Poriae cutis triterpenes ameliorate metabolic-associated steatotic liver disease by inhibiting PXR/NLRP3 pathways [0.03%]
猪苓甲素通过抑制PXR/NLRP3信号通路改善代谢性肝病
Tingting Lyu,Wenjing Ma,Chen Zhang et al.
Tingting Lyu et al.
Neurobiology of cancer: Unraveling the roles of the nervous system in tumor initiation, progression, and therapeutic [0.03%]
癌症神经生物学：探讨神经系统在肿瘤发生、发展及治疗中的作用
Liang Zhou,Xiang Luo,Tianjie Bao et al.
Liang Zhou et al.
Accumulating evidence highlights a complex interplay between the nervous system and cancer; the nervous system has a significant influence on tumor progression. This review explores the burgeoning field of neuro-oncology, focusing on the ne...
Amyloid beta aggregation seeding activity as a new biomarker for Alzheimer's disease [0.03%]
淀粉样蛋白β聚集种子活性可作为阿尔茨海默病的新生物标志物
Yang Song,Siqi Xie,Tingting Li et al.
Yang Song et al.
Background: Blood-based biomarkers would greatly facilitate the clinical diagnosis of Alzheimer's disease (AD) as minimally invasive measurements. While several blood biomarkers for AD have emerged, the potential of plasm...
Multiomics contributes to the discovery of common factors in alcohol- and hepatitis B virus-related liver fibrosis [0.03%]
多组学研究揭示酒精和乙肝病毒所致肝纤维化的共同机制
Yutong Dong,Qingtian Guan,Baisong Zheng et al.
Yutong Dong et al.
Background: Liver fibrosis due to alcohol consumption or chronic hepatitis B virus (HBV)-related liver disease is a major challenge for global health. Despite the different mechanisms of primary liver injury and disease-s...
Glioma microenvironment: Cellular crosstalk, immunosuppression, and novel therapeutic perspectives [0.03%]
胶质瘤微环境：细胞串扰，免疫抑制和新型治疗策略
Yanjia Hu,Jian Liang,Jianguo Xu et al.
Yanjia Hu et al.
Glioma, the most aggressive primary brain malignancy, arises from glial cells within the central nervous system. Despite aggressive treatment, the prognosis remains poor, with all patients expected to experience recurrence. An important com...
Mechanism of mitochondrial biogenesis regulated by PGC-1α/NR1D1 to increase the vulnerability of myocardial ischemia/reperfusion injury in diabetes [0.03%]
糖尿病心肌缺血再灌注损伤易感性的PGC-1α/NR1D1介导的线粒体生物生成机制研究
Jiahui Cui,Shan Gao,Lu Li et al.
Jiahui Cui et al.
Background: Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates the expression of clock gene nuclear receptor subfamily 1 group D member 1 (NR1D1) and is closely related to diabetes mellitus ...
CD26 + CD39 - CD73 + CD4 + T lymphocytes decrease after HIV-1 infection but show an intrinsic association with low viral replication and high CD4 + T-cell count [0.03%]
HIV-1感染后CD26+CD39-CD73+CD4+T淋巴细胞减少，但与低病毒复制和高CD4+T细胞计数存在内在联系
Xin Zhang,Junyan Jin,Qianqian Xu et al.
Xin Zhang et al.
Lanlin Shen,Jinhu Ma,Xiao Wei et al.
Lanlin Shen et al.
The development of organoid technology has led to notable advances in regenerative medicine, disease modeling, and drug screening. However, given the pivotal role of vascular systems in growth maintenance and nutrient delivery, the lack of ...
Hang Qi,Taisheng Li
Hang Qi