Molecular characterization of FGFR fusion in a large real-world population and clinical utility of bidirectional fusion [0.03%]
FGFR融合的大规模真实世界人群分子特征及双向融合的临床应用价值
Xinyi Zhang,Jing Zhao,Ling Ma et al.
Xinyi Zhang et al.
SAMSN1 causes sepsis immunosuppression by inducing macrophages to express coinhibitory molecules that cause T-cell exhaustion via KEAP1-NRF2 signaling [0.03%]
SAMSN1通过诱导巨噬细胞表达共抑制分子并激活KEAP1-NRF2信号导致T细胞衰竭从而引起脓毒症免疫抑制
Yao Li,Tingting Li,Fei Xiao et al.
Yao Li et al.
Background: Immunosuppression is closely related to the pathogenesis of sepsis, but the underlying mechanisms have not yet been fully elucidated. In this study, we aimed to examine the role of the Sterile Alpha Motif, Src...
Intestinal metabolites in colitis-associated carcinogenesis: Building a bridge between host and microbiome [0.03%]
肠道代谢物在结肠炎相关癌症发生中的作用：连接宿主和微生物群的桥梁
Yating Fan,Yang Li,Xiangshuai Gu et al.
Yating Fan et al.
Microbial-derived metabolites are important mediators of host-microbial interactions. In recent years, the role of intestinal microbial metabolites in colorectal cancer has attracted considerable attention. These metabolites, which can be d...
Use of cellular free nucleic acids for diagnosis and treatment of inflammatory bowel disease [0.03%]
细胞游离核酸在炎症性肠病诊断和治疗中的应用
Jing Ai,Xiaoyan Duan,Rui Wang et al.
Jing Ai et al.
LGR5 interacts with HSP90AB1 to mediate enzalutamide resistance by activating the WNT/β-catenin/AR axis in prostate cancer [0.03%]
LGR5与HSP90AB1相互作用，通过激活WNT/β-catenin/AR轴介导前列腺癌耐药性
Ze Gao,Zhi Xiong,Yiran Tao et al.
Ze Gao et al.
Background: Enzalutamide, a second-generation androgen receptor (AR) pathway inhibitor, is widely used in the treatment of castration-resistant prostate cancer. However, after a period of enzalutamide treatment, patients ...
Global burden of metabolic-associated fatty liver disease: A systematic analysis of Global Burden of Disease Study 2021 [0.03%]
代谢相关脂肪性肝病的全球疾病负担：2021年全球疾病负担研究系统分析
Yichen Wang,Xiaoquan Huang,Sitao Ye et al.
Yichen Wang et al.
Background: Metabolic-associated fatty liver disease (MAFLD) is a common liver disease and may become the leading cause of severe liver disease in the future. The Global Burden of Disease (GBD) study assesses MAFLD's impa...
Severe COVID-19 and inactivated vaccine in diabetic patients with SARS-CoV-2 infection [0.03%]
糖尿病患者严重新冠肺炎与灭活疫苗的作用关系研究
Yaling Yang,Feng Wei,Duoduo Qu et al.
Yaling Yang et al.
Collagen-based micro/nanogel delivery systems: Manufacturing, release mechanisms, and biomedical applications [0.03%]
基于胶原蛋白的微/纳米凝胶递送系统：制备、释放机制及生物医学应用
Bowei Du,Shuhan Feng,Jiajun Wang et al.
Bowei Du et al.
Collagen-based materials, renowned for their biocompatibility and minimal immunogenicity, serve as exemplary substrates in a myriad of biomedical applications. Collagen-based micro/nanogels, in particular, are valued for their increased sur...
Lasse Jensen,Ziheng Guo,Xiaoting Sun et al.
Lasse Jensen et al.
The vasculature plays a critical role in homeostasis and health as well as in the development and progression of a wide range of diseases, including cancer, cardiovascular diseases, metabolic diseases (and their complications), chronic infl...
Decoding the genetic and environmental forces in propelling the surge of early-onset colorectal cancer [0.03%]
破解遗传和环境因素在推动早发型结直肠癌发病率上升中的作用
Jianhui Zhao,Haosen Ji,Kangning Li et al.
Jianhui Zhao et al.
Early-onset colorectal cancer (EOCRC) shows a different epidemiological trend compared to later-onset colorectal cancer, with its incidence rising in most regions and countries worldwide. However, the reasons behind this trend remain unclea...