Febrile neutropenia adversely affects chemomobilization outcomes in patients with multiple myeloma and increases risk for post-transplant infection in those with lymphoma: real-world multicenter data [0.03%]
发热性中性粒细胞减少影响多发性骨髓瘤患者的化疗动员效果并增加淋巴瘤患者移植后的感染风险：真实世界多中心数据
Hu Qian,Xinwei Wang,Liping Yang et al.
Hu Qian et al.
The precise impact of febrile neutropenia (FN) during chemomobilization on the collection of CD34+ peripheral blood stem cells and post-transplant infection(s) in patients with multiple myeloma (MM) and lymphoma undergoing autologous stem c...
Transcriptomics-based multi-omics approach for optimizing risk stratification in acute myeloid leukemia [0.03%]
基于转录组的多组学方法在急性髓系白血病风险分层中的优化应用
Yang Yang,Lun Yan,Jianjun Fang et al.
Yang Yang et al.
Acute myeloid leukemia (AML) is a subtype of hematopoietic neoplasm affecting myeloid cells in blood and bone marrow. Molecular subtyping of AML provides in-depth insights into disease pathogenesis, facilitating clinical diagnostics and the...
ABCB6 promotes multidrug resistance in leukemia by mediating drug efflux [0.03%]
ABCB6通过介导药物外排促进白血病的多药耐药性
Zhongxiang Jiao,Huasong Yu,Yiran Zhang et al.
Zhongxiang Jiao et al.
Multidrug resistance (MDR) remains a major obstacle in the clinical treatment of leukemia, severely limiting therapeutic efficacy and leading to poor patient outcomes. Drug efflux mediated by ATP-binding cassette (ABC) transporters represen...
Enforced BATF expression via clinically approved LNPs enhances adoptive T-cell therapies [0.03%]
通过临床批准的脂质纳米颗粒强制表达BATF可增强过继性T细胞治疗的效果
Hanchi Ge,Keyu Wang,Lianting Chen et al.
Hanchi Ge et al.
Chimeric antigen receptor (CAR) T-cell therapy is highly effective in hematologic malignancies, yet its durability is limited by insufficient expansion, persistence, and T-cell exhaustion. Basic leucine zipper ATF-like transcription factor ...
The role of MXRA7 in bone marrow senescence involves macrophage polarization and microenvironment remodeling [0.03%]
MXRA7通过调节巨噬细胞极化和微环境重构参与骨髓衰老的作用机制研究
Yuzhen Qin,Ziyan Zhao,Yihan Chen et al.
Yuzhen Qin et al.
Marrow senescence contributes to overall organismal aging and involves functional alterations in both the mesenchymal and hematopoietic compartments of bone marrow. Although matrix remodeling-associated 7 (MXRA7) has been demonstrated to mo...
A novel UBASH3B::PVT1 fusion in B-cell acute lymphoblastic leukemia with PAX5-PTD: a case report and literature review [0.03%]
UBASH3B::PVT1新融合在PAX5-PTD型B细胞急性淋巴细胞白血病中的意义：病例报告及文献复习
Xinmei Zhuang,Yun Wang,Qian Yang et al.
Xinmei Zhuang et al.
Sequential in vivo CRISPR screens identify the clonal dominance of Nf1 loss in long-term hematopoiesis [0.03%]
基于CRISPR的体内逐帧筛选发现Nf1基因丢失在长期造血中的克隆优势
Shiru Yuan,Qian Wu,Tong Yin et al.
Shiru Yuan et al.
Systematically interrogating the genetic regulators of long-term hematopoietic stem cell (HSC) function and their roles in malignant transformation in vivo remains a central challenge. We developed and validated a sequential in vivo CRISPR ...
Apoptosis-related gene model predicts the prognosis in patients with acute myeloid leukemia [0.03%]
与凋亡相关的基因模型预测急性髓系白血病患者的预后
Xiang Pei,Wenbing Liu,Yishuang Li et al.
Xiang Pei et al.
Acute myeloid leukemia (AML) is a hematological malignancy with a high mortality rate and heterogeneous prognosis. Traditional risk stratification is based on the genetic classification in the 2022 guidelines of the European Leukemia Net. H...
Breakthroughs and challenges of CAR-T cell therapy in treating hematologic malignancies of the central nervous system [0.03%]
CAR-T细胞治疗中枢神经系统血液系统恶性肿瘤的突破与挑战
Xiaoning Li,Haili Da,Jie Zhao et al.
Xiaoning Li et al.
Chimeric antigen receptor T (CAR-T) cell therapy has transformed hematologic cancer treatment; however, its application in patients with central nervous system (CNS) involvement remains challenging because of exclusion from key trials. Rece...
Allogeneic hematopoietic stem cell transplantation combined with dasatinib successfully treated adult acute lymphoblastic leukemia with e1a3 BCR-ABL1 fusion gene positivity: a case report and literature review [0.03%]
异基因造血干细胞移植联合达沙替尼成功治疗成人E1A3BCR-ABL1融合基因阳性急性淋巴细胞白血病1例及相关文献复习
Wenhui Liu,Tao Wu,Yang Liu et al.
Wenhui Liu et al.