Social determinants of health, genetic biomarkers, and cognitive function in Chinese older adults with subjective cognitive decline and mild cognitive impairment: A cross-sectional analysis [0.03%]
社会决定因素、遗传生物标志物及主观认知下降和轻度认知障碍中国老年人的认知功能：一项横断面分析
Chun-Xu Shi,Jia-Huan Li,Jin Liu et al.
Chun-Xu Shi et al.
Background: Social isolation (SI) is an established risk factor for Alzheimer's disease (AD) and cognitive decline. However, its stage-specific effects across the AD continuum, particularly at subjective cognitive decline...
Amy Clements-Cortés,Anna Bryan,Sarah Faber et al.
Amy Clements-Cortés et al.
Background: Cognitive decline and dementia can have a major impact on individuals, families, societies and economies. While there are currently no cures for Alzheimer's disease and related dementias, and available treatme...
TARDBP gene mutation in a Chinese family with frontotemporal dementia: A case report and literature review [0.03%]
TARDBP基因突变在中国以行为异常为首发症状的额颞叶痴呆家系中的发现及文献复习
Xue Zhao,Liyong Wu,Pan Li
Xue Zhao
Background: Mutations in the transactive response DNA binding protein (TARDBP) have never been reported in the population of familial frontotemporal dementia (FTD) in Chinese mainland. ...
Impact of anticoagulation on cognitive decline and clinical outcomes in patients with atrial fibrillation and dementia: A retrospective cohort study [0.03%]
抗凝对心房颤动伴痴呆患者认知功能下降及临床结局的影响：回顾性队列研究
Yun Du,Weng-Chio Tam,Man-Fong Chu et al.
Yun Du et al.
Background: Atrial fibrillation (AF) and dementia frequently coexist in older adults, yet the impact of anticoagulation on cognitive and clinical outcomes in this population remains uncertain. ...
The relationship between marital status and cognitive function in Chinese older adults: The mediating role of depressive symptoms [0.03%]
中国老年人婚姻状况与认知功能的关系：抑郁症状的中介作用
Guanhua Zong,Ran Li,Yuhang Jiang et al.
Guanhua Zong et al.
Background: Emerging research indicates a possible link between marital status and cognitive performance among elderly individuals, yet limited investigations have explored the potential mediating effects of depressive sy...
Association between the coronavirus disease pandemic and antipsychotic drug prescriptions among patients with dementia [0.03%]
新冠肺炎流行与痴呆患者抗精神病药物处方之间的关系
Kyungduk Hurh,Hyunkyu Kim,Eun-Cheol Park
Kyungduk Hurh
Background: Antipsychotics are frequently prescribed off-label to manage behavioral and psychological symptoms of dementia but pose safety risks in older adults, including a 1.5-2.0-fold increased risk of mortality. The c...
A novel PSEN1 (p.Gln223Leu) variant associated with spastic paraparesis and early-onset Alzheimer's disease [0.03%]
与共济失调和早发性阿尔茨海默病相关的新PSEN1（p.Gln223Leu）变异体
Hyuk-Je Lee,Hansol Im,Bora Yoon et al.
Hyuk-Je Lee et al.
We report a novel PSEN1 likely pathogenic variant associated with spastic paraparesis (SP) preceding cognitive decline. A 41-year-old man with a two-year history of SP followed by cognitive impairment one year later, was found to carry a he...
Challenges in community-based recruitment of Alzheimer's disease cases: Experience of the monitoring drug efficacy through multi-omics research initiative in Alzheimer's disease (MEMORI-AD) study [0.03%]
阿尔茨海默病社区招募的挑战：阿尔茨海默病监测药物疗效的多组学研究（MEMORI-AD）的经验
Fresthel Monica M Climacosa,Eric David B Ornos,Erwin Rommel S Diwa et al.
Fresthel Monica M Climacosa et al.
Background: The Monitoring drug Efficacy through Multi-Omics Research Initiative in Alzheimer's Disease (MEMORI-AD) study aims to characterize drug response to donepezil and memantine in a Filipino cohort with late-onset ...
Applications and implicit assumptions in dementia risk scores: A scoping review of the LIBRA score [0.03%]
老年痴呆症风险评分的应用及潜在假设——对LIBRA评分的综述性研究
Wouter Mr Kant,Wieske K de Swart,Jim M Smit et al.
Wouter Mr Kant et al.
Dementia risk scores are commonly used tools to estimate the risk of developing Alzheimer's disease and dementia. We lack an overview of what risk scores are used for, what is claimed they ought to be used for, and whether they are suitable...
Validation of Russian versions of the DKAS, DAS, and CODE scales: Measuring dementia knowledge, attitudes, and care confidence [0.03%]
DKAS、DAS和CODE量表的俄文版验证：测量痴呆知识、态度及照护自信度
Sergey Zakharov,Aaron Schröter,Birgit Teichmann
Sergey Zakharov
Background: Dementia is one of the main public health challenges worldwide. To evaluate awareness programs, it is necessary to use validated scales, such as the Dementia Knowledge Assessment Scale (DKAS), the Dementia Att...