Healthcare related costs associated with donepezil use in patients with very mild dementia due to Alzheimer's disease: A retrospective observational study [0.03%]
评估多奈哌齐治疗轻度阿尔茨海默病患者的费用效果：回顾性观察研究
Sun-Wung Hsieh,Chen-Yang Hsiao,Yuan-Han Yang et al.
Sun-Wung Hsieh et al.
Background: The cost-effectiveness of Donepezil in mild to severe Alzheimer's disease (AD) has been widely studied, but research on very mild dementia (VMD) remains limited. ...
Exploring causal links between brain functional networks and neurodegenerative disease risk using Mendelian randomization [0.03%]
使用孟德尔随机化研究大脑功能网络与神经退行性疾病风险之间的因果关系
Xiangzan Wei,Weirong Qin
Xiangzan Wei
Background: Resting-state functional magnetic resonance imaging (rsfMRI) is pivotal for mapping alterations in brain functional networks associated with neurodegenerative diseases, particularly Alzheimer's disease (AD). H...
Functional connectivity alterations in women with subjective cognitive decline [0.03%]
主观认知下降女性的大脑功能连接改变
Ashleigh F Parker,Cassandra Szoeke,Heather Kwan et al.
Ashleigh F Parker et al.
Background: Alzheimer's disease (AD) is an incurable neurodegenerative disorder, which disproportionately affects women. Along the continuum of dementia, those who experience subjective cognitive decline (SCD) are thought to be the earliest...
Purpose and meaning in life and the trajectory of episodic memory in eight longitudinal samples [0.03%]
人生的意义与目的和八个纵向样本中的情节记忆的轨迹
Angelina R Sutin,Justin Brown,Martina Luchetti et al.
Angelina R Sutin et al.
Background: Higher purpose and meaning in life are associated with lower risk of Alzheimer's disease and related dementias. Change in memory over time may be an early indicator of oncoming cognitive impairment and, even i...
miR-137: A therapeutic candidate or a key molecular regulator in Alzheimer's disease? [0.03%]
MiR-137：阿尔茨海默病的治疗靶点还是关键分子调控因子？
Muhammad Wasim,Junhao Guo,Zhendong Wang et al.
Muhammad Wasim et al.
Alzheimer's disease (AD) is a neurodegenerative disorder driven by amyloid-β accumulation, tau pathology, and synaptic dysfunction. Recent studies highlight miR-137, a brain-enriched microRNA, as a pivotal regulator of AD pathogenesis. Thi...
Insights into the role of cerebrospinal fluid cytokines in Alzheimer's disease: A commentary on recent findings [0.03%]
脑脊液细胞因子在阿尔茨海默病中的作用机制：对近期研究结果的评论
Carlo Manco,Matteo Pardini,Delia Righi et al.
Carlo Manco et al.
We read the study by Bruno et al. (2025), which highlights the interplay between neuroinflammation and cortical activity in Alzheimer's disease (AD). Their findings on IL-4, IL-7, IL-8, and IL-12 levels and their association with EEG altera...
A novel PSEN2 mutation in amnestic early-onset Alzheimer's disease (EOAD): A familial case series [0.03%]
早发性阿尔茨海默病(PSEN2突变)家族病例系列研究
Carl Froilan D Leochico,Ekaterina Rogaeva,Ljubica Zotovic et al.
Carl Froilan D Leochico et al.
Familial early-onset Alzheimer's disease (EOAD) is a rare form of dementia often caused by autosomal dominant mutations in APP, PSEN1, or PSEN2. We report a novel PSEN2 missense variant (c.359T > G, p.Ile120Ser) that has been detected in fo...
Predicting brain health in community-dwelling elderly populations by integrating Gaussian mixture model and plasma biomarkers [0.03%]
基于高斯混合模型和血浆生物标志物的社区老年人脑健康预测
Yue Wang,Tianshu Zhu,Qian Cheng et al.
Yue Wang et al.
Background: Alzheimer's disease (AD) is the most common type of dementia, and early screening is crucial for intervention. Objective: C...
Lin Du,Ge Li,Yinxiang Wei et al.
Lin Du et al.
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders and is characterized by memory loss and cognitive decline. The amyloid cascade hypothesis posits that the pathogenesis of AD is initiated by the oligomerizati...
Education and age of decline in verbal memory across countries: Evidence from the HRS, MHAS, and CHARLS [0.03%]
教育与口头记忆下降年龄跨国家分析：来自HRS、MHAS和CHARLS的证据
Chengming Han,Octavio N Bramajo,Brian Downer
Chengming Han
Background: Despite the well-established association between education and cognition in old age, age-related changes in cognition by education across different contexts remain underexplored. ...