Sociodemographic and clinical profile from the Brazilian very old 90+ study (BRAVO-90+) [0.03%]
巴西老年人口特征和临床状况的90+研究(BRAVO-90+)
Aline Maria Macagnan Ciciliati,Renata Elaine Paraizo Leite,Lea T Grinberg et al.
Aline Maria Macagnan Ciciliati et al.
Background: Cognitive impairment and disability are frequent among the oldest-old population, particularly in low- and middle-income countries (LMIC), where this population is rapidly increasing. However, studies on peopl...
Potential cure of Alzheimer's disease by reducing the level of Cdk5 using two drugs, each with a different modus operandi [0.03%]
利用两种具有不同作用机制的药物降低Cdk5水平治疗阿尔茨海默病的潜在方法
Jeffrey Fessel
Jeffrey Fessel
There is need to understand the direct cause and, therefore, the appropriate treatment, of Alzheimer's disease (AD). A Google search was used to discern a) the primary cause of AD, and b) its treatment. Activation of Cdk5 is the primary cau...
Utility of the Rowland Universal Dementia Assessment Scale and INECO Frontal Screening for differentiating dementia subtypes between Alzheimer's disease and Parkinson's disease dementia [0.03%]
用于区分阿尔茨海默病和帕金森病性痴呆亚型的Rowland通用失智症评估量表和INECO额叶筛选表的作用
Gregory Brown,Diego Bustamante-Paytan,María Fe Albujar Pereira et al.
Gregory Brown et al.
Background: Time to dementia diagnosis is a major barrier to effective care, particularly in resource-limited settings such as Latin America. Barriers to timely dementia diagnosis include the lack of access to comprehensi...
Cerebrospinal fluid Visinin-like protein-1 was associated with the relationship of body mass index with Alzheimer's disease pathology and cognition in non-demented elderly [0.03%]
脑脊液中的视网膜毒性蛋白-1与非痴呆老年人中体重指数与阿尔茨海默病病理和认知之间的关系有关
Yayu Wang,Siqi Yu,Man Zhang et al.
Yayu Wang et al.
Background: The relationship and mechanisms between body mass index (BMI) and cognition are complex and inconclusive. Additionally, the role of neuronal calcium dysfunction, reflected by cerebrospinal fluid (CSF) Visinin-...
A novel SORL1 mutation in a pedigree affected by early-onset Alzheimer's disease [0.03%]
早发性阿尔茨海默病家系中SORL1的新突变
Veronica Redaelli,Martina Ricci,Angelo Del Sole et al.
Veronica Redaelli et al.
Familial cases of Alzheimer's disease (AD) with autosomal dominant transmission and early onset have a prevalence around 1%. Since only a small fraction of them has a monogenic inheritance due to APP, PSEN1, and PSEN2 genes, genetic studies...
Identifying Alzheimer's disease genes in apolipoprotein E-/- mice brains with confirmed Porphyromonas gingivalis entry [0.03%]
在确认有牙龈卟啉单胞菌入侵的载脂蛋白E基因敲除小鼠大脑中鉴定阿尔茨海默病基因
Sim K Singhrao,Claudia Consoli
Sim K Singhrao
Background: The apolipoprotein E allele ε4 is the most well-known predisposing genetic risk factor for Alzheimer's disease (AD). Objective: ...
Cerebrospinal fluid cytokine levels affect electroencephalographic activity in Alzheimer's disease [0.03%]
脑脊液细胞因子水平影响阿尔茨海默病的脑电活动
Matilde Bruno,Chiara Giuseppina Bonomi,Alessandro Castelli et al.
Matilde Bruno et al.
To investigate the role of neuroinflammation as mediator of amyloid-β-induced cortical activity changes in Alzheimer's disease (AD), we examined the relationship between cerebrospinal fluid (CSF) inflammatory cytokines (IL-1β, IL-2, IL-4,...
The short-term impacts of COVID-2019 on depressive symptoms and cognitive decline: A community-based cohort study [0.03%]
COVID-2019对抑郁症状和认知下降的短期影响：基于社区队列研究
Mengmeng Ji,Darui Gao,Jie Liang et al.
Mengmeng Ji et al.
Background: Neurological and psychological sequelae may persist after the infection of coronavirus disease 2019 (COVID-19). Depression and cognitive decline could increase the risk of Alzheimer's disease. ...
Brain morphology mediating the effects of common genetic risk variants on Alzheimer's disease [0.03%]
介导常见遗传风险变异对阿尔茨海默病影响的脑形态特征
Esmee M Breddels,Yelyzaveta Snihirova,Ehsan Pishva et al.
Esmee M Breddels et al.
Background: Late-onset Alzheimer's disease (LOAD) has been associated with alterations in the morphology of multiple brain structures, and it is likely that disease mechanisms differ between brain regions. Coupling geneti...
Demographic predictors of cognitive performance in participants of a local substance abuse recovery program [0.03%]
当地毒品滥用康复计划参与者认知表现的人口学预测因素
Ge Wang,Huijun Yi,Daniel Y Li et al.
Ge Wang et al.
Background: Cognitive impairments have been reported among disadvantaged populations. Objective: We aimed to ascertain how demographic ...