Potential Virus Involvement in Alzheimer's Disease: Results from a Phase IIa Trial Evaluating Apovir, an Antiviral Drug Combination [0.03%]
阿尔茨海默病潜在病毒病因的研究：评估抗病毒药物组合Apovir的二期临床试验结果
Nina Lindblom,Lars Lindquist,Jacob Westman et al.
Nina Lindblom et al.
Background: Accumulating data suggest infectious agents are involved in Alzheimer's disease (AD). The two primary aims of this trial were to assess safety and efficacy of an antiviral drug combination on AD progression. ...
Interacting Models of Amyloid-β and Tau Proteins: An Approach to Identify Drug Targets in Alzheimer's Disease [0.03%]
用于阿尔茨海默病药物靶点鉴定的淀粉样蛋白-β和tau蛋白质相互作用模型方法研究
Khadgawat Priya,J M Siddesha,Shashank Dharini et al.
Khadgawat Priya et al.
Alzheimer's disease (AD) is the primary cause of dementia affecting millions each year across the world, though still remains incurable. This might be attributed to the lack of knowledge about the associated proteins, their cellular and mol...
In-Frame and Frameshift Mutations in Zebrafish Presenilin 2 Affect Different Cellular Functions in Young Adult Brains [0.03%]
斑马鱼早老素2的内读和框移突变在年轻成年大脑中影响不同的细胞功能
Karissa Barthelson,Stephen Martin Pederson,Morgan Newman et al.
Karissa Barthelson et al.
Background: Mutations in PRESENILIN 2 (PSEN2) cause early onset familial Alzheimer's disease (EOfAD) but their mode of action remains elusive. One consistent observation for all PRESENILIN gene mutations causing EOfAD is ...
Is There a Characteristic Autonomic Response During Outbursts of Combative Behavior in Dementia Patients? [0.03%]
痴呆患者攻击性行为突发时自主神经反应的特点是什么？
Curtis K Deutsch,Pooja P Patnaik,Frank A Greco
Curtis K Deutsch
We sought to determine whether skin conductance level could warn of outbursts of combative behavior in dementia patients by using a wristband device. Two outbursts were captured and are reported here. Although no physiologic parameter measu...
Protein and Imaging Biomarkers in the Eye for Early Detection of Alzheimer's Disease [0.03%]
眼科蛋白质和影像生物标志物用于阿尔茨海默病的早期诊断
Shaunt Fereshetian,Joshua S Agranat,Nicole Siegel et al.
Shaunt Fereshetian et al.
Alzheimer's disease (AD) is one of the most common causes of dementia worldwide. Although no formal curative therapy exists for the treatment of AD, considerable research has been performed to identify biomarkers for early detection of this...
More Atypical than Atypical Alzheimer's Disease Phenotypes: A Treviso Dementia (TREDEM) Registry Case Report [0.03%]
不典型的老年性痴呆综合征中的非典型型：一项来自特雷维索痴呆登记处的病例报告
Maurizio Gallucci,Anna Paola Mazzarolo,Lucia Focella et al.
Maurizio Gallucci et al.
Background: A 57-year-old right-handed man was admitted to the Treviso Memory Clinic due to the presence of memory forgetfulness, repetition of the same questions, episodes of confusion, initial difficulties in performing...
Creative Art Therapy as a Non-Pharmacological Intervention for Dementia: A Systematic Review [0.03%]
创意艺术疗法作为非药物干预治疗痴呆症的系统性综述
Shayla Y M Emblad,Elizabeta B Mukaetova-Ladinska
Shayla Y M Emblad
Background: Non-pharmacological therapies have been shown to be effective in managing challenging behavior in people with dementia. However, the efficacy of art therapy has yet to be determined. ...
Alzheimer's Disease and Empathic Abilities: The Proposed Role of the Cingulate Cortex [0.03%]
顶叶皮质与阿尔茨海默病及换位思考能力的关系
Marina Ávila-Villanueva,Jaime Gómez-Ramírez,Jesús Ávila et al.
Marina Ávila-Villanueva et al.
In recent years there has been increasing interest in examining the role of empathic abilities in Alzheimer's disease (AD). Empathy, the ability to understand and share another person's feelings, implies the existence of emotional and cogni...
Hojune E Chung,Jessica Chen,Dhairyasheel Ghosalkar et al.
Hojune E Chung et al.
Background: While an association between atherosclerosis and dementia has been identified, few studies have assessed the longitudinal relationship between aortic valve calcification (AVC) and cognitive impairment (CI). ...
Phase II (NAVIGATE-AD study) Results of LY3202626 Effects on Patients with Mild Alzheimer's Disease Dementia [0.03%]
LY3202626治疗轻度阿尔茨海默病痴呆患者II期（NAVIGATE-AD研究）结果
Albert C Lo,Cynthia Duggan Evans,Michele Mancini et al.
Albert C Lo et al.
Background: LY3202626 is a small molecule inhibitor of β-site amyloid precursor protein cleaving enzyme (BACE)1 shown to reduce amyloid-β (Aβ)1-40 and Aβ1-42 concentrations in plasma and cerebrospinal fluid developed ...