XBP1-mediated mitochondrial damage activates the mtDNA/STING/NLRP3 pathway to delay diabetic wound healing [0.03%]
XBP1介导的线粒体损伤通过mtDNA/STING/NLRP3通路延迟糖尿病创面修复
Min Yi,Wei Yan,Liying Tu et al.
Min Yi et al.
Background: Diabetic wounds (DBW) are characterized by high levels of reactive oxygen species (ROS) and pro-inflammatory factors; reducing inflammation is therefore a key strategy in the treatment of chronic diabetic woun...
Effect of cytoreductive chemotherapy on the incidence of differentiation syndrome in patients with newly diagnosed acute promyelocytic leukemia [0.03%]
根除性化疗对新诊断的急性早幼粒细胞白血病患者分化综合征发病率的影响
Huijuan Lou,Hailang Xu,Huanxin Zhang et al.
Huijuan Lou et al.
Comparable survival outcomes for secondary and de novo acute myeloid leukemia after haploidentical hematopoietic stem cell transplantation [0.03%]
单倍型造血干细胞移植后继发和原发急性髓系白血病的生存结局相当
Kehan Zhang,Yingjun Chang,Yuqian Sun et al.
Kehan Zhang et al.
Amivantamab plus chemotherapy vs. chemotherapy as first-line treatment in Chinese mainland patients with EGFR exon 20 insertion non-small cell lung cancer: Subgroup analysis of the randomized PAPILLON trial [0.03%]
莫莫托马布联合化疗对比单纯化疗一线治疗中国大陆EGFR 20号外显子插入突变非小细胞肺癌患者的疗效：PAPILLON研究亚组分析
Kejing Tang,Fengying Wu,Fang Yang et al.
Kejing Tang et al.
Background: First-line amivantamab plus carboplatin-pemetrexed demonstrated efficacy and an acceptable safety profile in the PAPILLON trial (NCT04538664) in patients with advanced non-small cell lung cancer with epidermal...
A novel mucosal lymphatic vessel classification correlating with histopathology of early esophageal squamous cell carcinoma: A proposed system from China [0.03%]
中国提出的食管鳞状细胞早期癌粘膜淋巴管分类与组织病理学相关的新系统
Yuhang Zhang,Tingfa Peng,Liansong Ye et al.
Yuhang Zhang et al.
Targeting copper metabolic homeostasis to enable cuproptosis-based cancer therapy [0.03%]
靶向铜代谢稳态以实现基于杯鲁普西斯的癌症治疗
Chenliang Zhang,Xinyu Dai,Liping Li
Chenliang Zhang
Cuproptosis, a recently defined form of programmed cell death, provides a new vantage point for cancer therapy. In tumor cells, copper (Cu) metabolic homeostasis is essential to satisfy heightened copper demands while preventing its toxicit...
Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility [0.03%]
色氨酸代谢：调节女性生殖健康（不仅仅关于生育）的隐藏调控因素
Qingyang Wu,Fengwu Zeng,Jie Qiao et al.
Qingyang Wu et al.
Female reproductive health encompasses fertility, safe pregnancy and childbirth, and is vital throughout the entire life of women. Tryptophan, an essential amino acid in humans, is involved in protein synthesis and the generation of bioacti...
Connexin 43 promotes stemness of leukemia cells and chemoresistance in T-cell acute lymphoblastic leukemia via the RAC1/AKT/GSK3β axis [0.03%]
连接素43通过RAC1/AKT/GSK3β轴促进T细胞急性淋巴细胞白血病干细胞特性及耐药性
Rui Ji,Huihui An,Lichao Liu et al.
Rui Ji et al.
Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that remains a clinical challenge because of drug resistance and relapse, necessitating deeper insights into the mechanism ...
Single-cell sequencing identifies characteristics of disease and bone marrow in concurrent multiple myeloma and myelodysplastic syndrome [0.03%]
单细胞测序揭示多发性骨髓瘤合并骨髓增生异常综合征的疾病及骨髓特征
Jingjing Wang,Yuping Zhong,Xiuli Sun et al.
Jingjing Wang et al.
Preoperative iron status and its association with adverse outcomes in pediatric congenital heart disease [0.03%]
先天性心脏病患儿术前铁状态及其与不良结局的关系分析
Huayan Shen,Qiyu He,Sirui Zhou et al.
Huayan Shen et al.
Background: Iron imbalance, including iron deficiency and overload, is associated with increased cardiovascular morbidity and mortality. However, the iron status and its association with postoperative adverse outcomes in ...