The Role of Nutrition and Inflammation on Cognition in a High-Risk Group for Alzheimer's Disease [0.03%]
营养和炎症在阿尔茨海默病高危群体的认知中的作用
Jordan M Jackson,Allison A Bay,Jolie Denise Barter et al.
Jordan M Jackson et al.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disease. Treatments are necessary to target people at high risk for AD. Inflammation, particularly tumor necrosis factor alpha (TNFα), appears to be a...
Race- and Sex-Based Disparities in Alzheimer's Disease Clinical Trial Enrollment in the United States and Canada: An Indigenous Perspective [0.03%]
美国和加拿大阿尔茨海默病临床试验入组中的种族和性别差异：土著视角
Nancy L Olson,Benedict C Albensi
Nancy L Olson
Randomized clinical trials (RCT) involve labor-intensive, highly regulated, and controlled processes intended to transform scientific concepts into clinical outcomes. To be effective and targeted, it is imperative they include those populat...
Normative Data for the Symbol Digit Modalities Test in Older White Australians and Americans, African-Americans, and Hispanic/Latinos [0.03%]
老年人群中白人澳大利亚人和美国人，非裔美国人以及西班牙/拉丁美洲人在符号数字测试中的标准化数据
Joanne Ryan,Robyn L Woods,Carlene J Britt et al.
Joanne Ryan et al.
Background: Processing speed, which can be assessed using the Symbol Digit Modalities Test (SDMT), is central to many brain functions. Processing speed declines with advanced age but substantial impairments are indicative...
Long-Term, All-Day Exposure to Circadian-Effective Light Improves Sleep, Mood, and Behavior in Persons with Dementia [0.03%]
长期全天候的生理节奏有效光照改善了痴呆症患者的睡眠，情绪和行为
Mariana G Figueiro,Levent Sahin,Michael Kalsher et al.
Mariana G Figueiro et al.
Background: Persons with Alzheimer's disease and related dementias (ADRD) frequently experience sleep-wake (circadian) cycle disturbances that lead them to remain awake at night, causing stress and fatigue for families an...
Vaccination Prevented Short-Term Memory Loss, but Deteriorated Long-Term Spatial Memory in Alzheimer's Disease Mice, Independent of Amyloid-β Pathology [0.03%]
疫苗防止了阿尔茨海默病小鼠的短期记忆丧失，但恶化了长期空间记忆，与淀粉样蛋白-β病理无关
Klaske Oberman,Leonie Gouweleeuw,Peter Hoogerhout et al.
Klaske Oberman et al.
Background: Soluble oligomeric amyloid-β (Aβ), rather than Aβ plaques, seems to be the culprit in Alzheimer's disease (AD). Accordingly, a new concept vaccine of small cyclic peptide conjugates, selectively targeting o...
Gliosis Precedes Amyloid-β Deposition and Pathological Tau Accumulation in the Neuronal Cell Cycle Re-Entry Mouse Model of Alzheimer's Disease [0.03%]
在阿尔茨海默病的神经元细胞周期再进入小鼠模型中胶质增生先于淀粉样蛋白-β沉积和异常tau积聚出现
Kevin H J Park,Tomás Barrett
Kevin H J Park
Background: The presence of cell cycle markers in postmortem Alzheimer's disease (AD) brains suggest a potential role of cell cycle activation in AD. It was shown that cell cycle activation in postmitotic neurons in mice ...
Attempt to Predict A/T/N-Based Alzheimer's Disease Cerebrospinal Fluid Biomarkers Using a Peripheral Blood DNA Methylation Clock [0.03%]
尝试使用外周血DNA甲基化钟预测基于A/T/N的阿尔茨海默病脑脊液生物标志物
Kenichiro Sato,Tatsuo Mano,Kazushi Suzuki et al.
Kenichiro Sato et al.
Background: Although aging is the strongest risk factor for the development of Alzheimer's disease (AD), it remains uncertain if the blood DNA methylation clock, which reflects the effect of biological aging on DNA methyl...
Andrew C Robinson,Yvonne S Davidson,Federico Roncaroli et al.
Andrew C Robinson et al.
While many studies have examined the associations between APOE genotype and mortality, findings have often been conflicting and it remains unclear whether APOE genotype affects longevity. Using selected individuals from the Manchester arm o...
Ge Wang,Wei Li
Ge Wang
Background: Diabetes has been shown as a risk factor for cognitive impairments. However, it is still not clear about the time course of developing abnormal cognition in those with diabetes especially if the morbidity acce...
Dementia and COVID-19 Lockdown: More Than a Double Blow for Patients and Caregivers [0.03%]
痴呆症和COVID-19封城：对病人和护理者而言远非单一重击
Raffaella Migliaccio,Arabella Bouzigues
Raffaella Migliaccio
In dementia research and in clinical practice, the COVID-19 pandemic represents an important challenge, not only for neurological staff and researchers, but above all for patients and their caregivers. It is important that the medical staff...