The Amyloid Cascade Hypothesis 2.0: On the Possibility of Once-in-a-Lifetime-Only Treatment for Prevention of Alzheimer's Disease and for Its Potential Cure at Symptomatic Stages [0.03%]
关于阿尔茨海默病预防及潜在治疗的阿米洛伊德瀑布假说2.0版本
Vladimir Volloch,Sophia Rits-Volloch
Vladimir Volloch
We posit that Alzheimer's disease (AD) is driven by amyloid-β (Aβ) generated in the amyloid-β protein precursor (AβPP) independent pathway activated by AβPP-derived Aβ accumulated intraneuronally in a life-long process. This interpret...
Patterns of Healthcare Use and Mortality After Alzheimer's Disease or Related Dementia Diagnosis Among Alaska Native Patients: Results of a Cluster Analysis in a Tribal Healthcare Setting [0.03%]
阿留申族医疗环境下老年痴呆或痴呆相关病人的医疗使用及死亡规律：部落医疗环境下的聚类分析结果
Jaedon P Avey,Krista R Schaefer,Carolyn J Noonan et al.
Jaedon P Avey et al.
Background: Alaska Native and American Indian (AN/AI) people represent a rapidly aging population with disproportionate burdens of Alzheimer's disease and related dementias (ADRD) risk factors. ...
Self- and Partner-Reported Subjective Memory Complaints: Association with Objective Cognitive Impairment and Risk of Decline [0.03%]
主观性记忆抱怨的自我报告和伴侣报告与客观性的认知障碍和恶化风险的关系
Leah Zuroff,Laura Em Wisse,Trevor Glenn et al.
Leah Zuroff et al.
Background: Episodic memory decline is a hallmark of Alzheimer's disease (AD). Subjective memory complaints (SMCs) may represent one of the earliest signs of impending cognitive decline. The degree to which self- or partn...
Evaluating the Impact of Community Gardening on Sense of Purpose for Persons Living with Dementia: A Cluster-Randomized Pilot Study [0.03%]
社区花园对痴呆症患者生活目的感的影响评价：分层随机对照试点研究
Abigail C Styck,Daniel R George
Abigail C Styck
Background: Gardening has been shown to have positive effects on persons living with dementia, but no studies have explored the effects of gardening on sense of purpose. ...
Mild Cognitive Disorder in Post-COVID-19 Syndrome: A Retrospective Cohort Study of 67,000 Primary Care Post-COVID Patients [0.03%]
后新冠综合征轻度认知障碍：一项针对67000名基层医疗后新冠患者的回顾性队列研究
Jens Bohlken,Kerstin Weber,Steffi Riedel Heller et al.
Jens Bohlken et al.
Background: Little is known about the impact of COVID-19 on mild cognitive disorder. Objective: The aim of this retrospective cohort st...
Building a Network of Adverse Outcome Pathways (AOPs) Incorporating the Tau-Driven AOP Toward Memory Loss (AOP429) [0.03%]
建立不良结局途径(AOP)网络(包括tau蛋白驱动的AOP造成记忆缺失(AOP429))
Maria Tsamou,Erwin L Roggen
Maria Tsamou
The adverse outcome pathway (AOP) concept was first proposed as a tool for chemical hazard assessment facilitating the regulatory decision-making in toxicology and was more recently recommended during the BioMed21 workshops as a tool for th...
Neural Mechanisms of Motor Dysfunction in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review [0.03%]
轻度认知障碍和阿尔茨海默病运动功能障碍的神经机制：系统性综述
Vincent Koppelmans,Benjamin Silvester,Kevin Duff
Vincent Koppelmans
Background: Despite the prevalence of motor symptoms in mild cognitive impairment (MCI) and Alzheimer's disease (AD), their underlying neural mechanisms have not been thoroughly studied. ...
Candesartan Effectively Preserves Cognition in Senescence Accelerated Mouse Prone 8 (SAMP8) mice [0.03%]
坎地沙坦有效改善老化加速系P8小鼠的学习记忆能力
Heba A Ahmed,Tauheed Ishrat
Heba A Ahmed
Background: Alzheimer's disease (AD) has become a worldwide crisis with no effective therapeutic options. The medications currently available for AD are only palliative; their effect is temporary, and they are associated ...
Emerging Pathophysiological Mechanisms Linking Diabetes Mellitus and Alzheimer's Disease: An Old Wine in a New Bottle [0.03%]
糖尿病与阿尔茨海默病的病理生理机制联系：旧瓶装新酒？
Vishvas N Patel,Mehul R Chorawala,Maitri B Shah et al.
Vishvas N Patel et al.
Type-2 diabetes mellitus (T2DM) is a chronic immuno-inflammatory and metabolic disease characterized by hyperglycemia and insulin resistance with corresponding hyperinsulinemia. On the other hand, Alzheimer's disease (AD) is a neurodegenera...
Under-Represented Populations Left Out of Alzheimer's Disease Treatment with Aducanumab: Commentary on Ethics [0.03%]
阿杜卡努单抗治疗阿尔茨海默病临床试验中未被充分代表的人群：伦理评论
Sanjana P Padala,Brandon C Yarns
Sanjana P Padala
Despite controversy about the efficacy and safety of aducanumab, the FDA's fast-tracking of this medicine is truly historic. However, structural problems leading to socioeconomic disparities and systemic racism in science, healthcare, and s...