Protocol of Aerobic Exercise and Cognitive Health (REACH): A Pilot Study [0.03%]
有氧运动与认知健康协议（REACH）：一项试点研究
Julian M Gaitán,Elizabeth A Boots,Ryan J Dougherty et al.
Julian M Gaitán et al.
A growing body of evidence supports that aerobic exercise can decrease the risk of future cognitive impairment and Alzheimer's disease (AD). There is a pressing need to rigorously determine whether cognitively normal yet at-risk individuals...
Sildenafil for the Treatment of Alzheimer's Disease: A Systematic Review [0.03%]
治疗阿尔茨海默病的西地那非：系统性综述
Owen Sanders
Owen Sanders
Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in Alzheimer's disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is upregulated. Sildenafil inhibits PDE5 and increases cGMP levels. Integrating pr...
Modelling Modifiable Predictors of Age-Related Cognitive Decline: Exercise, Aortic Stiffness, and the Importance of Physical Fitness [0.03%]
运动、主动脉僵硬度和体能对认知老化的影响及改善
Greg Kennedy,Denny Meyer,Roy J Hardman et al.
Greg Kennedy et al.
Background: Previous modelling found that fitness and aortic stiffness both independently predicted spatial working memory (SWM) performance in older people. There is also evidence that greater engagement in moderate inte...
Aging-Related and Gender Specific Albumin Misfolding in Alzheimer's Disease [0.03%]
阿尔茨海默病中与衰老及性别相关的白蛋白异常聚集现象
Francis H C Tsao,Jill N Barnes,Amy Amessoudji et al.
Francis H C Tsao et al.
Aging-related protein misfolding and aggregation may play critical roles in the pathogenesis of numerous diseases. In the brain, extracellular aggregated amyloid-β (Aβ) is closely related to the death of neurons in individuals with Alzhei...
A Case of Logopenic Variant of Primary Progressive Aphasia with Parkinsonism and Anosmia [0.03%]
一名以帕金森病和嗅觉减退为主要表现的原发性进行性失语PV-PPA患者病例报告
Shoichi Sasaki
Shoichi Sasaki
A 69-year-old right-handed woman developed difficulty naming objects and word-finding. The clinical features of language disorder and predominant atrophy on MRI and predominant hypoperfusion on 123I-IMP SPECT in the left temporo-parietal ju...
Identification of Superficial White Matter Abnormalities in Alzheimer's Disease and Mild Cognitive Impairment Using Diffusion Tensor Imaging [0.03%]
基于扩散张量成像的老年痴呆症和轻度认知障碍患者浅表白质异常的识别
Bahare Bigham,Seyed Amir Zamanpour,Fariba Zemorshidi et al.
Bahare Bigham et al.
Background: Diffusion tensor imaging (DTI) estimates the microstructural alterations of the brain, as a magnetic resonance imaging (MRI)-based neuroimaging technique. Prior DTI studies reported decreased structural integr...
Interdisciplinary and Transdisciplinary Perspectives: On the Road to a Holistic Approach to Dementia Prevention and Care [0.03%]
跨学科和多学科视角：走向全面的痴呆预防与照护模式之路
Francisca S Rodriguez Then,Jonathan Jackson,Caitlin Ware et al.
Francisca S Rodriguez Then et al.
Dementia, of which the most frequent form is Alzheimer's disease, is a chronic and terminal condition with multi-factorial causes and numerous consequences on a patient's life. Combining perspectives from different disciplines seems necessa...
Role of Fluid Biomarkers and PET Imaging in Early Diagnosis and its Clinical Implication in the Management of Alzheimer's Disease [0.03%]
液体生物标志物和正电子发射断层扫描在阿尔茨海默病早期诊断及临床管理中的作用
Shahul Hameed,Jong-Ling Fuh,Vorapun Senanarong et al.
Shahul Hameed et al.
Clinical diagnosis of Alzheimer's disease (AD) is based on symptoms; however, the challenge is to diagnose AD at the preclinical stage with the application of biomarkers and initiate early treatment (still not widely available). Currently, ...
Apolipoprotein A1 in Cerebrospinal Fluid Is Insufficient to Distinguish Alzheimer's Disease from Other Dementias in a Naturalistic, Clinical Setting [0.03%]
脑脊液中载脂蛋白A1无法区分阿尔茨海默病和其他类型的痴呆症
Nicolai Maximilian Stoye,Patrick Jung,Malena Dos Santos Guilherme et al.
Nicolai Maximilian Stoye et al.
Apolipoprotein A1 (ApoA1) is the major protein component of the high-density lipoprotein and involved in cholesterol transport. Disruption of cholesterol homeostasis has been identified as a contributing factor for Alzheimer's disease (AD)....
Karel Kostev,Galina Osina
Karel Kostev
Background: Studies on prevalence or the therapy of dementia are rare or non-existent in Russia. Objective: The purpose of this study w...