Effects of Thioflavin T and GSK-3 Inhibition on Lifespan and Motility in a Caenorhabditis elegans Model of Tauopathy [0.03%]
新型tau蛋白病治疗药物筛选的秀丽杆线虫模型建立及其应用研究
Andrea Gamir-Morralla,Sandra Sacristán,Miguel Medina et al.
Andrea Gamir-Morralla et al.
The nematode Caenorhabditis elegans (C. elegans) is a powerful model organism to study lifespan and aging, protein aggregation, and neurodegeneration, as well as to carry out drug screenings. The C. elegans strain aex-3/T337 expresses human...
Screening for Dementia Caused by Modifiable Lifestyle Choices Using Hybrid PET/MRI [0.03%]
利用杂交PET/MRI筛查由可改变的生活方式选择引起的痴呆症
Frank S Prato,William F Pavlosky,Steven C Foster et al.
Frank S Prato et al.
Significant advances in positron emission tomography (PET) and magnetic resonance imaging (MRI) brain imaging in the early detection of dementia indicate that hybrid PET/MRI would be an effective tool to screen for dementia in the populatio...
'Amytrapper', a Novel Immobilized Sepharose API Matrix, Removes Amyloid-β from Circulation in vitro [0.03%]
一种新型固定化Sepharse API矩阵Amytrapper去除血循环中淀粉样蛋白-β肽的研究
Omkar Gandbhir,Pazhani Sundaram
Omkar Gandbhir
Alzheimer's disease (AD) is the most common cause of dementia among elderly patients afflicted by neurodegenerative diseases, caused by the accumulation of amyloid-β (Aβ). Therapeutic interventions in targeting and restricting Aβ product...
A Novel Approach of Diffusion Tensor Visualization Based Neuro Fuzzy Classification System for Early Detection of Alzheimer's Disease [0.03%]
基于神经模糊分类系统的扩散张量图像可视化的新方法以期实现阿尔茨海默病的早期诊断
Subrata Kar,D Dutta Majumder
Subrata Kar
This study examined early detection of Alzheimer's disease (AD) by diffusion tensor visualization-based methodology and neuro-fuzzy tools. Initially, we proposed a model for the early detection of AD using the measurement of apparent diffus...
Medical Plants and Nutraceuticals for Amyloid-β Fibrillation Inhibition [0.03%]
用于抑制淀粉样蛋白纤维化的药用植物和营养药品
Steffi Witter,Raiker Witter,Raivo Vilu et al.
Steffi Witter et al.
Plaque formation due to amyloid-β oligomerization and fibrillation is a key issue for its deposition in the brains of dementia and Alzheimer's disease patients. Related drugs preventing this peptide fibril accumulation bear the potential o...
Effects of Six-Month Aerobic Exercise Intervention on Sleep in Healthy Older Adults in the Brain in Motion Study: A Pilot Study [0.03%]
脑力与运动研究中六月有氧运动对健康老年人睡眠影响的试点研究
Veronica Guadagni,Cameron M Clark,Amanda Tyndall et al.
Veronica Guadagni et al.
Background: Sleep disturbances have been shown to be associated with the presence of the apolipoprotein (APOE) ɛ4 allele, the well-known genetic risk factor for late-onset sporadic Alzheimer's disease (AD). ...
Are Porphyromonas gingivalis Outer Membrane Vesicles Microbullets for Sporadic Alzheimer's Disease Manifestation? [0.03%]
牙龈卟啉单胞菌外膜囊泡是否为阿尔茨海默病的“随机表现”的微子弹？
Sim K Singhrao,Ingar Olsen
Sim K Singhrao
Our research into Alzheimer's disease (AD) focuses on the oral cavity and the brain, from which key evaluations of prospective and retrospective population-based data have shown that chronic periodontal disease existing for ten-years or ove...
Steven Lehrer
Steven Lehrer
Background: Cancer mortality and Alzheimer's disease (AD) mortality increase with age, but some studies have shown an inverse relationship of the two diseases, that is, older persons with cancer have a reduced risk of AD ...
Perspectives of General Practitioners on the Issues Surrounding the Late Diagnosis of Alzheimer's Disease [0.03%]
关于阿爾茨海默病晚期診斷問題的家庭醫生觀點
Fidelia Bature,Barbara Guinn,Dong Pang;Luton et al.
Fidelia Bature et al.
We set out to investigate the insights general practitioners (GPs) have into the early signs and symptoms of Alzheimer's disease (AD), factors that may be responsible for the late diagnosis, as well as their recommendations for early diagno...
Cognitive Improvement in Healthy Older Adults Can Parallel That of Younger Adults Following Lifestyle Modification: Support for Cognitive Reserve During Aging [0.03%]
健康老年人的认知改善可以与年轻人的生活方式改变相媲美：支持衰老过程中的认知储备理论
Thomas B Shea,Ruth Remington
Thomas B Shea
Executive function was assayed following a nutritional supplementation in healthy adults using the Trail Making Test. Comparison with published normative scores demonstrated that cohorts from 35-74 years of age displayed similar relative im...