Intracerebral Infection with E. coli Impairs Spatial Learning and Induces Necrosis of Hippocampal Neurons in the Tg2576 Mouse Model of Alzheimer's Disease [0.03%]
颅内感染大肠杆菌损害阿尔茨海默病tg2576小鼠空间学习并诱导海马神经元坏死
Sandra Schütze,Anika Döpke,Benedikt Kellert et al.
Sandra Schütze et al.
Background: In patients with Alzheimer's disease (AD), bacterial infections are often associated with a cognitive decline. Animal models of genuine acute infections with viable bacteria which induce deterioration of neuro...
Cognitive and Functional Abilities in an Older Adult Veteran Before and After Contracting COVID-19 [0.03%]
新冠肺炎感染对老年退伍军人认知功能的影响
Ronald Okolichany,Prasad R Padala,Scott Mooney
Ronald Okolichany
Background: A 76-year-old male Veteran with a historical diagnosis of mild cognitive impairment was assessed at baseline and follow-up as part of two separate, ongoing studies. He was diagnosed with COVID-19 during the in...
The Added Value of Cerebrospinal Fluid Neurofilament Light Chain to Existing Diagnostic Methods and Biomarkers in a Mixed Memory Clinic Cohort of Consecutive Patients [0.03%]
脑脊液神经丝轻链标志物在混合型记忆门诊患者中的诊断价值研究
Helena Sophia Gleerup,Anja Hviid Simonsen,Peter Høgh
Helena Sophia Gleerup
The added value of neurofilament light chain (NfL) to the existing diagnostic methods is unknown, although a plethora of studies have shown increased levels in cerebrospinal fluid (CSF) and blood in many neurodegenerative and neurological d...
The Relationship Between Hearing and Mild Behavioral Impairment and the Influence of Sex: A Study of Older Adults Without Dementia from the COMPASS-ND Study [0.03%]
听力与轻度行为障碍之间的关系以及性别影响：来自COMPASS-ND研究的无痴呆老年人的研究
Penny Gosselin,Dylan X Guan,Hung-Yu Chen et al.
Penny Gosselin et al.
Background: Hearing loss and mild behavioral impairment (MBI), both non-cognitive markers of dementia, can be early warning signs of incident cognitive decline. ...
Telehealth Literacy as a Social Determinant of Health: A Novel Screening Tool to Support Vulnerable Patient Equity [0.03%]
远程医疗素养作为一种健康的社会决定因素：一种支持弱势患者公平性的新型筛查工具
Monica Gillie,Diab Ali,Diamler Vadlamuri et al.
Monica Gillie et al.
Background: Telehealth has evolved as a solution to COVID-19 isolation precautions and remote care with well-established health, socioeconomic, and practical benefits. However, there are many gaps in the current literatur...
Blood-Based Biomarkers for Alzheimer's Disease in Older Adults with Posttraumatic Stress Disorder [0.03%]
老年创伤后应激障碍患者中阿尔茨海默病的血液生物标志物研究
Nicolas Cimino,Min Suk Kang,Lawrence S Honig et al.
Nicolas Cimino et al.
Background: Posttraumatic stress disorder (PTSD) is associated with cognitive decline and risk for dementia, but the neuropathology involved is unclear. O...
Effects of a Personalized Music Intervention for Persons with Dementia and their Caregivers [0.03%]
针对痴呆症患者及其照料者的个性化音乐干预的效果研究
John Bufalini,Paul Eslinger,Erik Lehman et al.
John Bufalini et al.
Background: Given the challenges of developing disease-modifying treatments for Alzheimer's disease and related disorders, non-pharmacological interventions represent an increasingly promising approach in long-term care s...
Salivary Proteomics Identifies Transthyretin as a Biomarker of Early Dementia Conversion [0.03%]
唾液蛋白质组学鉴定出前蛋白转化蛋白为早期痴呆生物标志物
Ece Eldem,Aatmika Barve,Olivier Sallin et al.
Ece Eldem et al.
Background: Alzheimer's disease (AD) remains to date an incurable disease with a long asymptomatic phase. Early diagnosis in peripheral biofluids has emerged as key for identifying subjects at risk and developing therapeu...
Severe Gestational Low-Protein Intake Impacts Hippocampal Cellularity, Tau, and Amyloid-β Levels, and Memory Performance in Male Adult Offspring: An Alzheimer-Simile Disease Model? [0.03%]
妊娠期严重低蛋白摄入影响雄性子代成年海马细胞数量、tau和淀粉样蛋白-β水平及记忆表现：类似阿尔茨海默病模型？
Gabriel Boer Grigoletti-Lima,Marcelo Gustavo Lopes,Ana Tereza Barufi Franco et al.
Gabriel Boer Grigoletti-Lima et al.
Background: Maternal undernutrition has been associated with psychiatric and neurological disorders characterized by learning and memory impairment. Objec...
Robust Pharmacodynamic Effect of LY3202626, a Central Nervous System Penetrant, Low Dose BACE1 Inhibitor, in Humans and Nonclinical Species [0.03%]
LY3202626（一种能穿透中枢神经系统的低剂量β分泌酶1抑制剂）在人体和非临床物种中的稳健的药动学效应
Brian A Willis,Stephen L Lowe,Scott A Monk et al.
Brian A Willis et al.
Background: The development of beta-site amyloid-beta precursor protein cleaving enzyme (BACE) 1 inhibitors for the treatment of Alzheimer's disease requires optimization of inhibitor potency, selectivity, and brain penet...