The association of specific and cumulative exposure to infectious agents with cognitive impairment in older Hispanic adults [0.03%]
特定病原体和累积病原体暴露与老年西班牙裔成年人认知障碍的关系
Giselle A Rangel,Berta A Muñoz,Morgan Ramirez et al.
Giselle A Rangel et al.
Background: Accumulating evidence implicates infectious pathogens as triggers of immune-inflammatory processes that contribute to neurodegeneration. Inflammation in both the brain and peripheral circulation is recognized ...
Higher p-Cresol sulfate and tumor necrosis factor (TNF)-α levels are associated with cognitive improvement through increased TNF receptor 2 in individuals with mild cognitive impairment: A cross-sectional mediation analysis [0.03%]
较高的对甲苯硫酸和肿瘤坏死因子(TNF)-α水平通过增加TNF受体2与轻度认知障碍患者的认知改善相关：横断面中介分析
Ali Azargoonjahromi,Hamide Nasiri;Alzheimer’s Disease Neuroimaging Initiative
Ali Azargoonjahromi
Background: Neuroinflammation in neurocognitive disorders is driven by the release of tumor necrosis factor (TNF)-α from brain immune cells in response to injury, infection, or p-Cresol sulfate (p-CS)-a metabolite associ...
Relationship between extracranial carotid artery calcification and amyloid-β deposition in the brain among the very old: A retrospective study [0.03%]
一项回顾性研究：非常老年的受试者颅外颈动脉钙化与脑内淀粉样蛋白沉积的关系
Jiatong Li,Emma Barinas-Mitchell,Yuefang Chang et al.
Jiatong Li et al.
Background: Extracranial carotid artery calcification (ECAC) is a known risk factor for the development of cardiovascular diseases (CVD) and has been associated with an increased risk of dementia and Alzheimer's disease. ...
Association between genetically proxied PPARG activation and early onset Alzheimer's disease: A drug target Mendelian randomization study [0.03%]
基于遗传代理的PPARG激活与早发性阿尔茨海默病关联的孟德尔随机化研究
Lingyu Zhang,Yi Wu,Qianqian Jin et al.
Lingyu Zhang et al.
Background: Early-onset Alzheimer's disease (EOAD), which has an onset before the age of 65, is overshadowed by the more prevalent late-onset Alzheimer's disease (LOAD). Nevertheless, rather than being merely a form of LO...
Insulin resistance and Alzheimer's disease: Exploring research hotspots and frontiers from a bibliometric and visual analysis (2005-2024) [0.03%]
胰岛素抵抗与阿尔茨海默病：基于文献计量学和可视化分析的研究热点与前沿探索（2005-2024）
Yabin Zhang,Yuting Lv,Tiantian Yang et al.
Yabin Zhang et al.
Background: Alzheimer's disease (AD) and insulin resistance (IR) share intersecting pathological pathways, with IR increasingly implicated in AD pathogenesis. Systematic bibliometric analyses mapping the evolution of this...
Cognitive impairment in cerebellar phenotype of multiple system atrophy and its association with hot-cross bun sign [0.03%]
多系统萎缩小脑型认知障碍及其与英式面包征的关联性
Wenxiang Liao,Danlei Chen,Yuyuan Huang et al.
Wenxiang Liao et al.
Background: Cognitive impairment has been reported in patients with cerebellar phenotype of multiple system atrophy (MSA-C), yet this area remains largely unexplored. ...
Identification and experimental validation of Alzheimer's disease hub genes via bioinformatics and machine learning [0.03%]
利用生物信息学和机器学习鉴定并通过实验验证阿尔茨海默病关键基因
Ying Hu,Zhaoshuyu Pan,Jianping Li et al.
Ying Hu et al.
Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder. Objective: To identify diagnostic and predictive biomarke...
Performance change while learning novel cognitive tasks as a potential identifier of preclinical Alzheimer's disease [0.03%]
作为潜在标识的阿尔茨海默病前期学习新认知任务时的表现变化
Lena M Hetrick,Haiying Chen,Ilana Levin et al.
Lena M Hetrick et al.
Background: In healthy older adults (OA), the effects of amyloid-β (Aβ) deposition on cognitive functions involved in learning are unclear. Objective: ...
Ozlem Totuk,Nazire Çelem,Sevki Sahin
Ozlem Totuk
We report a case of young-onset dementia (YOD) in a 40-year-old male with a heterozygous missense variant in the PDGFRβ gene. The patient exhibited progressive memory decline and disorientation. Brain MRI and cerebrospinal fluid biomarkers...
Disease progression from mild cognitive impairment to dementia for patients with Alzheimer's disease or Lewy body pathology [0.03%]
阿尔茨海默病或路易体病理患者的轻度认知障碍向痴呆进展状况
Guogen Shan,Yahui Zhang
Guogen Shan
Background: The majority of mild cognitive impairment (MCI) patients who converted to dementia in later years have Alzheimer's disease (AD) pathology. The second most common type of dementia is Lewy body (LB) dementia. ...