Heightened Tameness and Accelerated Handling-Habituation in 3×Tg-AD Mice on a B6;129 Genetic Background [0.03%]
高育种背景下3倍体唐氏综合征小鼠温顺度增加及处理习惯化加速现象
Wen Hu,Chun-Ling Dai,Jiahui Niu et al.
Wen Hu et al.
Background: The triple transgenic mouse model of Alzheimer's disease (3×Tg-AD) has gained popularity in Alzheimer's research owing to the progressive development of both amyloid-β and tau pathologies in its brain. Prior...
EEG Abnormalities During Delirium as a Prodromal Feature of Dementia with Lewy Bodies: A Case Report [0.03%]
dementia with Lewy bodies患者在谵妄期间出现异常脑电图的病例报告
Claudia Carrarini,Matteo Alessandro De Rosa,Dario Calisi et al.
Claudia Carrarini et al.
Background: A 79-year-old woman was admitted to the Neurology Clinic of the University of Chieti-Pescara for a syncope. At admission, the occurrence of an acute stroke was ruled out. Her cognitive status was unimpaired. A...
Usability of the Virtual Supermarket Test for Older Adults with and without Cognitive Impairment [0.03%]
认知障碍老年人虚拟超市测试的适用性研究
Stelios Zygouris,Sofia Segkouli,Andreas Triantafyllidis et al.
Stelios Zygouris et al.
This study conducted a preliminary usability assessment of the Virtual Supermarket Test (VST), a serious game-based self-administered cognitive screening test for mild cognitive impairment (MCI). Twenty-four healthy older adults with subjec...
The Association Between Hearing Impairment, Vision Impairment, Dual Sensory Impairment, and Serious Cognitive Impairment: Findings from a Population-Based Study of 5.4 million Older Adults [0.03%]
一项基于540万老年人的全国性研究发现：听力障碍、视力障碍、感觉统合障碍与严重认知功能障碍之间的关系
Esme Fuller-Thomson,Aliya Nowaczynski,Andie MacNeil
Esme Fuller-Thomson
Background: Sensory impairments and cognitive impairment are increasing in scope due to the aging population. Objective: To investigate...
Association Between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in the Treatment of Depression in Patients with Alzheimer's Disease [0.03%]
多奈哌齐与胆碱前体石杉酸酯在阿尔茨海默病抑郁患者治疗中的关联性研究
Anna Carotenuto,Angiola Maria Fasanaro,Valentino Manzo et al.
Anna Carotenuto et al.
Background: Depressive symptoms are common in Alzheimer's disease (AD) patients and are associated with an increased functional decline. Selective serotonin reuptake inhibitor antidepressants showed a limited efficacy. ...
Explore the Mechanism of β-Asarone on Improving Cognitive Dysfunction in Rats with Diabetic Encephalopathy [0.03%]
β-asarone改善糖尿病脑病大鼠认知功能障碍的机制研究
Jingwen Cai,Ming Cai,Wenwen Xia et al.
Jingwen Cai et al.
Background: The number of people with diabetes is increasing, and many patients have significantly impaired cognitive function. For patients with diabetic encephalopathy (DE), simply lowering blood sugar does not improve ...
Reconsideration of Alzheimer's Disease Therapy from a Viewpoint of Amyloidogenic Evolvability [0.03%]
从淀粉样蛋白致病性的进化角度审视阿尔茨海默病的治疗措施
Gilbert Ho,Pei Chen Choo,Masaaki Waragai et al.
Gilbert Ho et al.
Presuming that Alzheimer's disease (AD) might represent an antagonistic pleiotropic phenomenon derived from the evolvability of multiple amyloidogenic proteins, targeting such proteins simultaneously could enhance therapeutic efficacy. Furt...
Neuroprotective Effects of Cholinesterase Inhibitors: Current Scenario in Therapies for Alzheimer's Disease and Future Perspectives [0.03%]
胆碱酯酶抑制剂的神经保护作用：阿尔茨海默病治疗现状及未来展望
Natália Chermont Dos Santos Moreira,Jéssica Ellen Barbosa de Freitas Lima,Marcelo Fiori Marchiori et al.
Natália Chermont Dos Santos Moreira et al.
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to the mild, moderate, and severe clinical stages of AD dementia. AD is conside...
Factors Influencing Change in Brain-Predicted Age Difference in a Cohort of Healthy Older Individuals [0.03%]
影响健康老年人脑部预测年龄差变化的因素
Jo Wrigglesworth,Ian H Harding,Phillip Ward et al.
Jo Wrigglesworth et al.
Background: There is considerable variability in the rate at which we age biologically, and the brain is particularly susceptible to the effects of aging. ...
Jonathan D&#x;Arcy Rudge
Jonathan D&#x;Arcy Rudge
This paper proposes a new hypothesis for Alzheimer's disease (AD)-the lipid invasion model. It argues that AD results from external influx of free fatty acids (FFAs) and lipid-rich lipoproteins into the brain, following disruption of the bl...