Apolipoprotein E4 allele, antibodies against periodontal microorganisms, and cognition in older adults [0.03%]
载脂蛋白E4等位基因、牙周微生物抗体与老年人认知的关系
Anwar T Merchant,Longgang Zhao,Eric Mishio Bawa et al.
Anwar T Merchant et al.
Background: The presence of the apolipoprotein E4 (APOE4) allele and periodontal disease are independently correlated with higher levels of amyloid-β and inflammation in the brain, worse cognition, and Alzheimer's diseas...
Persistence with antidementia therapy in Germany: A retrospective cohort study of 567,815 patients [0.03%]
德国抗痴呆治疗的持续性：一项关于567,815名患者的回顾性队列研究
Miriam Guba-Menzel,Felix S Hussenoeder,Karel Kostev
Miriam Guba-Menzel
Background: Despite the availability of these therapies, maintaining long-term adherence remains a significant challenge. Objective: Th...
Cost-benefit of dementia insurance for cognitively-unimpaired APOE ε4 homozygotes: A simulation study [0.03%]
APOEε4纯合子无认知障碍人群的痴呆保险成本效益仿真研究
Kenichiro Sato,Saki Nakashima,Yoshiki Niimi et al.
Kenichiro Sato et al.
Background: Dementia insurance, a private insurance product covering the first diagnosis of dementia of the insured, may be beneficial for asymptomatic individuals who recognize their own high genetic risk for Alzheimer's...
The preventive role of tempeh isoflavones on menopausal women's cognitive function: A multiple mechanism pathway [0.03%]
评估发酵大豆异黄酮对绝经期女性认知功能的预防作用及多种机制途径
Atik Kridawati,Lili Indrawati,Sugeng Hadisaputra et al.
Atik Kridawati et al.
Cognitive dysfunction in the elderly is not only a disease but also could be considered a preclinical condition of Alzheimer's disease (AD), one of the most common types of dementia in the elderly. Therefore, treatment such as early detecti...
Longitudinal impact of cholinesterase inhibitors on cholinergic white matter integrity in mild cognitive impairment: A diffusion MRI study [0.03%]
胆碱酯酶抑制剂对轻度认知障碍患者胆碱能白质完整性纵向影响的扩散MRI研究
Elham Ramezannezhad;Alzheimer&#x;s Disease Neuroimaging Initiative
Elham Ramezannezhad;Alzheimer&#x;s Disease Neuroimaging Initiative
Background: Early degeneration of the cholinergic nucleus basalis of Meynert contributes to cognitive decline in Alzheimer's disease (AD). Microstructural damage in downstream cholinergic tracts-the cingulum bundle (CGC),...
Feasibility of expiratory muscle strength training to address oropharyngeal dysphagia in a patient living with mixed dementia: A case report [0.03%]
针对混合型痴呆患者的口腔咽部吞咽障碍进行呼气肌力训练可行性研究：病例报告
Joanne Yee,Sara Gustafson,Raele Donetha Loy et al.
Joanne Yee et al.
Oropharyngeal dysphagia frequently occurs in persons living with Alzheimer's disease and related dementias (PLWD) and results in negative health consequences. Strength-based exercises may address swallowing biomechanical impairments. Expira...
Association of cardiovascular disease with dementia: A longitudinal analysis using National Alzheimer's Coordinating Center data [0.03%]
心血管疾病与痴呆的关系：基于全美阿尔茨海默病协调中心数据的纵向分析
Diana Summanwar,Hyena Kim,Jingkai Wei et al.
Diana Summanwar et al.
We analyzed how cardiovascular disease subtypes influence the prevalence and incidence of dementia among 30,582 individuals aged 50 and older in the National Alzheimer's Coordinating Center cohort. We calculated prevalence ratios (aPR) and ...
Digital adaptation of odor identification test: Current knowledge, gaps, and initial insights from a DAC global cohort [0.03%]
气味识别测试的数字转化：现有知识、差距及DAC全球队列的初步见解
Jaishree Singh,Sara A Moustafa,Subhanjan Mondal et al.
Jaishree Singh et al.
Background: Olfaction has enabled humans to survive and reproduce throughout their evolutionary history. Certain odors have been historically associated with danger while others, pleasure. Further, olfactory impairment is...
The mild cognitive impairment window for optimal Alzheimer's disease intervention [0.03%]
针对阿尔茨海默病最佳干预的轻度认知障碍期窗口
Kevin Mekulu,Faisal Aqlan,Hui Yang
Kevin Mekulu
The FDA approval of disease-modifying Alzheimer's disease therapies marks a major shift in treatment but exposes a critical challenge: identifying patients during the mild cognitive impairment (MCI) stage when intervention is most effective...
Probable lecanemab-associated pontine hemorrhage following cardiovascular intervention: Clinical implications for lecanemab use [0.03%]
心血管介入术后可能与仑卡奈单抗相关的脑桥出血：仑卡奈单抗使用的临床意义
Siwei Chen,Yongan Sun,Lanqiu Yao et al.
Siwei Chen et al.
We report a 76-year-old patient with mild cognitive impairment and APOE ε3/ε3 genotype who developed a rare pontine hemorrhage following treatment with lecanemab, an anti-amyloid-β monoclonal antibody for Alzheimer's disease. She was ini...