Impaired pathways of detoxification and risk of Alzheimer's disease: Differential gene expression studies via gene set expression analysis [0.03%]
凋毒途径异常与阿尔茨海默病风险增加的关系：通过基因集合表达分析进行差异表达研究
Mark E McCaulley
Mark E McCaulley
Background: Alzheimer's disease (AD) is a common dementing disease associated with aging for which no specific etiology has been found. Objective: ...
Instrument for Assessment of Neurodegenerative Aphasia in Indonesia or Instrumen Afasia Neurodegeneratif Indonesia (IRFANI): Development and pilot study [0.03%]
印度尼西亚神经退行性失语症评估量表（IRFANI）的编制及初步检测
Fasihah Irfani Fitri,Aldy Safruddin Rambe,Elmeida Effendy et al.
Fasihah Irfani Fitri et al.
Background: Primary progressive aphasia (PPA) is a neurodegenerative disorder causing progressive language impairment. Early diagnosis is crucial for treatment planning, yet no standardized assessment exists for Indonesia...
Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment [0.03%]
缺血性血管认知障碍的静息态功能连接的认知储备研究
Yi Gu,Chun Liang Hsu,Nárlon C Boa Sorte Silva et al.
Yi Gu et al.
Background: Subcortical ischemic vascular cognitive impairment (SIVCI) is characterized by white matter hyperintensities (WMH) that contribute to executive dysfunction and increased risk of Alzheimer's disease. Cognitive ...
Unraveling the impact of common medications on biomarker patterns in Alzheimer's disease and mild cognitive impairment [0.03%]
解读常用药物对阿尔茨海默病和轻度认知障碍生物标志模式的影响
Kaitlyn Paez,Claire Kopachik,Ali Yilmaz et al.
Kaitlyn Paez et al.
Background: The aging global population faces significant challenges from Alzheimer's disease (AD). Metabolomics offers a non-invasive, cost-effective diagnostic alternative. Researchers identified significant variations ...
Identification of novel serum biomarkers for Alzheimer's disease screened by phage display library of random peptides [0.03%]
随机肽噬菌体展示文库筛选阿尔茨海默病新型血清生物标志物的鉴定研究
Dandan Gao,Zhicheng Han,Xiaoyang Ai et al.
Dandan Gao et al.
Background: Identification of Alzheimer's disease (AD) needs inexpensive, noninvasive novel biomarkers. autoimmunity plays a key role in the pathogenesis of AD. ...
Estimates of current capacity for diagnosing and implementation of new treatment Alzheimer's disease in Slovenia [0.03%]
斯洛文尼亚当前诊断能力及新的阿尔茨海默病治疗方案实施情况估计
Eva Zupanic,Gašper Stegnar,Martin Rakuša et al.
Eva Zupanic et al.
Background: The limited efficacy of current symptomatic treatments for Alzheimer's disease (AD) leads many patients to forgo medical help. However, new disease-modifying treatments (DMTs), such as donanemab and lecanemab,...
Association between sensory impairment and incident dementia among middle-aged and older Chinese: Findings from the CHARLS cohort study [0.03%]
中国中老年人感觉功能损害与痴呆发病风险的关联——基于CHARLS队列的一项研究
Qifa Zhang,Chaofeng Fan
Qifa Zhang
Background: Aging is accompanied by increase in sensory impairments (SIs), including vision impairment (VI), hearing impairment (HI), and dual sensory impairment (DSI). However, prospective evidence on this association fr...
Insights into the role of extracellular-to-total body water ratio on neurocognitive decrements over time in Asians with type 2 diabetes [0.03%]
关于亚洲2型糖尿病患者细胞外液与总体液比值随时间变化对神经认知功能影响的洞见
Serena Low,Angela Moh,Huili Zheng et al.
Serena Low et al.
Background: Extracellular water-to-total body water (ECW/TBW) ratio reflects volume overload. It promotes aortic stiffness which predicts Alzheimer's disease and related dementias (ADRD) development. ...
An efficient non-invasive model for predicting cognitive impairment based on comprehensive geriatric assessment: Machine learning and SHAP analysis [0.03%]
基于综合老年评估的高效非侵入式认知障碍预测模型：机器学习与SHAP分析
Jia Zhang,Wenjie Li,Sha Wen et al.
Jia Zhang et al.
Background: With global aging, cognitive impairment, including Alzheimer's disease and related dementias, has become a critical public health challenge, driving the need for convenient screening tools to facilitate early ...
A novel PSEN2 missense variant in a Japanese woman with hereditary Alzheimer's disease [0.03%]
一名携带PSEN2错义变异的日本遗传性阿尔茨海默病患者
Kazuki Kasuga,Chinami Yuzawa,Katsuya Nakamura et al.
Kazuki Kasuga et al.
Hereditary Alzheimer's disease (hAD) and PSEN2 variants are rare, and the benefit of anti-amyloid β-directed monoclonal antibody (mAb) therapy is unknown. We encountered a 51-year-old Japanese woman with PSEN2-associated hAD. A molecular d...