Qualitative insights into participant and care partner perspectives on research-based Alzheimer's disease biomarker testing and disclosure [0.03%]
阿尔茨海默病研究型生物标志物检测与披露的参与者及护理者视角 qualitative 研究见解
Annalise Rahman-Filipiak,Mary Lesniak,Alicia Burgei et al.
Annalise Rahman-Filipiak et al.
Background: There is strong desire for the return of individual results, including biomarker testing, among participants in Alzheimer's disease and related dementias (ADRD) studies. However, it is not known whether partic...
P-tau217 and %p-tau217 exhibited superior diagnostic accuracy over other blood biomarkers in the initial assessment of individuals being diagnosed with mild cognitive impairment and Alzheimer's disease dementia [0.03%]
P-tau217 和 %p-tau217 在轻度认知障碍和阿尔茨海默病痴呆初始诊断中的鉴别价值优于其他血液生物标志物
Qiongqiong Qiu,Weiqiang Qian,Wanying Zhao et al.
Qiongqiong Qiu et al.
Background: High-performance blood tests may improve diagnostic accuracy and support personalized treatment for Alzheimer's disease (AD), but validation at the time of initial clinical diagnosis remains limited. ...
Studies on copper (II) interaction with the (CCG)12 repeats sequence: An insight into genomic instability in neurodegeneration [0.03%]
铜(Ⅱ)与(CCG)₁₂重复序列相互作用的研究——神经退行性疾病中基因组不稳定性的启示
Lakshmi Sowmya Emani,Jayanth K Rao,Jagadeesha Kumar Dasappa et al.
Lakshmi Sowmya Emani et al.
Background: Studies indicate that a comprehensive understanding of the mechanisms underlying neurodegeneration in Alzheimer's disease, Parkinson's disease, and related disorders is still not clearly understood. Fragile X-...
Microbiome alterations in Alzheimer's disease: A systematic review of current evidence and global perspectives [0.03%]
阿尔茨海默病中的微生物组变化：当前证据和全球观点的系统回顾
Tolutope Adebimpe Oso,Olalekan John Okesanya,Uthman Okikiola Adebayo et al.
Tolutope Adebimpe Oso et al.
Background: Growing evidence implicates the gut-brain axis in Alzheimer's disease (AD), with gut microbiome dysbiosis proposed to modulate neuroinflammation, amyloid pathology, and cognitive decline. ...
Network meta-analysis of the efficacy of nine drugs for cognitive function in patients with Alzheimer's disease [0.03%]
九种药物治疗阿尔茨海默病患者认知功能的网络meta分析研究
Shanshan Huang,Yunyun Guo
Shanshan Huang
Background: Alzheimer's disease (AD) remains a global challenge, and the comparative cognitive efficacy of emerging pharmacotherapies is still unclear. Ob...
Exploring BSCL2 and associated genes in Alzheimer's disease by integrative analysis of bioinformatics, sn-RNAseq and machine learning approach [0.03%]
基于生物信息学、snRNA测序和机器学习的阿尔茨海默病中BSCL2及其相关基因的功能研究
Xiaoqiong An,Yijia Wang,Manni Cao et al.
Xiaoqiong An et al.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by significant cognitive decline and memory impairment. This condition imposes a considerable economic burden on healthcare sy...
The causal association between the new gut microbiota and Alzheimer's disease: A Mendelian randomization study [0.03%]
新型肠道微生物组与阿尔茨海默病的因果关系：一项孟德尔随机化研究
Fengwen Lin,Xueqiang Yang,Xuelong Xie et al.
Fengwen Lin et al.
Background: There is a need for more studies to validate the role of gut microbiota in Alzheimer's disease (AD). Objective: This study ...
From routine periodontal therapy to Alzheimer's disease early detection: A scoping review [0.03%]
从牙周病常规治疗到阿尔茨海默病的早期检测：综述性评论
Qiang Zhang,Lina Almanie,Yi Ouyang et al.
Qiang Zhang et al.
An epidemiological association has been observed between periodontitis and Alzheimer's disease (AD); however, salivary and blood assays often show low specificity. Periodontal tissues and fluids, which are routinely removed and discarded du...
Distinct brain volume changes associated with the head-turning sign and Neucop-Q response patterns in Alzheimer's disease [0.03%]
阿尔茨海默病患者头部转动体征和NeuCOP-Q反应模式相关的不同脑体积变化
Memi Watanabe,Shogyoku Bun,Atsushi Shimizu et al.
Memi Watanabe et al.
Background: The "head-turning sign" (HTS) and Neurocognitive Questionnaire (Neucop-Q) capture toritsukuroi (saving appearance) behaviors commonly observed in Alzheimer's disease (AD). Neucop-Q is a brief screening questio...
Large-scale APP duplication in early-onset Alzheimer's disease without cerebral amyloid angiopathy: A case report [0.03%]
早发性阿尔茨海默病伴大脑无淀粉样血管病的APP基因多倍体一例报告
Sho Shimohama,Shumpei Azami,Munenori Oyama et al.
Sho Shimohama et al.
We present the case of a patient who began experiencing cognitive decline in her 30 s and was diagnosed with duplication of the amyloid precursor protein (Dup-APP) associated early-onset Alzheimer's disease (EOAD). The diagnosis was support...