Stanniocalcin 1 promotes gastric cancer progression by activating the PI3K/AKT pathway and inducing M2 macrophage polarization via the JAK2/STAT3/lL-10 axis [0.03%]
胃癌转移中硬骨素通过PI3K/AKT信号轴和JAK2/STAT3/lL-10轴促进M2型巨噬细胞极化的作用机制研究
Ju Huang,Xi Wu,Yunlu Feng et al.
Ju Huang et al.
Background: Stanniocalcin 1 (STC1) is an immune checkpoint in macrophages that promotes tumor immune evasion and resistance to immunotherapy. This study aims to elucidate the functional role and underlying regulatory mech...
Deep learning-based computational pathology: Technologies, clinical applications, and future directions [0.03%]
基于深度学习的计算病理学：技术、临床应用及未来方向
Yunqiu Gao,Teng Ma,Lisha Li et al.
Yunqiu Gao et al.
The adoption of whole-slide imaging is establishing a new paradigm in digital pathology. However, the translation of artificial intelligence (AI) from research to clinical practice faces significant hurdles, largely due to a misalignment be...
ICBcDrug: An online resource and tool for screening and predicting immunotherapy combination drugs [0.03%]
ICBcDrug：一种用于筛查和预测免疫治疗联合用药的在线资源及工具
Yu Lin,Wen Sun,Yun Xia et al.
Yu Lin et al.
Background: Combining small molecules with immune checkpoint blockade (ICB) therapy is an effective strategy for improving therapeutic efficacy. However, the systematic identification of small molecules that effectively p...
Akkermansia muciniphila enhances washed microbiota transplantation in the treatment of epilepsy [0.03%]
Akkermansia muciniphila增强洗涤菌群移植在治疗癫痫中的作用
Qianqian Li,Ruiqiao He,Xianglu Wang et al.
Qianqian Li et al.
Background: Refractory epilepsy remains a global clinical challenge. This first-in-human cohort study aimed to evaluate the efficacy and safety of washed microbiota transplantation (WMT) in the treatment of epilepsy. ...
Construction and evaluation of a new comprehensive all-age diagnostic tool for atopic dermatitis [0.03%]
一种新的全面的全年龄段诊断工具用于特应性皮炎的构建和评估
Jiahui Zhao,Jiarui Sun,Mingxuan Gao et al.
Jiahui Zhao et al.
microRNAs and long noncoding RNAs in heart failure: Biogenesis, subcellular functions, and clinical applications [0.03%]
微小核糖核酸和长非编码核糖核酸在心力衰竭中的作用：生物生成、亚细胞功能及其临床应用
Yuyan Tang,Rong Xie,Xiang Cheng et al.
Yuyan Tang et al.
Cardiovascular diseases remain the leading causes of mortality and disability, with heart failure being the end stage of various cardiovascular diseases. The well-established biological pathogenesis of heart failure includes cardiomyocyte h...
Efficacy and safety of intraventricular pemetrexed via Ommaya reservoir in the treatment of leptomeningeal metastasis from EGFR-mutant lung adenocarcinoma who progresses on third-generation TKIs: A single-arm clinical trial [0.03%]
Ommaya池灌注培美曲塞治疗三代EGFR-TKI耐药的EGFR突变型肺腺癌脑膜转移疗效及安全性单臂临床试验
Jieqi Chen,Anfeng Jiang,Yu Zeng et al.
Jieqi Chen et al.
Gallic acid attenuates the malignant phenotype of prostate cancer cells by antagonizing NF-κB/KLF7/L1CAM expression [0.03%]
没食子酸通过拮抗NF-κB/KLF7/L1CAM表达抑制前列腺癌细胞恶性表型
Jie Liu,Shibo Xu,Yuxin Tong et al.
Jie Liu et al.
Background: Prostate cancer (PCa) is a common malignancy of the urinary tract. Hormone therapy is the primary clinical option for the treatment of PCa; however, some PCa patients succumb to the disease due to malignant pr...
Predicting disease relapse in plaque psoriasis patients treated with secukinumab: A multicenter retrospective cohort study [0.03%]
一项关于司库奇尤单抗治疗的银屑病患者疾病复发预测的多中心回顾性队列研究
Wen Chen,Zhihui Yang,Xiaowen Wang et al.
Wen Chen et al.