Engaging Patients to Design the Systematic Multi-Domain Alzheimer's Risk Reduction Trial (SMARRT) Intervention: Findings from a Web-Based Survey [0.03%]
通过网络调查让患者参与设计系统多领域阿尔茨海默病风险降低试验(SMARRT)干预的发现
Zachary A Marcum,Dori Rosenberg,Deborah E Barnes et al.
Zachary A Marcum et al.
We administered a web-based survey to a convenience sample of 561 patients in a large health system to assess patient attitudes toward dementia prevention in the context of designing a multi-domain Alzheimer's risk reduction intervention. T...
A Comprehensive, Multi-Modal Strategy to Mitigate Alzheimer's Disease Risk Factors Improves Aspects of Metabolism and Offsets Cognitive Decline in Individuals with Cognitive Impairment [0.03%]
综合性多模式策略改善代谢并抵消认知障碍患者的认知衰退风险因素效果的研究
Ginger Schechter,Gajendra Kumar Azad,Rammohan Rao et al.
Ginger Schechter et al.
Background: Alzheimer's disease (AD) is a chronic condition that progresses over time. While several therapeutic approaches have been developed, none have substantially altered disease progression. One explanation is that...
Neurologic and Immunologic Complications of COVID-19: Potential Long-Term Risk Factors for Alzheimer's Disease [0.03%]
新冠肺炎的神经和免疫并发症：阿兹海默病的潜在长期风险因素
Jack C Lennon
Jack C Lennon
The COVID-19 pandemic has been met with studies on risk factors, characteristics, and clinical course. Among these characteristics are neurologic symptoms, which may provide improved insight into the mechanisms of this novel virus and the b...
Phosphodiesterase Inhibitors for Alzheimer's Disease: A Systematic Review of Clinical Trials and Epidemiology with a Mechanistic Rationale [0.03%]
黄素化酶抑制剂治疗阿尔茨海默病的临床试验和流行病学的系统评价及机理分析
Owen Sanders,Lekshmy Rajagopal
Owen Sanders
Background: Preclinical studies, clinical trials, and reviews suggest increasing 3',5'-cyclic adenosine monophosphate (cAMP) and 3',5'-cyclic guanosine monophosphate (cGMP) with phosphodiesterase inhibitors is disease-mod...
Benjamin Sinyor,Jocelyn Mineo,Christopher Ochner
Benjamin Sinyor
The World Health Organization refers to Alzheimer's disease (AD) as a global health priority. As the average age of the world's population is increasing, so too is the rate of AD. There are an estimated 47 million people globally who have b...
Initial Physician Experience with [18F]Flutemetamol Amyloid PET Imaging Following Availability for Routine Clinical Use in Japan [0.03%]
[18F]氟氯甲酮amyloid pet显像在日本投入常规临床应用初期医生的使用体验
Naoya Hattori,Paul Sherwin,Gill Farrar
Naoya Hattori
Background: Brain amyloid is a neuropathological hallmark of Alzheimer's disease (AD). By visualizing brain amyloid, positron emission tomography (PET) may influence the diagnostic assessment and management of patients wi...
The Complex Maze of the Informed Consent Process: Helping to Improve Comprehension in Clinical Trial Participants with Alzheimer's Disease [0.03%]
知情同意过程的复杂迷宫：帮助改善阿尔茨海默病临床试验参与者的理解能力
Louis X Wong,Gail M Bloom,Bryant Chee
Louis X Wong
We intend for this article to provide a foundation toward the creation of a more patient-centric approach to the informed consent process. Our overall objectives are to promote ethical clinical research standards and procedures toward enhan...
Validation of the Neuropsychiatric Inventory Based on Item Response Theory [0.03%]
基于项目反应理论的神经精神问卷评定效度研究
Kenji Wada-Isoe,Takashi Kikuchi,Yumi Umeda-Kameyama et al.
Kenji Wada-Isoe et al.
Background: The Neuropsychiatric Inventory (NPI) is a widely used scale for the assessment of the behavioral and psychological symptoms of dementia (BPSD). We previously developed a novel dementia scale, the ABC dementia ...
Picornavirus Identified in Alzheimer's Disease Brains: A Pathogenic Path? [0.03%]
阿尔茨海默病脑中鉴定出的小RNA病毒：致病之路？
Bo Niklasson,Lars Lindquist,William Klitz;Netherlands Brain Bank;Elisabet Englund
Bo Niklasson
We investigated formalin-fixed postmortem brain tissue from the hippocampus region of 18 AD cases and 11 age-matched controls using a polyclonal antibody against Ljungan virus (LV) capsid protein 1. Evidence of a LV antigen was found in all...
Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer's Disease [0.03%]
阿尔茨海默病中与排序蛋白相关的受体1的作用机制研究
Karissa Barthelson,Morgan Newman,Michael Lardelli
Karissa Barthelson
Sortilin-related receptor 1 (SORL1) encodes a large, multi-domain containing, membrane-bound receptor involved in endosomal sorting of proteins between the trans-Golgi network, endosomes and the plasma membrane. It is genetically associated...