The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques [0.03%]
Bri2和Bri3的BRICHOS结构域与Aβ42和阿尔茨海默病淀粉样斑块的相互作用不同
Lisa Dolfe,Simone Tambaro,Helene Tigro et al.
Lisa Dolfe et al.
Alzheimer's disease (AD) is the most common form of dementia and there is no successful treatment available. Evidence suggests that fibril formation of the amyloid β-peptide (Aβ) is a major underlying cause of AD, and treatment strategies...
Increased All-Cause Mortality by Antipsychotic Drugs: Updated Review and Meta-Analysis in Dementia and General Mental Health Care [0.03%]
抗精神病药物全因死亡率增加：痴呆和一般精神卫生保健的更新回顾和荟萃分析
Stephen J Ralph,Anthony J Espinet
Stephen J Ralph
It is almost ten years since the Banerjee 2009 report established that inappropriate prescribing of antipsychotics in the elderly was occurring in the UK and such patients had an 85% increased risk of adverse events and greater mortality. T...
Studies on Copper and Aβ1-16-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequence [0.03%]
铜和Aβ1-16诱导的CAG/CTG三核苷酸重复序列构象变化的研究
M Govindaraju,K S Rao Jayanth,D Jagadeesh Kumar et al.
M Govindaraju et al.
DNA conformation and stability are critical for the normal cell functions, which control many cellular processes in life, such as replication, transcription, DNA repair, etc. The accumulation of amyloid-β peptide (Aβ) and Copper (Cu) are ...
Prion Protein PRNP: A New Player in Innate Immunity? The Aβ Connection [0.03%]
朊蛋白PRNP：先天免疫中的新角色？与Aβ的联系
Richard Lathe,Jean-Luc Darlix
Richard Lathe
The prion protein PRNP has been centrally implicated in the transmissible spongiform encephalopathies (TSEs), but its normal physiological role remains obscure. We highlight emerging evidence that PRNP displays antimicrobial activity, inhib...
Validation of the English Version of the Multimodal Assessment of Capacities in Severe Dementia (MAC-SD): A Cognitive and Functional Scale for Use in Severe Dementia [0.03%]
严重痴呆多模态评估量表(MAC-SD)英文版的效度研究：一种用于重度痴呆的认知和功能评估量表
Sloane Heller,Alan Steinberg,Mark Sedler
Sloane Heller
Background: Most existing screening instruments that assess cognition and functioning in dementia suffer from floor effects, limiting their utility in severely demented patients. In 2015, the first author devised a new in...
Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels [0.03%]
阿尔茨海默病风险基因ABCA7的缺失影响白色脂肪组织的发育及瘦素水平
Surabhi Bhatia,YuHong Fu,Jen-Hsiang T Hsiao et al.
Surabhi Bhatia et al.
ATP-binding cassette A7 (ABCA7) is a genetic risk factor for late-onset Alzheimer's disease (AD). It belongs to a group of transporter genes that specializes in regulating lipid transport in the periphery as well as in the brain. ABCA7 has ...
A Possibility of Simultaneous Treatment with the Multicomponent Drug, Ninjin'yoeito, for Anorexia, Apathy, and Cognitive Dysfunction in Frail Alzheimer's Disease Patients: An Open-Label Pilot Study [0.03%]
四物汤多组分药物治疗阿尔茨海默病脆弱患者厌食、冷漠和认知功能障碍的可行性：开放标记试点研究
Makoto Ohsawa,Yukiko Tanaka,Yoshito Ehara et al.
Makoto Ohsawa et al.
A recent classification analysis of neuropsychiatric symptoms in patients with Alzheimer's disease (AD) revealed a distinct cluster with apathy and eating problems including anorexia that exhibits frailty. The apathy and frailty are risk fa...
Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy [0.03%]
中年与工作相关的压力与晚年灰质体积萎缩有关
Shireen Sindi,Ingemar Kåreholt,Gabriela Spulber et al.
Shireen Sindi et al.
Background: Work-related stress has been associated with an increased dementia risk. However, less is known about the mechanisms that underlie these associations. ...
Efficacy and Safety of the Immunization with DNA for Alzheimer's Disease in Animal Models: A Systematic Review from Literature [0.03%]
阿爾茲海默病動物模型DNA免疫的療效和安全性系統文獻綜述
Yandara Akamine Martins,Cristiane Jumko Tsuchida,Patrícia Antoniassi et al.
Yandara Akamine Martins et al.
Background: Alzheimer's disease (AD) is a neurodegenerative disease that does not have a proven cure; however, one of the most promising strategies for its treatment has been DNA vaccines. ...
Wee Ping Wong,Jan Coles,Richard Chambers et al.
Wee Ping Wong et al.
Background: The current lack of an effective cure for dementia would exacerbate its prevalence and incidence globally. Growing evidence has linked mindfulness to cognitive and psychological improvements that could be rele...