Reimagining dementia screening: A stakeholder-informed perspective on artificial intelligence, digital biomarkers, and real-world implementation [0.03%]
重新构想痴呆症筛查：利益相关者视角下的人工智能、数字生物标志物和现实世界实施
Kevin Mekulu,Faisal Aqlan,Hui Yang
Kevin Mekulu
The approval of disease-modifying treatments for Alzheimer's disease demands a rethinking of cognitive screening. Drawing on over 180 stakeholder interviews from the NSF National I-Corps program, this perspective highlights barriers in curr...
Combined 64-channel EEG and PET evaluation of lecanemab efficacy: Two case reports [0.03%]
兰卡奈单抗疗效的联合评估（64通道脑电图和正电子发射断层扫描）：两例报告
Xichun Wang,Yumei Liu,Shuhan Fan et al.
Xichun Wang et al.
Lecanemab, an anti-amyloid-β (Aβ) monoclonal antibody, has shown potential in slowing Alzheimer's disease (AD) progression. We report divergent responses in two AD patients with similar backgrounds following lecanemab treatment. Subject 1...
Rural-urban differences in modifiable dementia risk factors among U.S. populations aged 45 years or older [0.03%]
美国45岁及以上人群可改变的痴呆症风险因素的城乡差异
Zhigang Xie,Jiamin Hu,Sericea Stallings-Smith et al.
Zhigang Xie et al.
Background: Alzheimer's disease and related dementias (ADRD) have become a significant public health concern, and the burden is disproportionately concentrated in rural areas. ...
Risk factors and gender disparity of cognitive impairment among cancer and neurological diseases regarding rural West Texas [0.03%]
关于德克萨斯州西部农村地区癌症和神经疾病患者的认知障碍风险因素及性别差异研究
Hafiz Khan,Lamourdia Dayamba,Aamrin Rafiq
Hafiz Khan
Background: The prevalence of Alzheimer's disease or dementia is rising among the elderly population in the United States and globally. Sociodemographic, cancer, and neurological disorders are associated with cognitive im...
Comparative analysis of PET and multiparametric MRI biomarkers in Alzheimer's disease continuum cohort [0.03%]
阿尔茨海默病谱系队列中PET和多模态MRI生物标志物的比较分析
Chileka Chiyanika,Nga Yan Chan,Wanting Liu et al.
Chileka Chiyanika et al.
Background: Non-invasive biomarkers are key to early Alzheimer's disease (AD) detection. Multiparametric MRI and advanced imaging offer promising, accessible tools for identifying AD-related changes, supporting timely dia...
Hyperkinesia and early-onset dementia in a female with co-occurring PSEN1 and HTT mutations: A case report [0.03%]
携带PSEN1和HTT突变的女性出现肌张力障碍和早发性痴呆一例报告
Sean Lee,Firas Kaddouh
Sean Lee
A middle-aged female with family history of early-onset dementia presented with progressive amnesia, behavioral dysregulation, and myoclonus. Workup revealed pathogenic PSEN1 variant and intermediate HTT allele (30 CAG repeats). This case i...
Social interaction mitigates cognitive impairments and tau pathology in socially isolated aged mice [0.03%]
社交互动可减轻年老小鼠的社会隔离引起的认知障碍和Tau蛋白病病理变化
Jiayu Zeng,Zhenzhen Bao,Wanbing Huang et al.
Jiayu Zeng et al.
Background: Social isolation significantly heightens the risk of dementia among the elderly. Maintaining social engagement has been proposed as a potential strategy to attenuate age-related cognitive decline. ...
Red-flagging multimorbidity clusters for Alzheimer's disease risk using explainable machine learning: Evidence from a national emergency department sample [0.03%]
基于可解释机器学习的阿尔茨海默病风险红旗多发病簇证据：来自国家急诊科样本的证据
Tursun Alkam,Ebrahim Tarshizi,Andrew H Van Benschoten
Tursun Alkam
Background: Emergency-department (ED) visits capture diagnostic data that could flag patients at heightened risk for Alzheimer's disease (AD) long before cognitive symptoms are formally recognized. ...
Effects of sleep deprivation on cognition and synaptic associated proteins in rodents: A systematic review and meta-analysis [0.03%]
睡眠剥夺对啮齿动物认知和突触相关蛋白的影响：系统评价和meta分析
Hongqi Wang,Xin Mao,Siyu Liu et al.
Hongqi Wang et al.
Background: Sleep disorders are a significant risk factor for cognitive decline and Alzheimer's disease (AD). However, preclinical studies investigating the effects of sleep deprivation (SD) on cognition and synaptic prot...
Geospatial and temporal disparities in Alzheimer's disease deaths in Argentina [0.03%]
阿根廷阿尔茨海默病死亡的时空差异
Arturo L Morales,Lautaro D Andrade,Rubén Bronberg et al.
Arturo L Morales et al.
Background: Alzheimer's disease (AD) and other dementias are currently among the leading causes of morbidity and mortality worldwide. Objective: ...