Perspectives on the Role of APOE4 as a Therapeutic Target for Alzheimer's Disease [0.03%]
APOE4作为阿尔茨海默病治疗靶点的作用视角
Kavita Patel,Siwangi Srivastava,Shikha Kushwah et al.
Kavita Patel et al.
Alzheimer's disease (AD) is a neurodegenerative disease that is coupled with chronic cognitive dysfunction. AD cases are mostly late onset, and genetic risk factors like the Apolipoprotein E (APOE) play a key role in this process. APOE ɛ2,...
Is There Any Evidence of Monocytes Involvement in Alzheimer's Disease? A Pilot Study on Human Postmortem Brain [0.03%]
关于单核细胞是否参与阿尔茨海默病的证据几何？人脑组织研究初探
Camelia-Maria Monoranu,Tim Hartmann,Sabrina Strobel et al.
Camelia-Maria Monoranu et al.
Background: The role of neuroinflammation has become more evident in the pathogenesis of neurodegenerative diseases. Increased expression of microglial markers is widely reported in Alzheimer's disease (AD), but much less...
Depression Mediates the Association Between Occupational Complexity and Late-Life Cognition in Hispanics [0.03%]
抑郁症在职业复杂性与拉丁裔老年人认知功能之间的中介作用
Camilo Posada Rodríguez,Sofía Rodríguez-Araña,Diana C Oviedo et al.
Camilo Posada Rodríguez et al.
There is a dearth of research in Latin America regarding risk and protective factors affecting older adults' cognition. This study aimed to investigate the factors mediating the association between occupational complexity and late-life cogn...
Use of Benzodiazepines and Z-Drugs in Nursing Home Residents with Dementia: Prevalence and Appropriateness [0.03%]
苯二氮卓类和Z药物在痴呆症疗养院住户中的使用：发生率与适用性分析
Dirk O C Rijksen,Sytse U Zuidema,Esther C de Haas
Dirk O C Rijksen
Background: Guidelines worldwide recommend restricted prescription of benzodiazepine receptor agonists (BZRAs), i.e., benzodiazepines and Z-drugs, for the treatment of dementia-associated behavioral and psychological symp...
Molecular Investigation of the Unfolded Protein Response in Select Human Tauopathies [0.03%]
人类Tau病中未折叠蛋白反应的分子研究
Aleksandra P Pitera,Iain J Hartnell,Lucy Scullard et al.
Aleksandra P Pitera et al.
Background: Tauopathies are a group of neurodegenerative diseases associated with the accumulation of misfolded tau protein. The mechanisms underpinning tau-dependent proteinopathy remain to be elucidated. A protein quali...
A Novel Intervention for Management of Behavioral and Psychological Symptoms of Dementia in Nursing Home Communal Areas: Results of a Small-Scale Pilot Trial [0.03%]
一项针对护理人员共公区域的精神疾病行为干预的新方法：小型试点工作试点结果
Gloria Gutman,Avantika Vashisht,Taranjot Kaur et al.
Gloria Gutman et al.
Background: Behavioral and psychological symptoms of dementia (BPSD) exhibited by persons with dementia (PwD) in nursing home communal areas are generally managed by segregation and/or pharmacological interventions. ...
A Non-Invasive Determination of Ketosis-Induced Elimination of Chronic Daytime Somnolence in a Patient with Late-Stage Dementia (Assessed with Type 3 Diabetes): A Potential Role of Neurogenesis [0.03%]
一种非侵入性测定酮体诱导消除晚期痴呆患者慢性日间嗜睡的方法（伴有3型糖尿病）：神经发生的潜在作用
Leslie A Lewis,Carl M Urban,Sami A Hashim
Leslie A Lewis
Background: The study involved a female patient diagnosed with late-stage dementia, with chronic daytime somnolence (CDS) as a prominent symptom. Objectiv...
Computational Approaches for Supporting Combination Therapy in the Post-Aducanumab Era in Alzheimer's Disease [0.03%]
阿杜那单抗后的阿尔茨海默病组合疗法的计算方法支持
Hugo Geerts,Piet van der Graaf
Hugo Geerts
With the approval of aducanumab on the "Accelerated Approval Pathway" and the recognition of amyloid load as a surrogate marker, new successful therapeutic approaches will be driven by combination therapy as was the case in oncology after t...
Altered Cerebrospinal Fluid Exosomal microRNA Levels in Young-Onset Alzheimer's Disease and Frontotemporal Dementia [0.03%]
年轻型阿尔茨海默病和额颞叶痴呆的脑脊液外泌体microRNA水平改变
Yi Jayne Tan,Benjamin Y X Wong,Ramanathan Vaidyanathan et al.
Yi Jayne Tan et al.
Background: micro-RNAs (miRNAs) are stable, small, non-coding RNAs enriched in exosomes. Their variation in levels according to different disease etiologies have made them a promising diagnostic biomarker for neurodegener...
Quality of Life and Caregiver Burden of Alzheimer's Disease Among Community Dwelling Patients in Europe: Variation by Disease Severity and Progression [0.03%]
欧洲社区居住的阿尔茨海默病患者的生活质量和护理负担：疾病严重程度和进展的差异
Lutz Froelich,Albert Lladó,Rezaul K Khandker et al.
Lutz Froelich et al.
Background: Alzheimer's disease (AD) is a significant burden on patients and caregivers. How this burden increases as disease progresses has not been well researched. ...