Neonatal Neurodegeneration in Alzheimer's Disease Transgenic Mouse Model [0.03%]
阿尔茨海默病转基因小鼠模型中的新生儿神经退行性疾病
Aise Rumeysa Mazi,Aysegul Sumeyye Arzuman,Busra Gurel et al.
Aise Rumeysa Mazi et al.
Alzheimer's disease (AD) is a progressive disorder characterized by a variety of molecular pathologies causing cortical dementia with a prominent memory deficit. Formation of the pathology, which begins decades before the diagnosis of the d...
Long-Term Non-Invasive Treatment via Intranasal Administration of Nerve Growth Factor Protects the Human Brain in Frontotemporal Dementia associated with Corticobasal Syndrome: A Pilot Study [0.03%]
鼻内给药神经生长因子长期无创治疗可保护皮质基底综合征型额颞痴呆患者大脑：一项概念验证研究
Alberto de Bellis,Massimo de Bellis,Luigi Aloe
Alberto de Bellis
Background: Nerve growth factor (NGF) is known for playing a critical protective role on a number of brain neurons in mammals, including humans. NGF can be delivered to the CNS via nasal route and has a neuroprotective ac...
Melatonin Effects on EEG Activity During Sleep Onset in Mild-to-Moderate Alzheimer's Disease: A Pilot Study [0.03%]
褪黑素对轻中度阿尔茨海默病患者入睡期脑电活动的影响：一项概念验证试验
Manuel Alejandro Cruz-Aguilar,Ignacio Ramírez-Salado,Miguel Angel Guevara et al.
Manuel Alejandro Cruz-Aguilar et al.
There is evidence demonstrating that 5-mg of fast-release melatonin significantly reduces nocturnal sleep onset in patients with mild-to-moderate Alzheimer's disease (AD). However, the physiological mechanism that could promote sleep instal...
Noel Lorenzo Villalba,Stephane Laboulbene,Tawoufik Merzouki et al.
Noel Lorenzo Villalba et al.
A 66-year-old woman presented with slowly progressive cognitive decline. MRI showed bi-frontotemporal atrophy, but the 14.3.3 protein was not present in cerebrospinal fluid. Electroencephalogram was irrelevant. Interview with relatives led ...
Atomic Force Microscopy Analysis of EPPS-Driven Degradation and Reformation of Amyloid-β Aggregates [0.03%]
利用原子力显微镜分析EPPS驱动的淀粉样蛋白-Aggregates降解和重组过程
Wonseok Lee,Sang Won Lee,Gyudo Lee et al.
Wonseok Lee et al.
Amyloid-β (Aβ) peptides can be aggregated into β-sheet rich fibrils or plaques and deposited on the extracellular matrix of brain tissues, which is a hallmark of Alzheimer's disease. Several drug candidates have been designed to retard t...
The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques [0.03%]
Bri2和Bri3的BRICHOS结构域与Aβ42和阿尔茨海默病淀粉样斑块的相互作用不同
Lisa Dolfe,Simone Tambaro,Helene Tigro et al.
Lisa Dolfe et al.
Alzheimer's disease (AD) is the most common form of dementia and there is no successful treatment available. Evidence suggests that fibril formation of the amyloid β-peptide (Aβ) is a major underlying cause of AD, and treatment strategies...
Increased All-Cause Mortality by Antipsychotic Drugs: Updated Review and Meta-Analysis in Dementia and General Mental Health Care [0.03%]
抗精神病药物全因死亡率增加：痴呆和一般精神卫生保健的更新回顾和荟萃分析
Stephen J Ralph,Anthony J Espinet
Stephen J Ralph
It is almost ten years since the Banerjee 2009 report established that inappropriate prescribing of antipsychotics in the elderly was occurring in the UK and such patients had an 85% increased risk of adverse events and greater mortality. T...
Studies on Copper and Aβ1-16-Induced Conformational Changes in CAG/CTG Trinucleotide Repeats Sequence [0.03%]
铜和Aβ1-16诱导的CAG/CTG三核苷酸重复序列构象变化的研究
M Govindaraju,K S Rao Jayanth,D Jagadeesh Kumar et al.
M Govindaraju et al.
DNA conformation and stability are critical for the normal cell functions, which control many cellular processes in life, such as replication, transcription, DNA repair, etc. The accumulation of amyloid-β peptide (Aβ) and Copper (Cu) are ...
Prion Protein PRNP: A New Player in Innate Immunity? The Aβ Connection [0.03%]
朊蛋白PRNP：先天免疫中的新角色？与Aβ的联系
Richard Lathe,Jean-Luc Darlix
Richard Lathe
The prion protein PRNP has been centrally implicated in the transmissible spongiform encephalopathies (TSEs), but its normal physiological role remains obscure. We highlight emerging evidence that PRNP displays antimicrobial activity, inhib...
Validation of the English Version of the Multimodal Assessment of Capacities in Severe Dementia (MAC-SD): A Cognitive and Functional Scale for Use in Severe Dementia [0.03%]
严重痴呆多模态评估量表(MAC-SD)英文版的效度研究：一种用于重度痴呆的认知和功能评估量表
Sloane Heller,Alan Steinberg,Mark Sedler
Sloane Heller
Background: Most existing screening instruments that assess cognition and functioning in dementia suffer from floor effects, limiting their utility in severely demented patients. In 2015, the first author devised a new in...