Borrelidin from Saltern-Derived Halophilic Nocardiopsis sp. Dissociates Amyloid- β and Tau Fibrils [0.03%]
盐场诺卡菌孢子体产生的一种抗生物质硼雷啶素可分解淀粉样蛋白-β和tau原纤维
Jisu Shin,Seung-Hoon Yang,Young Eun Du et al.
Jisu Shin et al.
Background: Alzheimer's disease (AD) is characterized by the aggregation of two pathological proteins, amyloid-β (Aβ) and tau, leading to neuronal and cognitive dysfunction. Clearance of either Aβ or tau aggregates by ...
Sex as a Risk Factor for Developing Cognitive Impairments in National Alzheimer's Coordinating Center Participants [0.03%]
关于全国阿尔茨海默病协调中心参与者性行为的一项研究：一项针对认知损伤的风险因素的研究
Ge Wang,Wei Li
Ge Wang
Background: It is inconclusive on how sex affects the risk of developing mild cognitive impairment (MCI) or dementia. Objective: To inv...
The Vagal Autonomic Pathway of COVID-19 at the Crossroad of Alzheimer's Disease and Aging: A Review of Knowledge [0.03%]
新冠病毒迷走自主神经路径在阿尔茨海默病和衰老的交叉路口：知识回顾
Claire-Marie Rangon,Slavica Krantic,Emmanuel Moyse et al.
Claire-Marie Rangon et al.
Coronavirus Disease 2019 (COVID-19) pandemic-triggered mortality is significantly higher in older than in younger populations worldwide. Alzheimer's disease (AD) is related to aging and was recently reported to be among the major risk facto...
Correlative Microscopy to Localize and Characterize Iron Deposition in Alzheimer's Disease [0.03%]
相关显微镜技术在阿尔茨海默病中铁沉积定位和表征中的应用
Steven J Madsen,Phillip S DiGiacomo,Yitian Zeng et al.
Steven J Madsen et al.
Background: Recent evidence suggests that the accumulation of iron, specifically ferrous Fe2+, may play a role in the development and progression of neurodegeneration in Alzheimer's disease (AD) through the production of ...
Testing the Cognitive Reserve Index Questionnaire in an Alzheimer's Disease Population [0.03%]
阿尔茨海默病患者认知储备指数问卷检测
Asabe E Garba,George T Grossberg,Kimberly R Enard et al.
Asabe E Garba et al.
Background: Alzheimer's disease (AD) is the 6th leading cause of death in the United States and has no cure or progression prevention. The Cognitive Reserve (CR) theory poses that constant brain activity earlier in life l...
Porphyromonas gingivalis is a Strong Risk Factor for Alzheimer's Disease [0.03%]
牙龈卟啉单胞菌是阿尔茨海默病强风险因素
Shalini Kanagasingam,Sasanka S Chukkapalli,Richard Welbury et al.
Shalini Kanagasingam et al.
Porphyromonas gingivalis (P. gingivalis) is one of the several important bacterial pathogens associated with the sporadic Alzheimer's disease (AD). Different serotypes are either capsulated or are non-capsulated. It has been demonstrated th...
Evaluating Additional Aspects of Muscle Function with a Digital Handgrip Dynamometer and Accelerometer for Cognitive Functioning in Older Adults: A Pilot Study [0.03%]
老年人认知功能的数字握力计和加速仪肌肉功能附加方面的评估：一项试点研究
Lukus Klawitter,Sean J Mahoney,Lindsey Dahl et al.
Lukus Klawitter et al.
Handgrip dynamometers are used to assess handgrip strength (HGS), and low HGS is linked to poor cognitive function. Although HGS is a reliable measure of muscle function, it is only measuring maximal grip force. Other aspects of muscle func...
Dysregulation of Insulin-Linked Metabolic Pathways in Alzheimer's Disease: Co-Factor Role of Apolipoprotein E ɛ 4 [0.03%]
阿尔茨海默病中的胰岛素相关代谢通路失调及其与载脂蛋白Eɛ 4的协同作用
James Robbins,Oriol Busquets,Ming Tong et al.
James Robbins et al.
Background: Brain insulin resistance and deficiency are well-recognized abnormalities in Alzheimer's disease (AD) and likely mediators of impaired energy metabolism. Since apolipoprotein E (APOE) is a major risk factor fo...
Distinct Cognitive Trajectories in Late Life and Associated Predictors and Outcomes: A Systematic Review [0.03%]
独特认知轨迹及其相关影响因素和结局的系统评价：基于老龄人群的证据
Zimu Wu,Aung Zaw Zaw Phyo,Tagrid Al-Harbi et al.
Zimu Wu et al.
Background: Cognitive aging is a dynamic process in late life with significant heterogeneity across individuals. Objective: To review t...
Hallucinations in a Patient with Alzheimer's Disease During the COVID-19 Crisis: A Case Study [0.03%]
新冠疫情期间一名阿尔茨海默病患者的幻觉：病例研究
Mohamad El Haj,Frank Larøi,Karim Gallouj
Mohamad El Haj
While social distancing may be deemed necessary in order to avoid COVID-19 infections, the lockdown may impact mental health of patients with Alzheimer's disease (AD). We present a case study involving hallucinations in a patient with AD wh...