Long-Term Effects of the Multicomponent Program BrainProtect® on Cognitive Function: One-Year Follow-Up in Healthy Adults [0.03%]
多组分脑保护程序对健康成年人认知功能的长期影响：一年随访研究
Michelle Celine Kunkler,Julia Maria Falkenreck,Anja Ophey et al.
Michelle Celine Kunkler et al.
Background: Age-related neuronal changes impact cognitive integrity, which is a major contributor to health and quality of life. The best strategy to prevent cognitive decline and Alzheimer's disease is still debated. ...
Association of Cerebral Hypoperfusion and Poor Collaterals with Cognitive Impairment in Patients with Severe Vertebrobasilar Artery Stenosis [0.03%]
严重椎基底动脉狭窄患者脑低灌注及较差侧支循环与认知障碍的关系
Weiyi Zhang,Weilun Fu,Yumei Zhang
Weiyi Zhang
Background: Effect of stenosis of vertebrobasilar artery (VBA) on cognitive function is elusive. Objective: To investigate association ...
Exploring Causal Relationships Between Gut Microbiota and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study [0.03%]
探索肠道菌群与阿尔茨海默病的因果关系：一项双向孟德尔随机化研究
Anqi Chen,Yuquan Wang,Yue-Qing Hu
Anqi Chen
Background: Many observational studies have investigated the link between the gut microbiota and Alzheimer's disease (AD), but the causality remains uncertain. ...
An Investigation of the Inflammatory Landscape in the Brain and Bone Marrow of the APP/PS1 Mouse [0.03%]
APP/PS1鼠脑和骨髓的炎症谱系研究
Kishore Chittimalli,Stephen Adkins,Sanjay Arora et al.
Kishore Chittimalli et al.
Background: The APP/PS1 mouse model recapitulates pathology of human Alzheimer's disease (AD). While amyloid-β peptide deposition and neurodegeneration are features of AD, the pathology may involve inflammation and impai...
Coexisting Logopenic Variant of Primary Progressive Aphasia with Amyloid Pathology and Early Parkinsonism [0.03%]
伴有淀粉样蛋白病理改变的原发性进行性失语联合早期帕金森病共病病例
Martina Caccamo,Daniele Urso,Alfredo Gabriele Nanni et al.
Martina Caccamo et al.
The presence of parkinsonism features in primary progressive aphasia (PPA) is a subject of ongoing research. These features are usually more pronounced in the advanced stages of the disease, particularly in the non-fluent/agrammatic subtype...
Clinical Heterogeneity in Alzheimer's Disease: A Possible New Amnesic Phenotype [0.03%]
阿尔茨海默病的临床异质性：可能存在的新的遗忘症表型
Carlo Abbate,Alessia Gallucci,Pietro Davide Trimarchi et al.
Carlo Abbate et al.
We rediscovered a phenotype of AD known in the early 1900s as presbyophrenia, but then forgotten, and renamed as confabulation-misidentification phenotype. The phenotype includes diencephalic amnesia whose prototype is Korsakoff syndrome. T...
Porphyromonas gingivalis LPS and Actinomyces naeslundii Conditioned Medium Enhance the Release of a Low Molecular Weight, Transcriptionally Active, Fragment of Glycogen Synthase-3 Kinase in IMR-32 Cell Line [0.03%]
牙龈卟啉单胞菌LPS和奈氏放线菌培养上清液增强IMR-32细胞低分子量转录活性的糖原合酶激酶片段的释放
Sim K Singhrao,Claudia Consoli,Sarah R Dennison et al.
Sim K Singhrao et al.
Background: Glycogen synthase-3 kinase (GSK3) is one of the major contributors of tau hyperphosphorylation linked to neurofibrillary tangles in Alzheimer's disease (AD). ...
Causal Association Between Type 2 Diabetes Mellitus and Alzheimer's Disease: A Two-Sample Mendelian Randomization Study [0.03%]
二型糖尿病与阿尔茨海默病的因果关系：两样本孟德尔随机化研究
Cong Li,Haifeng Qian,Lina Feng et al.
Cong Li et al.
Background: There is now increasing evidence that type 2 diabetes mellitus (T2DM) is associated with Alzheimer's disease (AD). However, it is unclear whether the two are causally related. ...
Language Markers of Dementia and Their Role in Early Diagnosis of Alzheimer's Disease: Exploring Grammatical and Syntactic Competence via Sentence Repetition [0.03%]
语言标志与痴呆症及其在阿尔茨海默病早期诊断中的作用：通过句子重复探索语法和句法能力
Maria Kaltsa,Anthoula Tsolaki,Ioulietta Lazarou et al.
Maria Kaltsa et al.
Background: Earlier research focuses primarily on the cognitive changes due to Alzheimer's disease (AD); however, little is known with regard to changes in language competence across the lifespan. ...
The Effect of Computerized Cognitive Training, with and without Exercise, on Cortical Volume and Thickness and Its Association with Gait Speed in Older Adults: A Secondary Analysis of a Randomized Controlled Trial [0.03%]
计算机认知训练，联合或不联合运动对老年人脑皮层体积和厚度的影响及其与步速的关系：一项随机对照试验的二次分析结果
Ryan G Stein,Lisanne F Ten Brinke,Nárlon C Boa Sorte Silva et al.
Ryan G Stein et al.
Background: Slower walking is associated with changes in cortical volume and thickness. Computerized cognitive training (CCT) and exercise improve cortical volume and thickness and thus, may promote gait speed. Slowing of...