Differential Effect of APOE Alleles on Brain Glucose Metabolism in Targeted Replacement Mice: An [18F]FDG-μPET Study [0.03%]
载有不同APOE基因的小鼠脑葡萄糖代谢差异:[18F]FDG-μPET研究
Marcello Venzi,Miklós Tóth,Jenny Häggkvist et al.
Marcello Venzi et al.
Background: The Apolipoprotein E (ApoE) alleles ɛ2, ɛ3, and ɛ4 are known to differentially modulate cerebral glucose metabolism and the risk for Alzheimer's disease (AD) via both amyloid-β (Aβ)-dependent and independ...
Optimal Cut-Off Value for Locus Coeruleus-to-Pons Intensity Ratio as Clinical Biomarker for Alzheimer's Disease: A Pilot Study [0.03%]
locus coeruleus-脑桥信号强度比作为阿尔茨海默病临床生物标志物的最佳临界值：一项初步研究
Milos Dordevic,Alessa Müller-Fotti,Patrick Müller et al.
Milos Dordevic et al.
Background: Studies using neuromelanin-sensitive-MRI have established the locus coeruleus (LC)-to-pons intensity ratio as a biomarker for diagnosis of Parkinson's and Alzheimer's diseases. More detailed analysis is needed...
Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer's Disease [0.03%]
遗传、转录组学、蛋白质组学和流行病学证据表明血脑屏障破坏和多微生物脑侵袭是阿尔茨海默病的决定性因素
Chris J Carter
Chris J Carter
Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey showed that AD genome-wide association study (GWAS) genes (localized in bone marrow, immune locations and microglia) relate to multiple host/pathogen...
Perfusion-Phase [18F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration [0.03%]
基于灌注阶段的[18F]THK5351 tau-PET成像作为神经退行性变的替代标记物
Matthias Brendel,Leonie Wagner,Johannes Levin et al.
Matthias Brendel et al.
We aimed to test if early, perfusion phase tau-PET imaging with [18F]THK5351 might substitute for [18F]FDG PET information on neurodegeneration, as has been previously shown for amyloid-tracers. A patient with cognitive impairment and posit...
Methylation Profiling RIN3 and MEF2C Identifies Epigenetic Marks Associated with Sporadic Early Onset Alzheimer's Disease [0.03%]
RIN3和MEF2C甲基化谱分析鉴定出与早发性阿尔茨海默病相关的表观遗传标记
Kirsty A Boden,Imelda S Barber,Naomi Clement et al.
Kirsty A Boden et al.
A number of genetic loci associate with early onset Alzheimer's disease (EOAD); however, the drivers of this disease remains enigmatic. Genome wide association and in vivo modeling have shown that loss-of-function, e.g., ABCA7, reduced leve...
Interictal Epileptiform Activity in the Foramen Ovale Electrodes of a Frontotemporal Dementia Patient [0.03%]
frontal颞顶交界区脑电癫痫样放电1例报告
András Horváth,Anna Szűcs,Gábor Barcs et al.
András Horváth et al.
Frontotemporal dementia (FTD) is a frequent cause of cognitive decline. While epilepsy is an important comorbidity of Alzheimer's disease, we lack studies on its presence in FTD. We report on an FTD patient with transient, short-term change...
Imaging Biomarkers in Alzheimer's Disease: A Practical Guide for Clinicians [0.03%]
阿尔茨海默病影像生物标志指南：临床医师实用手册
Nasim Sheikh-Bahaei,Seyed Ahmad Sajjadi,Roido Manavaki et al.
Nasim Sheikh-Bahaei et al.
Although recent developments in imaging biomarkers have revolutionized the diagnosis of Alzheimer's disease at early stages, the utility of most of these techniques in clinical setting remains unclear. The aim of this review is to provide a...
Survival Curves and Behavioral Profiles of Female 3xTg-AD Mice Surviving to 18-Months of Age as Compared to Mice with Normal Aging [0.03%]
与正常衰老小鼠相比18月龄的3xTg-AD雌性小鼠的存活曲线和行为特征
Virginia Torres-Lista,Mónica De la Fuente,Lydia Giménez-Llort
Virginia Torres-Lista
New evidence reveals a high degree of heterogeneity in Alzheimer's disease (AD) clinical and temporal patterns, supporting the existence of several subgroups of patients. Prognosticators of end-of-life dementia specific to elderly patients ...
Pravat K Mandal,Krity Kansara,Aroma Dabas
Pravat K Mandal
Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease with no cure to date. Emerging evidence indicates aberrations of the primary inhibitory neurotransmitter GABA in the frontal, parietal and temporal cortices, and hi...
Md Rashidur Rahman,Afsana Tajmim,Mohammad Ali et al.
Md Rashidur Rahman et al.
Alzheimer's disease (AD) is a complex neurological disorder with economic, social, and medical burdens which is acknowledged as leading cause of dementia marked by the accumulation and aggregation of amyloid-β peptide and phosphorylated ta...