Porphyromonas gingivalis Conditioned Medium Induces Amyloidogenic Processing of the Amyloid-β Protein Precursor upon in vitro Infection of SH-SY5Y Cells [0.03%]
牙龈卟啉单胞菌感染诱导神经细胞内淀粉样蛋白前体蛋白的淀粉样元加工反应
Shalini Kanagasingam,Christopher von Ruhland,Richard Welbury et al.
Shalini Kanagasingam et al.
Background: Cleavage of the amyloid-β protein precursor (AβPP) mediated by host secretase enzymes, releases several fragments including amyloid-β (Aβ40 and Aβ42). ...
Interaction Mechanism Between the HSV-1 Glycoprotein B and the Antimicrobial Peptide Amyloid-β [0.03%]
HSV-1糖蛋白B与抗菌肽淀粉样蛋白-β的作用机制
Karine Bourgade,Eric H Frost,Gilles Dupuis et al.
Karine Bourgade et al.
Background: Unravelling the mystery of Alzheimer's disease (AD) requires urgent resolution given the worldwide increase of the aging population. There is a growing concern that the current leading AD hypothesis, the amylo...
Improving Our Understanding of Driving Changes in Preclinical and Early Symptomatic Alzheimer's Disease: The Role of Naturalistic Driving Studies [0.03%]
提高我们对阿尔茨海默病前临床和早期有症状阶段变化的理解：自然驾驶研究的作用
Catherine M Roe
Catherine M Roe
Research on how preclinical and early symptomatic Alzheimer's disease (AD) impacts driving behavior is in its infancy, with several important research areas yet to be explored. This paper identifies research gaps and suggests priorities for...
Psychiatric and Psychosocial Characteristics of a Cohort of Spanish Individuals Attending Genetic Counseling Due to Risk for Genetically Conditioned Dementia [0.03%]
西班牙遗传咨询门诊高遗传性痴呆风险人群的心理和社会特征
Pau Sobregrau,Josep M Peri,Raquel Sánchez Del Valle et al.
Pau Sobregrau et al.
Background: Predictive genetic tests are presently effective over several medical conditions, increasing the demand among patients and healthy individuals. Considering the psychological burden suspected familial dementia ...
Metformin and Dementia Risk: A Systematic Review with Respect to Time Related Biases [0.03%]
二甲双胍与痴呆风险的系统评价：有关时间相关偏倚的文献分析
Jiahui Dai,Kayleen Deanna Ports,Maria M Corrada et al.
Jiahui Dai et al.
Background: When studying drug effects using observational data, time-related biases may exist and result in spurious associations. Numerous observational studies have investigated metformin and dementia risk, but have re...
Temporal Cortical Thickness and Cognitive Associations among Typical and Atypical Phenotypes of Alzheimer's Disease [0.03%]
阿尔茨海默病典型和非典型临床表型的皮层厚度及认知相关性
Alissa M Butts,Mary M Machulda,Peter Martin et al.
Alissa M Butts et al.
Background: The hippocampus and temporal lobe are atrophic in typical amnestic Alzheimer's disease (tAD) and are used as imaging biomarkers in treatment trials. However, a better understanding of how temporal structures d...
Detecting Primary Progressive Aphasia Atrophy Patterns: A Comparison of Visual Assessment and Quantitative Neuroimaging Techniques [0.03%]
原发进行性失语萎缩模式的检测：视觉评估和定量神经影像技术的比较
Stephanie Franczak,Jessica Pommy,Greta Minor et al.
Stephanie Franczak et al.
Background: There are now clinically available automated MRI analysis software programs that compare brain volumes of patients to a normative sample and provide z-score data for various brain regions. These programs have ...
What Biological Factors, Social Determinants, and Psychological and Behavioral Symptoms of Patients with Mild Alzheimer's Disease Correlate with Caregiver Estimations of Financial Capacity? Bringing Biases Against Older Women Into Focus [0.03%]
轻度阿尔茨海默病患者的相关生物因素、社会决定因素及心理和行为症状与护理人员对经济能力的评估有何关联？关注针对老年女性的偏见问题
Vaitsa Giannouli,Magda Tsolaki
Vaitsa Giannouli
This study examines the connection between biological factors, social determinants, and behavioral and psychological symptoms of dementia (BPSD) and the estimations of financial capacity made by caregivers of mild AD patients in Greece. Fin...
MoCA 7.1: Multicenter Validation of the First Italian Version of Montreal Cognitive Assessment [0.03%]
蒙特利尔认知评估（MoCA）意大利版的多中心验证：第一次迭代
Alessandro Pirani,Ziad Nasreddine,Francesca Neviani et al.
Alessandro Pirani et al.
Background: The early detection of neurocognitive disorders, especially when mild, is a key issue of health care systems including the Italian Dementia National Plan. The Mini-Mental State Examination (MMSE), i.e., the re...
Patient with Corticobasal Syndrome Showing Disease-Associated Biomarkers of Dementia with Lewy Bodies: A Treviso Dementia (TREDEM) Registry Case Report [0.03%]
皮质基底综合征患者表现出路易体痴呆相关生物标志物的特雷维索痴呆登记处病例报告
Maurizio Gallucci,Francesca Grassivaro,Chiara Da Ronch et al.
Maurizio Gallucci et al.
Background: An 82-year-old right-handed man, a retired teacher, reported the occurrence, three years earlier, of difficulties in moving his left arm and foot, tremor in his left hand, and gestures of the left upper limb t...