03%]
奈妥彼坦/帕洛诺司琼预防自体干细胞移植前大剂量美法仑预处理期化疗引起的恶心呕吐：真实世界研究分析
Le-Qing Cao,Jing Dai,Ting Wang et al.
Le-Qing Cao et al.
High-dose melphalan (HDM) is the standard conditioning regimen before autologous stem cell transplantation (ASCT) in plasma cell malignancies. Despite prophylactic antiemetics, chemotherapy-induced nausea and vomiting (CINV) remains a preva...