Yang Hu,Xuben Wang,Hongdi Ma et al.
Yang Hu et al.
Cancer immunotherapy has made significant strides, yet current approaches mainly targeting the adaptive immune system yield limited clinical success. Innate immunity, as the first line of defense, directly eliminates tumor cells and activat...
Cardiovascular risk of isolated systolic hypertension in young-to-middle-aged adults in China: A prospective cohort study [0.03%]
中国年轻及中年人群单纯收缩期高血压的心血管病风险：一项前瞻性队列研究
Hao Wang,Ying Zhang,Jiansong Yuan et al.
Hao Wang et al.
Background: The clinical significance of isolated systolic hypertension (ISH) among young-to-middle-aged adults remains controversial. This study aimed to investigate the association between ISH and cardiovascular disease...
Effect of plasminogen activator inhibitor-1 transcriptionally upregulated by C-terminal truncated hepatitis B virus X on the development of hepatocellular carcinoma [0.03%]
HBV X蛋白C端缺失通过转录上调PAI-1促进肝癌发生发展的作用及机制研究
Jiayi Zhao,Yifan Chen,Rui Pu et al.
Jiayi Zhao et al.
Background: C-terminal carboxy-truncated hepatitis B virus X (Ct-HBx) exerts its hepatocarcinogenic effects, at least in part, through the upregulation of plasminogen activator inhibitor-1 (PAI-1). This study aimed to exp...
Immunotherapy for gynecological tumors: From mechanism to clinical practice [0.03%]
妇科肿瘤的免疫治疗：从机制到临床实践
Jian Liu,Min Wu,Hui Wang
Jian Liu
Gynecological tumors are a group of prevalent and highly lethal malignancies affecting the female reproductive system. The immunosuppressive tumor microenvironment, characterized by immune cell dysfunction and inhibitory cytokine dysregulat...
Cardiac immunity and heart repair: Mechanism, challenge, and future direction [0.03%]
心脏免疫与心肌修复：机制、挑战与未来方向
Yuan Liu,Qiyu Ren,Hao Wang et al.
Yuan Liu et al.
Immune signaling has emerged as a central regulator of cardiac biology, extending far beyond its traditionally recognized roles in pathology. From embryogenesis to adulthood, immune cells orchestrate key processes, including coronary vascul...
Pulmonary arterial hypertension from a translational perspective: Bridging pathophysiology and treatment [0.03%]
从转化医学的角度看肺动脉高压：病理生理学与治疗之间的桥梁
Taeil Yang,Wook-Jin Chung
Taeil Yang
Pulmonary arterial hypertension (PAH) is a rare, progressive disorder defined by elevated pulmonary arterial pressure and vascular resistance, ultimately leading to right ventricular failure and premature death. Once considered a disease of...
Intelligent three-dimensional imaging in pathology: Applications and developments [0.03%]
病理学中的智能三维影像技术：应用与进展
Wentian Si,Fang Zhao,Dong Kuang et al.
Wentian Si et al.
Conventional two-dimensional (2D) pathology relies on a limited number of tissue sections and therefore provides information from isolated planes, which can introduce sampling bias and lead to the loss of axial details, making it difficult ...
Application of hydrogel technologies in the treatment of musculoskeletal disorders [0.03%]
水凝胶技术在骨科疾病治疗中的应用研究进展
Jiahao Li,Xin Su,Yuan Dong et al.
Jiahao Li et al.
Musculoskeletal disorders (MSDs) represent a diverse group of conditions affecting bones, cartilage, intervertebral discs, tendons, muscles, and related structures, and continue to be a leading cause of global disability. Despite advancemen...