Should the Treatment of Amyloidosis Be Personified? Molecular Mechanism of Amyloid Formation by Aβ Peptide and Its Fragments [0.03%]
淀粉样变性的治疗应人格化吗？Aβ肽及其片段的淀粉样蛋白形成分子机制
Oxana V Galzitskaya,Alexey K Surin,Anna V Glyakina et al.
Oxana V Galzitskaya et al.
Aβ40 and Aβ42 peptides are believed to be associated with Alzheimer's disease. Aggregates (plaques) of Aβ fibrils are found in the brains of humans affected with this disease. The mechanism of formation of Aβ fibrils has not been studie...
Pharmacokinetics in Rat of P8, a Peptide Drug Candidate for the Treatment of Alzheimer's Disease: Stability and Delivery to the Brain [0.03%]
治疗阿尔茨海默病的候选多肽药物P8在大鼠体内的药代动力学：稳定性及向脑内递送
Nazneen N Dewji,Marc R Azar,Leah R Hanson et al.
Nazneen N Dewji et al.
Strategies to achieve a therapy for Alzheimer's disease (AD) aimed at reducing the effects of amyloid-β (Aβ) have largely involved inhibiting or modifying the activities of the β- or γ-secretases or by the use of monoclonal antibodies (...
Pathological Increases in Neuronal Hyperactivity in Selective Cholinergic and Noradrenergic Pathways May Limit the Efficacy of Amyloid-β-Based Interventions in Mild Cognitive Impairment and Alzheimer's Disease [0.03%]
胆碱能和去甲肾上腺素能通路选择性变性的病理性神经元高活性增加可能限制了针对轻度认知障碍和阿尔茨海默病的淀粉样蛋白干预的有效性
Nunzio Pomara,Davide Bruno
Nunzio Pomara
In spite of compelling evidence linking amyloid-β (Aβ) disturbances to the pathophysiology of Alzheimer's disease (AD), Aβ-based treatments have consistently failed to produce any beneficial effects both in mild cognitive impairment (MCI...
The Assessment of Cerebrovascular Response to a Language Task from the Addenbrooke's Cognitive Examination in Cognitive Impairment: A Feasibility Functional Transcranial Doppler Ultrasonography Study [0.03%]
基于语言任务的脑血管反应性在认知障碍中的评价：一项可行性经颅多普勒超声研究
Lucy C Beishon,Ronney B Panerai,Thompson G Robinson et al.
Lucy C Beishon et al.
Background: The incidence of dementia is predicted to rise rapidly, but sensitive diagnostic tests remain elusive. Changes in cerebral blood flow velocity (CBFv) can occur at an early stage of cognitive decline, and can b...
Bodo Parady
Bodo Parady
Various fungi and bacteria can colonize in the brain and produce physical alterations seen in Alzheimer's disease (AD). Environmental and genetic factors affect the occurrence of fungal colonization, and how fungi can grow, enter the brain,...
RNA-Sequencing Reveals Similarities and Differences in Gene Expression in Vulnerable Brain Tissues of Alzheimer's and Parkinson's Diseases [0.03%]
RNA序列分析揭示阿尔茨海默病与帕金森病易感脑区基因表达的相似性及差异性
James P Bennett,Paula M Keeney
James P Bennett
Background: Neuropathological changes of Alzheimer's disease (AD) and Parkinson's disease (PD) can coexist in the same sample, suggesting possible common degenerative mechanisms. ...
No Relationship of Anti-Androgens to Alzheimer's Disease or Cognitive Disorder in the MedWatch Database [0.03%]
美国FDA不良事件报告系统中抗雄激素与阿尔茨海默病或认知障碍无关联性分析
Steven Lehrer,Peter H Rheinstein,Kenneth E Rosenzweig
Steven Lehrer
Background: Two large studies suggest that risk is not increased. But other studies have found increased risk of Alzheimer's disease and impaired cognition. ...
Aripiprazole for the Treatment of Inappropriate Sexual Behavior: Case Report of an Alzheimer's Disease Patient Known as Heterosexual with Recently Shifted Sexual Orientation to Same Gender [0.03%]
阿立哌唑治疗阿尔茨海默病伴异性转同性恋不适当性行为患者的疗效观察：病例报告
Sevda Sarikaya,Basar Sarikaya
Sevda Sarikaya
Although inappropriate sexual behavior in dementia is not common, it can be extremely troublesome for healthcare professionals and caregivers as well as patients themselves. There is paucity of data in the literature for the management of t...
Ángel J Picher,Félix Hernández,Bettina Budeus et al.
Ángel J Picher et al.
Genetic factors may be involved in the onset of neurodegenerative diseases like Alzheimer's disease. In the case of the familial type, the disease is due to an inherited mutation at specific sites in three genes. Also, there are some geneti...
Cognitive Functioning Differences Between Physically Active and Sedentary Older Adults [0.03%]
身体活跃和久坐不动的老年人的认知功能差异
Ben Younan
Ben Younan
Older adults engaging in regular physical activity can help create a buffer toward cognitive decline. The main aim of this study was to assess the effects of physical activity and cognitive functioning on a sample of young-old and old-old p...