Deletion of Alzheimer's Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels [0.03%]
阿尔茨海默病风险基因ABCA7的缺失影响白色脂肪组织的发育及瘦素水平
Surabhi Bhatia,YuHong Fu,Jen-Hsiang T Hsiao et al.
Surabhi Bhatia et al.
ATP-binding cassette A7 (ABCA7) is a genetic risk factor for late-onset Alzheimer's disease (AD). It belongs to a group of transporter genes that specializes in regulating lipid transport in the periphery as well as in the brain. ABCA7 has ...
A Possibility of Simultaneous Treatment with the Multicomponent Drug, Ninjin'yoeito, for Anorexia, Apathy, and Cognitive Dysfunction in Frail Alzheimer's Disease Patients: An Open-Label Pilot Study [0.03%]
四物汤多组分药物治疗阿尔茨海默病脆弱患者厌食、冷漠和认知功能障碍的可行性：开放标记试点研究
Makoto Ohsawa,Yukiko Tanaka,Yoshito Ehara et al.
Makoto Ohsawa et al.
A recent classification analysis of neuropsychiatric symptoms in patients with Alzheimer's disease (AD) revealed a distinct cluster with apathy and eating problems including anorexia that exhibits frailty. The apathy and frailty are risk fa...
Midlife Work-Related Stress is Associated with Late-Life Gray Matter Volume Atrophy [0.03%]
中年与工作相关的压力与晚年灰质体积萎缩有关
Shireen Sindi,Ingemar Kåreholt,Gabriela Spulber et al.
Shireen Sindi et al.
Background: Work-related stress has been associated with an increased dementia risk. However, less is known about the mechanisms that underlie these associations. ...
Efficacy and Safety of the Immunization with DNA for Alzheimer's Disease in Animal Models: A Systematic Review from Literature [0.03%]
阿爾茲海默病動物模型DNA免疫的療效和安全性系統文獻綜述
Yandara Akamine Martins,Cristiane Jumko Tsuchida,Patrícia Antoniassi et al.
Yandara Akamine Martins et al.
Background: Alzheimer's disease (AD) is a neurodegenerative disease that does not have a proven cure; however, one of the most promising strategies for its treatment has been DNA vaccines. ...
Wee Ping Wong,Jan Coles,Richard Chambers et al.
Wee Ping Wong et al.
Background: The current lack of an effective cure for dementia would exacerbate its prevalence and incidence globally. Growing evidence has linked mindfulness to cognitive and psychological improvements that could be rele...
Differential Effect of APOE Alleles on Brain Glucose Metabolism in Targeted Replacement Mice: An [18F]FDG-μPET Study [0.03%]
载有不同APOE基因的小鼠脑葡萄糖代谢差异:[18F]FDG-μPET研究
Marcello Venzi,Miklós Tóth,Jenny Häggkvist et al.
Marcello Venzi et al.
Background: The Apolipoprotein E (ApoE) alleles ɛ2, ɛ3, and ɛ4 are known to differentially modulate cerebral glucose metabolism and the risk for Alzheimer's disease (AD) via both amyloid-β (Aβ)-dependent and independ...
Optimal Cut-Off Value for Locus Coeruleus-to-Pons Intensity Ratio as Clinical Biomarker for Alzheimer's Disease: A Pilot Study [0.03%]
locus coeruleus-脑桥信号强度比作为阿尔茨海默病临床生物标志物的最佳临界值：一项初步研究
Milos Dordevic,Alessa Müller-Fotti,Patrick Müller et al.
Milos Dordevic et al.
Background: Studies using neuromelanin-sensitive-MRI have established the locus coeruleus (LC)-to-pons intensity ratio as a biomarker for diagnosis of Parkinson's and Alzheimer's diseases. More detailed analysis is needed...
Genetic, Transcriptome, Proteomic, and Epidemiological Evidence for Blood-Brain Barrier Disruption and Polymicrobial Brain Invasion as Determinant Factors in Alzheimer's Disease [0.03%]
遗传、转录组学、蛋白质组学和流行病学证据表明血脑屏障破坏和多微生物脑侵袭是阿尔茨海默病的决定性因素
Chris J Carter
Chris J Carter
Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey showed that AD genome-wide association study (GWAS) genes (localized in bone marrow, immune locations and microglia) relate to multiple host/pathogen...
Perfusion-Phase [18F]THK5351 Tau-PET Imaging as a Surrogate Marker for Neurodegeneration [0.03%]
基于灌注阶段的[18F]THK5351 tau-PET成像作为神经退行性变的替代标记物
Matthias Brendel,Leonie Wagner,Johannes Levin et al.
Matthias Brendel et al.
We aimed to test if early, perfusion phase tau-PET imaging with [18F]THK5351 might substitute for [18F]FDG PET information on neurodegeneration, as has been previously shown for amyloid-tracers. A patient with cognitive impairment and posit...
Methylation Profiling RIN3 and MEF2C Identifies Epigenetic Marks Associated with Sporadic Early Onset Alzheimer's Disease [0.03%]
RIN3和MEF2C甲基化谱分析鉴定出与早发性阿尔茨海默病相关的表观遗传标记
Kirsty A Boden,Imelda S Barber,Naomi Clement et al.
Kirsty A Boden et al.
A number of genetic loci associate with early onset Alzheimer's disease (EOAD); however, the drivers of this disease remains enigmatic. Genome wide association and in vivo modeling have shown that loss-of-function, e.g., ABCA7, reduced leve...