Agentic artificial intelligence in cognitive screening: A translational roadmap for dementia care [0.03%]
具有代理性的人工智能在认知筛查中的应用：痴呆症护理的转化路线图
Kevin Mekulu,Faisal Aqlan,Hui Yang
Kevin Mekulu
Conventional dementia screening tools, whether paper tests or static artificial intelligence (AI) models, capture only a snapshot of cognition and need to be adminstered periodically. Yet decline is dynamic, shaped by environment, comorbidi...
Fosgonimeton in mild-to-moderate Alzheimer's disease [0.03%]
弗格尼梅通治疗中至轻度阿尔茨海默病的效果及安全性：2 期双盲随机安慰剂对照临床试验
Anton P Porsteinsson,Marwan Sabbagh,Pierre N Tariot et al.
Anton P Porsteinsson et al.
Background: Fosgonimeton, a small-molecule positive modulator of the neurotrophic hepatocyte growth factor (HGF) system, was studied in participants with Alzheimer's disease (AD). ...
Driving into diagnosis: Leveraging high-resolution telematics and sensorimotor profiling to identify preclinical Alzheimer's disease [0.03%]
驶向诊断：利用高分辨率车联网和感觉运动特征谱系识别临床前阿尔茨海默病
Behdad Parhizi,Ramana Kolady,Mia T Vogel et al.
Behdad Parhizi et al.
Background: Early detection of preclinical Alzheimer's disease (AD) could expand preventative care. Current biomarkers are costly, invasive, or lack generalizability. Driving and sensorimotor performance may reveal prodro...
Subjective cognitive decline among older U.S. military veterans: A 3-year, nationally representative, longitudinal study [0.03%]
美国老年退伍军人认知功能下降的纵向全国代表性研究
Michael F Georgescu,Ian C Fischer,May A Beydoun et al.
Michael F Georgescu et al.
Subjective cognitive decline (SCD) is an early risk marker for dementia. This study examined the 3-year incidence and predictors of SCD using the Medical Outcomes Study Cognitive Functioning Scale-Revised in a national sample of 1858 U.S. m...
Daily life experiences of an older woman with Alzheimer's disease residing alone as recorded in her diaries [0.03%]
阿尔茨海默病独居老年女性的日常生活体验——日记里的故事
Saori Hirano,Lu Zhou,Motoshi Ouchi et al.
Saori Hirano et al.
Background: In Japan, the aging population is rapidly increasing, with more older persons residing alone. Among them, individuals with dementia face unique challenges in maintaining daily life and self-identity. ...
Metabolic factors, gut microbiota, and cognitive performance: Mendelian randomization analysis [0.03%]
代谢因素、肠道微生物群和认知表现：孟德尔随机化分析
Erhan Yu,Yi Zhang,Jiahui Chen et al.
Erhan Yu et al.
Background: The associations between several metabolic factors, gut microbiota (GM), and cognitive performance have not been clearly identified. This study investigates their associations and GM's mediating effects. ...
Psychometric evaluation of the Alzheimer's Disease Knowledge Scale in Ecuadorian university students [0.03%]
艾尔伯特病知识量表在厄瓜多尔大学生中的心理测量学评价研究
José Alejandro Valdevila Figueira,Andrés Ramírez,Xavier Rodrigo Yambay-Bautista et al.
José Alejandro Valdevila Figueira et al.
Background: Alzheimer's disease (AD) is the leading cause of dementia worldwide, with rising prevalence, high costs, and significant impact in Ecuador. Awareness and validated tools like the Alzheimer's Disease Knowledge ...
Amyloid marker levels and the risk of developing cerebral small vessel disease: A Mendelian randomization study [0.03%]
淀粉样标志物水平与脑小血管病发病风险之间的关系：一项孟德尔随机化研究
Zhuoya Wang,Kailin Xia,Xin Huang et al.
Zhuoya Wang et al.
Background: Previous observational studies have suggested a potential association between amyloid marker levels and the risk of developing cerebral small vessel disease (CSVD), but this relationship remains incompletely u...
Defining healthy longevity and dementia prevention campaigns have been tied to the ability to work [0.03%]
界定健康长寿和痴呆预防活动与工作能力息息相关
Bilal Irfan,Roberto Sirvent,Hana Abbasian et al.
Bilal Irfan et al.
Contemporary dementia-prevention campaigns inherit a century-old coupling of health with economic productivity. By framing "healthy longevity" as the capacity to sustain waged labor, they cast risk reduction as a personal duty to insure fut...
Clarifying blood-based brain-derived neurotrophic factor measurement in Alzheimer's disease research: A call for pre-analytic standardization [0.03%]
阿尔茨海默病研究中基于血液的脑源性神经营养因子测量的规范化前标准迫在眉睫：呼唤明确化和标准化
Ted Ks Ng
Ted Ks Ng
The study by Kueck et al. rigorously addresses the complex pre-analytical and biological confounds underlying blood-based brain-derived neurotrophic factor (BDNF) measurement in Alzheimer's disease (AD) research. By directly comparing plate...