Notch1 Drives the Formation and Proliferation of Intrahepatic Cholangiocarcinoma [0.03%]
NOTCH1促进肝内胆管癌的发生和增殖
Jun Guo,Wen Fu,Ming Xiang et al.
Jun Guo et al.
The molecular mechanisms underlying the development of intrahepatic cholangiocarcinoma (ICC) are not clear yet. In this study, we investigated the involvement of Notch1 in the development of ICC. The cDNA microarray analysis showed that Not...
Protective Effects of α-Lipoic Acid on Vascular Oxidative Stress in Rats with Hyperuricemia [0.03%]
α-亚麻酸对高尿酸血症血管氧化应激的保护作用研究
Wei Xiang,Li Wang,Shi Cheng et al.
Wei Xiang et al.
The aim of the present study was to observe the protective effects of α-lipoic acid (ALA) on vascular injury in rats with hyperuricemia (HUA). The ALA treatment groups (10, 30 and 90 mg/kg, respectively) were administered with ALA via gava...
Diwu Yanggan Modulates the Wnt/β-catenin Pathway and Inhibits Liver Carcinogenesis Signaling in 2-AAF/PH Model Rats [0.03%]
二戊烯洋甘菊内酯通过调控Wnt/β-catenin信号通路抑制肝癌发生信号-以2-AAF/PH模型大鼠为例
Bin-Bin Zhao,Zhi-Hua Ye,Xiang Gao et al.
Bin-Bin Zhao et al.
The activation of the Wnt/β-catenin signaling pathway in oval cells after liver injury is implicated in hepatocarcinogenesis. Diwu Yanggan capsule is a Chinese herbal medicine that has been used for treating liver disorder. The present stu...
Dectin-1 rs3901533 and rs7309123 Polymorphisms Increase Susceptibility to Pulmonary Invasive Fungal Disease in Patients with Acute Myeloid Leukemia from a Chinese Han Population [0.03%]
Dectin-1基因多态性通过影响免疫功能增加中国人急性髓系白血病肺侵袭性真菌病的易感性
Mei-Jing Chen,Rong Hu,Xiao-Ying Jiang et al.
Mei-Jing Chen et al.
This study aimed to assess whether genetic variants of dendritic cell-associated C-type lectine-1 (Dectin-1), Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), and myeloid differentiation primary response 88 (MyD88) influence the su...
Short-lived AIM2 Inflammasome Activation Relates to Chronic MCMV Infection in BALB/c Mice [0.03%]
AIM2炎症小体的瞬时活化与BALB/c小鼠慢性MCMV感染有关
Yuan-Yuan Lu,Xing-Lou Liu,Yuan Huang et al.
Yuan-Yuan Lu et al.
Absent in melanoma 2 (AIM2) inflammasome is a crucial link bridging the innate host defense and the subsequent adaptive immunity when activated by exogenous double stranded DNA (dsDNA). Through establishing models of disseminated murine cyt...
Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation [0.03%]
甘草提取物通过抑制凋亡和STAT3活化减轻巴曲毒素诱导的肾毒性
Min Zhang,Chao Wang,Hua-Lin Cai et al.
Min Zhang et al.
Licorice, one of the most widely used medicinal herbs in East Asia, has effects such as anti-inflammation, antioxidant, and detoxifying. This study aimed to evaluate the protective effect of licorice on brucine-induced nephrotoxicity. Sprag...
Gut Microbiota Reconstruction Following Host Infection with Blood-stage Plasmodium berghei ANKA Strain in a Murine Model [0.03%]
疟原虫ANKA株感染对小鼠肠道菌群的影响及其重建规律研究
Zhi-Gang Fan,Xiao Li,Hai-Yi Fu et al.
Zhi-Gang Fan et al.
Malaria remains a global health problem. The relationship between Plasmodium spp. and the gut microbiota as well as the impact of Plasmodium spp. on the gut microbiota in vertebrate hosts is unclear. The aim of the current study was to eval...
Xin Yang,Gao-Xiang Wang,Jian-Feng Zhou
Xin Yang
As a rapidly progressing field in oncology, the adoptive transfer of T cells that have been genetically modified with chimeric antigen receptors (CARs) has shown striking efficacy in the management of hematological malignancies and has been...
Voltage-gated Sodium Channels and Blockers: An Overview and Where Will They Go? [0.03%]
电压门控钠通道及其阻断剂的研究现状与展望
Zhi-Mei Li,Li-Xia Chen,Hua Li
Zhi-Mei Li
Voltage-gated sodium (Nav) channels are critical players in the generation and propagation of action potentials by triggering membrane depolarization. Mutations in Nav channels are associated with a variety of channelopathies, which makes t...
Body Weight Misperception and Weight Disorders among Chinese Children and Adolescents: A Latent Class Analysis [0.03%]
中国儿童和青少年的体重感知偏差及体重异常：潜类分析
Ting-Ting Qin,Huang-Guo Xiong,Ming-Ming Yan et al.
Ting-Ting Qin et al.
Body misperception plays an important role in the development of weight and dietary disorders among children and adolescents. A school-based health promotion program (2014-2015) was conducted to promote the school health education and impro...