Hyperkinesia and early-onset dementia in a female with co-occurring PSEN1 and HTT mutations: A case report [0.03%]
携带PSEN1和HTT突变的女性出现肌张力障碍和早发性痴呆一例报告
Sean Lee,Firas Kaddouh
Sean Lee
A middle-aged female with family history of early-onset dementia presented with progressive amnesia, behavioral dysregulation, and myoclonus. Workup revealed pathogenic PSEN1 variant and intermediate HTT allele (30 CAG repeats). This case i...
Social interaction mitigates cognitive impairments and tau pathology in socially isolated aged mice [0.03%]
社交互动可减轻年老小鼠的社会隔离引起的认知障碍和Tau蛋白病病理变化
Jiayu Zeng,Zhenzhen Bao,Wanbing Huang et al.
Jiayu Zeng et al.
Background: Social isolation significantly heightens the risk of dementia among the elderly. Maintaining social engagement has been proposed as a potential strategy to attenuate age-related cognitive decline. ...
Red-flagging multimorbidity clusters for Alzheimer's disease risk using explainable machine learning: Evidence from a national emergency department sample [0.03%]
基于可解释机器学习的阿尔茨海默病风险红旗多发病簇证据：来自国家急诊科样本的证据
Tursun Alkam,Ebrahim Tarshizi,Andrew H Van Benschoten
Tursun Alkam
Background: Emergency-department (ED) visits capture diagnostic data that could flag patients at heightened risk for Alzheimer's disease (AD) long before cognitive symptoms are formally recognized. ...
Effects of sleep deprivation on cognition and synaptic associated proteins in rodents: A systematic review and meta-analysis [0.03%]
睡眠剥夺对啮齿动物认知和突触相关蛋白的影响：系统评价和meta分析
Hongqi Wang,Xin Mao,Siyu Liu et al.
Hongqi Wang et al.
Background: Sleep disorders are a significant risk factor for cognitive decline and Alzheimer's disease (AD). However, preclinical studies investigating the effects of sleep deprivation (SD) on cognition and synaptic prot...
Geospatial and temporal disparities in Alzheimer's disease deaths in Argentina [0.03%]
阿根廷阿尔茨海默病死亡的时空差异
Arturo L Morales,Lautaro D Andrade,Rubén Bronberg et al.
Arturo L Morales et al.
Background: Alzheimer's disease (AD) and other dementias are currently among the leading causes of morbidity and mortality worldwide. Objective: ...
Association between self-reported sensory impairments and low cognitive performance in older adults: A cross-sectional study based on National Health and Nutrition Examination Survey (NHANES) [0.03%]
基于全国健康与营养调查的横断面研究：老年人感知能力障碍与认知表现之间的关联
Lu He,Yuansheng Rao,Jianhong Wang et al.
Lu He et al.
Background: Early identification of risk factors is vital for the control of cognitive degenerative diseases, and sensory impairments could be potential candidate indicators. ...
Tar DNA binding protein 43, a proteinopathy with preference for olfactory structures in COVID-19 subjects [0.03%]
Covid-19患者中TARDNA结合蛋白43对嗅觉结构的优先作用
Sylwia Libard,Irina Alafuzoff
Sylwia Libard
Background: Olfactory impairment (OI) is an early symptom of neurodegenerative diseases (ND) and COVID-19 infection. Proteinopathies associated with ND include amyloid-β (Aβ), hyperphosphorylated τ (HPτ), α-synuclein...
Vitreous STMN2 levels reflect TDP-43-associated neurodegeneration in postmortem eyes and brains [0.03%]
玻璃体STMN2水平反映死后眼睛和与TDP-43相关的脑神经退行性病变
Surya V Pulukuri,Elizabeth E Spurlock,Fatima Tuz-Zahra et al.
Surya V Pulukuri et al.
Stathmin-2 (STMN2) levels decline in brains with transactive response DNA binding protein-43 (TDP-43) inclusions. TDP-43-related changes could extend to ocular structures, although vitreous STMN2 levels remain uncharacterized. This explorat...
Cognitive reserve as a predictor of cognitive decline, but not age of diagnosis in patients with possible young-onset Alzheimer's disease: An underexplored population [0.03%]
认知储备作为预测可能的年轻发病阿尔茨海默病患者认知下降而非诊断年龄的指标：一个被忽视的人群
Anat Marmor,Zeev Meiner,Shlomzion Kahana Merhavi et al.
Anat Marmor et al.
Background: The cognitive reserve (CR) theory aims to explain the disparity often observed between brain damage and its clinical manifestation. Objective:...
Comprehensive descriptive analysis of large Alzheimer's disease patient cohorts [0.03%]
阿尔茨海默病患者大队列的全面描述性分析
Ehsan Yaghmaei,Attallah Dillard,Mohammadreza Rezaei et al.
Ehsan Yaghmaei et al.
Background: Precise estimates of the prevalence of Alzheimer's disease (AD), the distribution of demographic characteristics, comorbidities, treatment plans, insurance types, cost of treatment and survival probabilities a...