A historic case of relapsing-remitting Alzheimer's disease in an adolescent attributed to scarlet fever [0.03%]
与猩红热有关的青少年复发缓解型阿尔茨海默病的历史病例报道
Richard Lathe,Brian Balin
Richard Lathe
We draw attention to a historic case of a boy who suffered from scarlet fever (typically caused by the bacterium Streptococcus pyogenes) at age 7 years and went on to develop the symptoms of Alzheimer's disease (AD). His physicians believed...
Erratum to "Identifying shared diagnostic genes and mechanisms in vascular dementia and Alzheimer's disease via bioinformatics and machine learning" [0.03%]
《通过生物信息学和机器学习识别血管性痴呆和阿尔茨海默病的共有的诊断基因和机制》一文的勘误
[This corrects the article DOI: 10.1177/25424823241289804.]. © The Author(s) 2025.
Lower expression of BIN1's neuronal isoform in vulnerable excitatory neurons increases risk in Alzheimer's disease [0.03%]
神经元BIN1异构体在易受攻击的兴奋性神经元中的低表达会增加患阿尔茨海默病的风险
Rajesh Ranganathan,Siwen Li,Georgy Sapozhnikov et al.
Rajesh Ranganathan et al.
Background: Neurons in Alzheimer's disease (AD) experience elevated DNA damage, with DNA repair sites enriched at enhancer regions of genes essential for neuronal survival. Excitatory neurons in the cortical superficial l...
How follow-up period in prospective cohort studies affects the relationship between baseline fish consumption and risk of Alzheimer's disease and dementia [0.03%]
前瞻性队列研究中随访期对基线鱼类消费与阿尔茨海默病和痴呆风险关系的影响
William B Grant
William B Grant
Background: Diet plays an important role in the risk of Alzheimer's disease (AD) and dementia. Adherence to the Mediterranean diet is regarded as one way to reduce risk. Fish is a component of the Mediterranean diet. Part...
Yuhang Chen,Junlin Diao,Xuezhuang Ren et al.
Yuhang Chen et al.
Background: Cognitive impairment patients are prone to malnutrition, which further promotes cognitive decline. Cognitive impairment patients are unable to accurately answer subjective questions in the nutrition screening ...
The causal role of lipids in dementia: A Mendelian randomization study [0.03%]
脂质在痴呆症中的因果作用：一项孟德尔随机化研究
Boyang Su,Zhengqing He,Li Mao et al.
Boyang Su et al.
Background: Increasing evidence suggests that abnormal lipid metabolism is one of the pathogeneses of dementia. It is necessary to reveal the relationship between lipids and dementia. ...
Heat shock protein 70 in Alzheimer's disease and other dementias: A possible alternative therapeutic [0.03%]
阿尔茨海默病及其他痴呆症中的热休克蛋白70：一种可能的替代疗法
Antonio Valle-Medina,Claudia Camelia Calzada-Mendoza,María Esther Ocharan-Hernández et al.
Antonio Valle-Medina et al.
Alzheimer's disease (AD) is considered a global health issue with a high social burden due to the level of disability it causes in those who suffer from it. In the absence of a therapeutic alternative for this disease, we will follow one of...
Sentiment analysis of social media responses to the approval of lecanemab for the treatment of Alzheimer's disease in Japan [0.03%]
对日本批准lecanemab治疗阿尔茨海默病的社交媒体反应的情感分析
Kenichiro Sato,Yoshiki Niimi,Ryoko Ihara et al.
Kenichiro Sato et al.
Lecanemab, an anti-amyloid therapy for early Alzheimer's disease, received approval by the FDA and Japan in 2023. Public response on social media was scrutinized, aiming to obtain insights into communication and treatment development. For 4...
Exploring causal relationship of traumatic brain injury and comorbidities: A Mendelian randomization study [0.03%]
探索创伤性脑损伤和共病性的因果关系：孟德尔随机化研究
Xiaohang Zhang,Wenze Wu,Yaqing Mao et al.
Xiaohang Zhang et al.
Background: Previous observational studies demonstrated a link existed between traumatic brain injury (TBI) and cerebral disease and multisystem complications, such as dementia, pneumonia, and gastrointestinal disease, bu...
Intravenous thrombolysis therapy and dementia risk in acute ischemic stroke patients: A retrospective cohort study in Taiwan [0.03%]
静脉溶栓治疗与急性缺血性卒中患者痴呆风险的关系：一项来自台湾的回顾性队列研究
Yan-Siang Huang,Te-Jung Kung,Yi-Fang Chuang
Yan-Siang Huang
Background: Intravenous thrombolysis (IVT) is the standard treatment for acute ischemic stroke (AIS) to improve functional outcomes. Furthermore, AIS is an important risk factor for dementia. Limited evidence has shown th...