Molecular sabotage of hippocampal synaptic plasticity by amyloid-β in Alzheimer's disease: A narrative review [0.03%]
阿尔茨海默病中淀粉样蛋白-β破坏海马区突触可塑性的分子机制：综述性文章
Zahra Behroozi,Hedyeh Askarpour,Yousef Baghcheghi
Zahra Behroozi
This narrative review aims to synthesize and critically evaluate the complex molecular mechanisms by which amyloid-β (Aβ) accumulation disrupts hippocampal synaptic plasticity, the cellular cornerstone of learning and memory in Alzheimer'...
Identification of potential short-chain fatty acid biomarkers in Alzheimer's disease through bioinformatics analysis [0.03%]
通过生物信息学分析识别阿尔茨海默病中的潜在短链脂肪酸生物标志物
Yuting Yang,Yuchen Meng,Miaomiao Li et al.
Yuting Yang et al.
Background: Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder. Accumulating evidence suggests that short-chain fatty acids (SCFAs) can regulate the central nervous system, thereby affecting cogniti...
Unraveling the molecular links: Alzheimer's disease-induced mechanisms of memory impairment: A narrative review [0.03%]
解开分子联系：阿尔茨海默病引起的记忆障碍机制：叙述性综述
Yousef Baghcheghi,Fateme Razazpour,Mola Mohammadi et al.
Yousef Baghcheghi et al.
Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive memory impairment and cognitive decline, significantly impacting the quality of life for millions worldwide. Understanding the intricate molecular...
Prediction of clinical and language changes after a single session of repetitive transcranial magnetic stimulation in primary progressive aphasia: A machine learning approach [0.03%]
机器学习预测原发性进行性失语患者单次重复经颅磁刺激后的临床和语言变化
Carlos Moral Rubio,Lucía Fernández-Romero,Paloma Balugo et al.
Carlos Moral Rubio et al.
Background: Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive therapeutic option for primary progressive aphasia (PPA) and Alzheimer's disease among other neurological conditions. ...
The diagnostic value of plasma phosphorylated tau 181 in Alzheimer's disease within the Chinese population: A systematic review and meta-analysis [0.03%]
血浆磷酸化tau蛋白181在阿尔茨海默病中的诊断价值：系统评价和 meta 分析
Keqiang Yan,Haiyan Li,Shuxin He et al.
Keqiang Yan et al.
Background: Among all related biomarkers, plasma phosphorylated tau (p-tau181) has demonstrated strong diagnostic performance in the very early stages of Alzheimer's disease (AD), showing significant differences between A...
Osteoporosis-mediated exacerbation of the amyloid-β pathology: Involvement of serum calcium [0.03%]
骨质疏松介导的淀粉样蛋白-β病理学恶化：血清钙的作用
Zhe-Sheng Zhang,Rong-Rong Lin,Xu Liu et al.
Zhe-Sheng Zhang et al.
Alzheimer's disease (AD) and osteoporosis (OP) are two common age-related degenerative diseases with similar epidemiological characteristics, yet their complex relationship and specific mechanistic intersections remain unclear. In this stud...
Pilot: Salivary lactoferrin as a potential preclinical Alzheimer's disease biomarker [0.03%]
唾液溶菌酶作为潜在的临床前阿尔茨海默病生物标志物
Bruno L Hammerschlag,Brittany Butts,Kelly Ds Likos et al.
Bruno L Hammerschlag et al.
Alzheimer's disease (AD) research increasingly emphasizes accessible biomarkers for early detection. Lactoferrin, an iron-binding glycoprotein present in saliva, has been associated with AD pathology with mixed results. In this pilot study,...
Baseline characteristics of patients with early Alzheimer's disease enrolled in the pivotal trial of low-intensity pulsed ultrasound (LIPUS-AD) [0.03%]
低强度脉冲超声(LIPUS-AD)关键试验中早期阿尔茨海默病患者的基线特征
Hiroaki Shimokawa,Masahiro Akishita,Takashi Asada et al.
Hiroaki Shimokawa et al.
Background: We demonstrated that low-intensity pulsed ultrasound (LIPUS) therapy tended to ameliorate cognitive declines in patients with early Alzheimer's disease (AD) in the pilot trial. Thus, we have started the pivota...
Higher cerebellum florbetapir uptake in cerebral amyloid angiopathy compared to Alzheimer's disease: A dual florbetapir and FDG PET study [0.03%]
与阿尔茨海默病相比，脑淀粉样血管病的小脑florbetapir摄取量更高：双氟乙基锁酮和FDG正电子发射体层摄影研究
Yuhui Sha,Chenhao Jia,Menglin Liang et al.
Yuhui Sha et al.
Background: Amyloid-β (Aβ) is the primary amyloidogenic protein involved in various diseases associated with cognitive dysfunction, including Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA). ...
Interaction of insula and hippocampus in memory dysfunction in Alzheimer's disease [0.03%]
阿尔茨海默病记忆障碍中岛叶和海马的功能连接异常
Michelle M Coleman,Marc W Haut,Camila Vieira Ligo Teixeira et al.
Michelle M Coleman et al.
The insula, classically linked with emotion and perception, has recently been associated with memory function in Alzheimer's disease (AD). However, its role in memory remains unclear. This study investigated whether the insula contributes d...