Burden and risk factors of stroke worldwide and in China: An analysis from the Global Burden of Disease Study 2021 [0.03%]
2021年全球疾病负担研究中的全球及中国卒中疾病负担和危险因素分析
Zhengbao Zhu,Mengyao Shi,Quan Yu et al.
Zhengbao Zhu et al.
Background: Stroke is the leading cause of death and long-term disability worldwide, including China. This study aimed to provide timely updates on stroke burden and stroke-related risk factors to help improve population-...
ROS and Drp1-mediated mitochondrial fission contributes to the hyposalivation caused by Sjögren's disease [0.03%]
ROS和Drp1介导的线粒体分裂参与Sjögren病低分泌的机制研究
Yu Zhang,Zhihao Du,Shan Zhang et al.
Yu Zhang et al.
Background: Sjögren's disease (SjD) is an autoimmune disorder characterized by sicca syndrome with undetermined roles of reactive oxygen species (ROS) and mitochondrial dynamics in the damaged glands. This study aimed to...
Prostaglandins supplementation enhances the efficacy of standard care on renal outcomes in patients with diabetic kidney disease [0.03%]
前列腺素补充可增强标准治疗在糖尿病肾脏病患者中的疗效
Xia Gu,Danyang Zhang,Shimin Jiang et al.
Xia Gu et al.
Combination of gemox, lenvatinib, and PD-1 blockade vs. gemox monotherapy as first-line treatment for intrahepatic cholangiocarcinoma with metastases [0.03%]
与单纯吉西他滨联合奥沙利铂(GEMOX)治疗相比，吉西他滨联合奥沙利铂、仑伐替尼和PD-1抑制剂联合治疗转移性肝内胆管癌患者的疗效：一项前瞻性随机对照研究
Wenjing Zhang,Wei Liang,Hongji You et al.
Wenjing Zhang et al.
CircRERE promotes myocardial ischemia/reperfusion injury by increasing UHRF1 mRNA decay through targeting PUM2 to reduce Drp1 promoter methylation [0.03%]
Circular RNA RERE通过靶向PUM2促进UHRF1 mRNA降解，从而减少Drp1启动子甲基化并参与心肌缺血再灌注损伤
Shihui Fu,Yan Nie,Ping Ping et al.
Shihui Fu et al.
Background: Myocardial ischemia/reperfusion (I/R) injury contributes significantly to cardiac dysfunction following myocardial infarction, mainly due to excessive oxidative stress and mitochondrial injury. Despite advance...
Global, regional, and national temporal trend in burden of chronic respiratory diseases from 1990 to 2021: Findings from the Global Burden of Disease Study 2021 [0.03%]
1990年至2021年慢性呼吸系统疾病负担的全球、区域和国家时间趋势：来自全球疾病负担研究2021年的结果
Zifeng Ma,Bing Li,Yuheng Qian et al.
Zifeng Ma et al.
Background: Chronic respiratory diseases (CRDs), including chronic obstructive pulmonary disease (COPD), asthma, pneumoconiosis, interstitial lung disease (ILD), and pulmonary sarcoidosis, continue to pose a significant g...
Dongning Su,Yuanchu Zheng,Tao Feng
Dongning Su
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, highlighting the urgent need for improved diagnostic and therapeutic strategies. Biomarkers from cerebrospinal fluid (CSF), blood, and peripheral tissu...
Analysis and prediction of disease burden of stroke and its subtypes in China from 1990 to 2040 [0.03%]
中国卒中及其亚型疾病负担的分析和预测（1990～2040年）
Jing Wang,Chunlong Xiao,Zhao Cheng et al.
Jing Wang et al.
Background: In China, stroke burden remains severe as it is a major cause of mortality and disability. Detailed analyses across different subtypes will help optimize intervention strategies, enhance resource allocation ef...
SOTA: A statistical tool for quantifying the superiority onset time of PD-1/PD-L1 inhibitor response based on Kaplan-Meier graphics and its application in a meta-analysis of NSCLC randomized controlled trials [0.03%]
基于Kaplan-Meier图形的PD-1/PD-L1抑制剂反应优势起效时间的统计量化工具SOTA及其在NSCLC随机对照试验meta分析中的应用研究
Qihan Fan,Xuan Wang,Yanru Wang et al.
Qihan Fan et al.
Background: PD-1/PD-L1 inhibitors exert a unique delayed effect in clinical practice, although the exact duration of this delay remains inconclusive. To address this, we developed an algorithm-SOTA (Superiority Onset-Time...