A pathway-informed disease-related gene identification approach and its application to screen novel risk genes for Alzheimer's disease [0.03%]
一种用于识别与疾病相关的基因的基于通路的方法及其在筛选新的阿尔茨海默氏症风险基因中的应用
Xin Yuan,Lihui Gao,Hao Wang et al.
Xin Yuan et al.
Background: Alzheimer's disease (AD) is a severe neurodegenerative disorder, yet its molecular mechanisms remain incompletely understood. It is known that the joint action of a number of genetic and other factors is invol...
The diagnostic accuracy of CTseg segmentation software for dementia in a New Zealand memory service [0.03%]
一种痴呆诊断CT图像分割软件的准确性研究：来自新西兰记忆诊所的研究
Mukish Yelanchezian,Cristian Gonzalez-Prieto,Bede Oulaghan et al.
Mukish Yelanchezian et al.
This study examines the accuracy of CTseg segmentation software to diagnose Alzheimer's disease dementia and other dementias using routine CT scans from a New Zealand memory service. Analyzing 168 scans (89 with dementia and 79 without deme...
The association of dietary protein intake in three meals and cognitive performance among people over sixty years old [0.03%]
不同年龄人群三餐蛋白质摄入与认知功能的关系研究
Fengru Niu,Yifan Ma,Xiaodi Yuan et al.
Fengru Niu et al.
Background: Cognitive dysfunction caused by aging is becoming increasingly significant, and despite increasing global attention to the prevention and treatment of cognitive impairment, effective treatment methods remain e...
Exploring the link between GLP-1 receptor agonists and dementia: A comprehensive review [0.03%]
GLP-1受体激动剂与痴呆症关联的探索：全面综述
Mallika Chuansangeam,Pawit Phadungsaksawasdi,Hyo Jin Park et al.
Mallika Chuansangeam et al.
Type 2 diabetes mellitus (T2DM) and insulin resistance are associated with an increased risk of cognitive decline and dementia, including Alzheimer's disease (AD). Glucagon-like peptide-1 receptor agonists (GLP-1RAs), originally developed f...
DNA methylation in peripheral blood leukocytes in late onset Alzheimer's disease [0.03%]
外周血白细胞DNA甲基化与晚发性阿尔茨海默病的关系研究
Tatiana Chacón,Hernán G Hernández
Tatiana Chacón
Background: Chronic systemic inflammation is implicated in Alzheimer's disease (AD) pathogenesis and has measurable effects on blood cells. There is increasing interest in non-invasive diagnostic tools that use blood-base...
Targeting the chemokine-microglia nexus: A novel strategy for modulating neuroinflammation in Alzheimer's disease [0.03%]
靶向趋化因子-小胶质细胞轴：一种调节阿尔茨海默病神经炎症的新策略
Bingyang Xu,Chao Tang,Rongshou Han et al.
Bingyang Xu et al.
An increasing body of evidence suggests neuroinflammation has a prominent role in the pathogenesis of Alzheimer's disease (AD). The amyloid-β-tau-neurodegeneration (ATN) classification system is now being expanded toward an amyloid-β-tau ...
Alzheimer's disease and the immune system: A comprehensive overview with a focus on B cells, humoral immunity, and immunotherapy [0.03%]
阿尔茨海默病与免疫系统：以B细胞、体液免疫和免疫治疗为重点的全面综述
Ladan Gol Mohammad Pour Afrakoti,Sanam Daneshpour Moghadam,Pezhman Hadinezhad
Ladan Gol Mohammad Pour Afrakoti
Alzheimer's disease (AD) is a complex neurodegenerative disorder and the major cause of dementia. Amyloid-β (Aβ) and tau aggregation, mitochondrial dysfunction, and microglial dysregulation are key contributors to AD pathogenesis. Impairm...
The impact of prolonged high-concentration cortisol exposure on cognitive function and risk factors: Evidence from Cushing's disease patients [0.03%]
长期高浓度皮质醇暴露对认知功能和危险因素的影响：库欣病患者的证据
Yuxiang Sun,Junpeng Xu,Xiaoque Zheng et al.
Yuxiang Sun et al.
Background: Prolonged high-concentration cortisol exposure may impair cognitive function, but its mechanisms and risk factors remain unclear in humans. Ob...
The relationship of 18F-FDG-PET to other common biomarkers of dementia in a clinical cohort with memory deficits [0.03%]
氟脱氧葡萄糖正电子发射断层扫描与痴呆症其他常见生物标志物在有记忆减退临床队列中的关系
Katharina Woyk,Niels Hansen,Jens Wiltfang et al.
Katharina Woyk et al.
Background: Early biomarker-based diagnosis of Alzheimer's disease (AD) is essential, particularly with the increasing availability of new therapeutic options. However, the relationship between imaging and cerebrospinal f...
Long-term safety and tolerability of brexpiprazole for Japanese patients with agitation in Alzheimer's disease dementia: A multicenter, open-label study [0.03%]
艾伯维依立派佐治疗阿尔茨海默病激越的长期安全性和耐受性：一项多中心开放标签研究
Yu Nakamura,Jun Adachi,Naoki Hirota et al.
Yu Nakamura et al.
Background: The long-term safety and efficacy of brexpiprazole in Asian patients with agitation associated with dementia due to Alzheimer's disease are unknown. ...