Large-scale proteomic and phosphoproteomic analysis of erythroid enucleation and maturation [0.03%]
红细胞脱核成熟的大规模蛋白质组和磷酸化蛋白质组分析
Yuanliang Peng,Liming Zhu,Min Duan et al.
Yuanliang Peng et al.
Late-onset radiation-induced brain necrosis following allogeneic transplantation for CNS-involved acute myeloid leukemia after whole brain irradiation: two case reports [0.03%]
全脑放疗后异基因移植治疗中枢神经系统累及的急性髓系白血病晚期发生放射性脑坏死：2例报告
Jotaro Yamamoto,Shinsuke Takagi,Yuki Shimizu et al.
Jotaro Yamamoto et al.
Single-cell transcriptomic dissection of two waves of endothelial-hematopoietic transition in a murine yolk sac [0.03%]
小鼠卵黄囊内皮细胞向造血干细胞转换的单细胞转录组图谱分析
Zhe Chen,Chaojie Wang,Xupeng Chen et al.
Zhe Chen et al.
The yolk sac drives vertebrate embryonic hematopoiesis through primitive hematopoiesis and endothelial-to-hematopoietic transition (EHT) waves. However, dynamic cellular and molecular changes during EHT of the yolk sac remain to be elucidat...
Cerebrospinal fluid profile associated with the incidence and outcomes of patients with chronic graft-versus-host disease after haploidentical hematopoietic stem cell transplantation [0.03%]
半相合造血干细胞移植后慢性移植物抗宿主病的发生及预后与脑脊液细胞免疫表型的相关性研究
Chen Zhao,Hai-Xia Fu,Xiao-Dong Mo et al.
Chen Zhao et al.
Chronic graft-versus-host disease (cGVHD) is a major complication of haploidentical hematopoietic stem cell transplantation (haplo-HSCT). In our previous studies, we speculated that cGVHD might be closely related to immune-mediated encephal...
A drop-based workflow for fast and robust joint profiling of transcriptome and chromatin accessibility in the same cell [0.03%]
一种基于滴液的_workflow_用于同一细胞中转录组和染色质可及性联合分析的快速且稳健的方法
Ziying Yang,Siqi Liu,Changya Chen
Ziying Yang
Single-cell multiomics technologies have significantly advanced our understanding of cellular heterogeneity and biological complexity. The joint profiling of single-cell RNA sequencing (scRNA-seq) and single-cell ATAC sequencing (scATAC-seq...
Chinese guidance for the clinical application of adeno-associated virus vector-based gene therapy for hemophilia B (2025) [0.03%]
中国血友病B腺相关病毒载体基因治疗临床应用指导原则（2025年版）
Feng Xue,Yu Hu,Renchi Yang et al.
Feng Xue et al.
Currently, factor IX replacement is the mainstay treatment for hemophilia B in clinical practice. However, since the disease cannot be cured, lifelong treatment and frequent infusion is required. In recent years, hemophilia B gene therapy h...
G2B: an optimized lentiviral vector with enhanced titer and β-globin expression for improved β-thalassemia gene therapy [0.03%]
G2B：一种优化的慢病毒载体，具有增强的滴度和β-球蛋白表达，可改善β-地中海贫血基因治疗
Zhu-Ying Gao,Zhi-Xue Yang,Dong-Hao Deng et al.
Zhu-Ying Gao et al.
Gene therapy using lentiviral vectors offers a promising alternative treatment for β-thalassemia, a common monogenic blood disorder. Although the BB305 vector has demonstrated long-term clinical success-enabling most β-thalassemia patient...
Mesenchymal stem cells attenuate keloid pathogenesis via TGF-β1/SMAD-driven MMP9 suppression: mechanistic insights into collagen remodeling and extracellular matrix homeostasis [0.03%]
间充质干细胞通过TGF-β1/SMAD驱动的MMP9抑制来减轻瘢痕增生的发病机制：关于胶原重塑和细胞外基质稳态的机制见解
Yujia Zhao,Hexiao Zhang,Qiuyan Han et al.
Yujia Zhao et al.
Keloids, characterized by excessive collagen deposition and recurrence, pose significant therapeutic challenges due to limited mechanistic understanding. Mesenchymal stem cells (MSCs) exhibit potential for keloid management, but their preci...
Single-cell profiling of long non-coding RNAs in the hematopoietic system [0.03%]
血液系统长非编码RNA单细胞谱系追踪及功能研究
Yu Zhang,Qiuju Huang,Yawen Zhang et al.
Yu Zhang et al.
Long non-coding RNAs (lncRNAs) play a crucial role in normal and dysregulated hematopoiesis. However, the functional repertoire of lncRNAs across various hematopoietic cell types remains elusive. In this study, we constructed a comprehensiv...