Biopharmaceutical Monotargeting versus 'Universal Targeting' of Late-Onset Alzheimer's Disease Using Mixtures of Pleiotropic Natural Compounds [0.03%]
针对阿尔茨海默病的单靶点生物药物与使用多种天然多效化合物的通用疗法的区别研究
Howard Friel
Howard Friel
A five-year close reading of the scientific literature on late-onset Alzheimer's disease (AD) has prompted the invention of a novel therapeutic method that biomechanistically targets the targetable disease-process targets of AD with one or ...
Neuroprotective Approach of Anti-Cancer Microtubule Stabilizers Against Tauopathy Associated Dementia: Current Status of Clinical and Preclinical Findings [0.03%]
抗癌微管稳定剂治疗tauopathy相关痴呆的神经保护作用研究的现状及临床和实验发现
Pallavi Duggal,Sidharth Mehan
Pallavi Duggal
Neuronal microtubule (MT) tau protein provides cytoskeleton to neuronal cells and plays a vital role including maintenance of cell shape, intracellular transport, and cell division. Tau hyperphosphorylation mediates MT destabilization resul...
Nalini V Gorantla,Rashmi Das,Fayaj A Mulani et al.
Nalini V Gorantla et al.
Tau is a phosphoprotein with natively unfolded conformation that functions to stabilize microtubules in axons. Alzheimer's disease pathology triggers several modifications in tau, which causes it to lose its affinity towards microtubule, th...
Gemfibrozil, a Lipid-Lowering Drug, Lowers Amyloid Plaque Pathology and Enhances Memory in a Mouse Model of Alzheimer's Disease via Peroxisome Proliferator-Activated Receptor α [0.03%]
吉非罗齐通过激活过氧化物酶体增殖活化受体α降低阿尔茨海默病小鼠模型中的淀粉样蛋白斑病理并改善认知能力
Sujyoti Chandra,Kalipada Pahan
Sujyoti Chandra
Deposition of extracellular senile plaques containing amyloid-β is one of the major neuropathological characteristics of Alzheimer's disease (AD). Therefore, targeting amyloid-β dyshomeostasis is an important therapeutic strategy for trea...
BACE1 Translation: At the Crossroads Between Alzheimer's Disease Neurodegeneration and Memory Consolidation [0.03%]
β分泌酶1翻译：阿尔茨海默病神经变性与记忆巩固的交汇点
Francesc X Guix,Carmem L Sartório,Gerard Ill-Raga
Francesc X Guix
Human life unfolds not only in time and space, but also in the recollection and interweaving of memories. Therefore, individual human identity depends fully on a proper access to the autobiographical memory. Such access is hindered under pa...
Medial Temporal Lobe Disconnection and Hyperexcitability Across Alzheimer's Disease Stages [0.03%]
阿尔茨海默病各阶段颞叶内侧区断联与过度兴奋性
Lorenzo Pasquini,Farzaneh Rahmani,Somayeh Maleki-Balajoo et al.
Lorenzo Pasquini et al.
The posteromedial cortex (PMC) and medial temporal lobes (MTL) are two brain regions particularly vulnerable in Alzheimer's disease (AD). We have reviewed the spatiotemporal patterns of amyloid-β and tau accumulation, local MTL functional ...
Mild Cognitive Impairment with a High Risk of Progression to Alzheimer's Disease Dementia (MCI-HR-AD): Effect of Souvenaid® Treatment on Cognition and 18F-FDG PET Scans [0.03%]
具有高风险进展为阿尔茨海默病性痴呆的轻度认知障碍（MCI-HR-AD）：Souvenaid®治疗对认知和18F-FDG正电子发射断层扫描的影响
Maria Sagrario Manzano Palomo,Belen Anaya Caravaca,Maria Angeles Balsa Bretón et al.
Maria Sagrario Manzano Palomo et al.
Background: Previous studies have shown that Souvenaid (medical food) can have benefits on memory, cognition, and function in early Alzheimer's disease (AD) and mild cognitive impairment (MCI). ...
Pre-Clinical Safety and Efficacy Evaluation of Amytrap, a Novel Therapeutic to Treat Alzheimer's Disease [0.03%]
治疗阿尔茨海默病的新型药物Amytrap的安全性和有效性试验的临床前评估研究
Omkar Gandbhir,Pazhani Sundaram
Omkar Gandbhir
Alzheimer's disease (AD) is the most common cause of dementia. Amyloid-β (Aβ42) is implicated in AD pathogenesis. We have designed a non-immune based proprietary therapeutic, called Amytrap, a conjugate containing a retro-inverso peptide,...
Mining Clinical Case Reports to Identify New Lines of Investigation in Alzheimer's Disease: The Curious Case of DNase I [0.03%]
挖掘临床病例报告发现阿尔茨海默病新的研究方向：DNase I的案例故事
Neil R Smalheiser
Neil R Smalheiser
Mining the case report literature identified an intriguing, yet neglected finding: Deoxyribonuclease I (DNase I) as a possible treatment for Alzheimer's disease. This finding is speculative, both because it is based on one patient, and beca...
Curcumin Ameliorates the Impaired Insulin Signaling Involved in the Pathogenesis of Alzheimer's Disease in Rats [0.03%]
姜黄素通过改善参与阿尔茨海默病发病机制的受损胰岛素信号通路来缓解病情
Tushar Kanti Das,Swarup Kumar Chakrabarti,Ihsan Nazurah Zulkipli et al.
Tushar Kanti Das et al.
To date, dysregulation of the insulin signaling pathway in the brain has not been demonstrated unequivocally in Alzheimer's disease (AD). The purpose of the study was to examine the possible dysregulation of insulin signaling pathway in an ...