RNA-Sequencing Reveals Similarities and Differences in Gene Expression in Vulnerable Brain Tissues of Alzheimer's and Parkinson's Diseases [0.03%]
RNA序列分析揭示阿尔茨海默病与帕金森病易感脑区基因表达的相似性及差异性
James P Bennett,Paula M Keeney
James P Bennett
Background: Neuropathological changes of Alzheimer's disease (AD) and Parkinson's disease (PD) can coexist in the same sample, suggesting possible common degenerative mechanisms. ...
No Relationship of Anti-Androgens to Alzheimer's Disease or Cognitive Disorder in the MedWatch Database [0.03%]
美国FDA不良事件报告系统中抗雄激素与阿尔茨海默病或认知障碍无关联性分析
Steven Lehrer,Peter H Rheinstein,Kenneth E Rosenzweig
Steven Lehrer
Background: Two large studies suggest that risk is not increased. But other studies have found increased risk of Alzheimer's disease and impaired cognition. ...
Aripiprazole for the Treatment of Inappropriate Sexual Behavior: Case Report of an Alzheimer's Disease Patient Known as Heterosexual with Recently Shifted Sexual Orientation to Same Gender [0.03%]
阿立哌唑治疗阿尔茨海默病伴异性转同性恋不适当性行为患者的疗效观察：病例报告
Sevda Sarikaya,Basar Sarikaya
Sevda Sarikaya
Although inappropriate sexual behavior in dementia is not common, it can be extremely troublesome for healthcare professionals and caregivers as well as patients themselves. There is paucity of data in the literature for the management of t...
Ángel J Picher,Félix Hernández,Bettina Budeus et al.
Ángel J Picher et al.
Genetic factors may be involved in the onset of neurodegenerative diseases like Alzheimer's disease. In the case of the familial type, the disease is due to an inherited mutation at specific sites in three genes. Also, there are some geneti...
Cognitive Functioning Differences Between Physically Active and Sedentary Older Adults [0.03%]
身体活跃和久坐不动的老年人的认知功能差异
Ben Younan
Ben Younan
Older adults engaging in regular physical activity can help create a buffer toward cognitive decline. The main aim of this study was to assess the effects of physical activity and cognitive functioning on a sample of young-old and old-old p...
Neonatal Neurodegeneration in Alzheimer's Disease Transgenic Mouse Model [0.03%]
阿尔茨海默病转基因小鼠模型中的新生儿神经退行性疾病
Aise Rumeysa Mazi,Aysegul Sumeyye Arzuman,Busra Gurel et al.
Aise Rumeysa Mazi et al.
Alzheimer's disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the diagnosis of the d...
Long-Term Non-Invasive Treatment via Intranasal Administration of Nerve Growth Factor Protects the Human Brain in Frontotemporal Dementia associated with Corticobasal Syndrome: A Pilot Study [0.03%]
鼻内给药神经生长因子长期无创治疗可保护皮质基底综合征型额颞痴呆患者大脑：一项概念验证研究
Alberto de Bellis,Massimo de Bellis,Luigi Aloe
Alberto de Bellis
Background: Nerve growth factor (NGF) is known for playing a critical protective role on a number of brain neurons in mammals, including humans. NGF can be delivered to the CNS via nasal route and has a neuroprotective ac...
Melatonin Effects on EEG Activity During Sleep Onset in Mild-to-Moderate Alzheimer's Disease: A Pilot Study [0.03%]
褪黑素对轻中度阿尔茨海默病患者入睡期脑电活动的影响：一项概念验证试验
Manuel Alejandro Cruz-Aguilar,Ignacio Ramírez-Salado,Miguel Angel Guevara et al.
Manuel Alejandro Cruz-Aguilar et al.
There is evidence demonstrating that 5-mg of fast-release melatonin significantly reduces nocturnal sleep onset in patients with mild-to-moderate Alzheimer's disease (AD). However, the physiological mechanism that could promote sleep instal...
Noel Lorenzo Villalba,Stephane Laboulbene,Tawoufik Merzouki et al.
Noel Lorenzo Villalba et al.
A 66-year-old woman presented with slowly progressive cognitive decline. MRI showed bi-frontotemporal atrophy, but the 14.3.3 protein was not present in cerebrospinal fluid. Electroencephalogram was irrelevant. Interview with relatives led ...
Atomic Force Microscopy Analysis of EPPS-Driven Degradation and Reformation of Amyloid-β Aggregates [0.03%]
利用原子力显微镜分析EPPS驱动的淀粉样蛋白-Aggregates降解和重组过程
Wonseok Lee,Sang Won Lee,Gyudo Lee et al.
Wonseok Lee et al.
Amyloid-β (Aβ) peptides can be aggregated into β-sheet rich fibrils or plaques and deposited on the extracellular matrix of brain tissues, which is a hallmark of Alzheimer's disease. Several drug candidates have been designed to retard t...