Burden of Non-communicable Diseases Attributable to High and Low Ambient Temperatures, 1990-2031: A Forecasting Analysis for GBD 2021 [0.03%]
1990年至2031年的全球疾病负担研究（GBD 2021）中归因于高温和低温的非传染性疾病负担：一项预测分析
Li Pu,Huan-Huan Wang,Xiang-Wei Cheng et al.
Li Pu et al.
Objective: Non-communicable diseases (NCDs), characterized by long duration, gradual progression, and high morbidity, have emerged as a fundamental threat to global public health. Furthermore, dramatic climate change may ...
Development of mRNA Cancer Vaccines: Delivery Strategies and Immunogenicity Optimization [0.03%]
mRNA癌症疫苗的研发：传递策略和免疫原性优化
Awais Ali
Awais Ali
mRNA vaccines have emerged as a transformative platform in oncology, offering significant advantages in rapid development, flexibility, and safety over traditional modalities. However, their clinical translation faces challenges such as mRN...
Clinical Characteristics of Intermittent Exotropia in Children with Myopia and Myopic Anisometropia [0.03%]
近视与远视散光患儿间歇性外斜视的临床特征分析
Li-Ping Zhang,Chun-Xia Peng,Li Li
Li-Ping Zhang
Objective: Previous studies have yielded contradictory conclusions on the relationship between intermittent exotropia (IXT) and the magnitude of myopia, especially in children. The aim of this study was to determine the c...
ARHGEF15 Promotes Endothelial Cell Migration Through the Regulation of STAT3 Signaling [0.03%]
ARHGEF15通过调节STAT3信号促进内皮细胞迁移
Shan-Shan Shi,Yu-Xuan Shang,Peng Gao et al.
Shan-Shan Shi et al.
Objective: Rho guanine nucleotide exchange factor 15 (ARHGEF15) is a member of the RhoGEF family that activates the Rho protein. High ARHGEF15 expression is associated with poor prognosis in patients with pancreatic cance...
Electroacupuncture-Medication Combined Therapy Improves Sepsis Outcomes by Regulating PVN Neuronal Activities [0.03%]
电针药物联合治疗通过调节PVN神经元活性改善脓毒症预后
Hong-Xia Ren,Zi-Xiao Wang,Jia-Bao Liu et al.
Hong-Xia Ren et al.
Objective: Sepsis, a life-threatening condition caused by a dysregulated host response to infection, continues to be a major cause of mortality in critical care despite medical advancements. This study aimed to investigat...
LncRNA C9orf139 Promotes Acute Myeloid Leukemia Cell Proliferation by Sponging miR-24-3p to Upregulate TAOK1 [0.03%]
长链非编码RNA C9orf139通过海绵吸附miR-24-3p来上调TAOK1以促进急性髓系白血病细胞增殖
Wei Qin,Mei-Yu Chen,Xiao-Hui Cai et al.
Wei Qin et al.
Objective: Long non-coding RNAs (lncRNAs) are critical in the pathogenesis of hematological malignancies, including acute myeloid leukemia (AML). However, the specific role and underlying mechanisms of the lncRNA chromoso...
Impact of Statin Therapy on Long-Term Survival of Patients with Chronic Kidney Disease but Without Atherosclerotic Cardiovascular Disease: Insights from the American MIMIC-IV and Chinese CIN-II Databases [0.03%]
他汀类药物治疗对无动脉粥样硬化性心血管疾病慢性肾病患者的长期生存影响：美国MIMIC-IV数据库和中国CIN-II数据库的见解
Wei-Peng Zhang,Huang-Tao Ruan,Xian-Lin Ruan et al.
Wei-Peng Zhang et al.
Objective: Patients with chronic kidney disease (CKD) without atherosclerotic cardiovascular disease (ASCVD) have high mortality rates. Guidelines indicate that statin therapy can reduce mortality in CKD patients with ASC...
Data Mining of Adverse Reactions to Iodinated Contrast Media Based on a Municipal Spontaneous Reporting System in China [0.03%]
基于中国城市自发报告系统的碘对比剂不良反应数据挖掘分析
Wen-Ting Zhang,Wei-Jie Li,Jin-Wen Zhang et al.
Wen-Ting Zhang et al.
Objective: Iodinated contrast media (ICM) are widely used in medical imaging, particularly in computed tomography (CT) and magnetic resonance imaging (MRI) examinations, to increase image quality and improve diagnostic ac...
PPA1 Facilitates Thermogenesis in Brown and Beige Fat by Regulating the Mitochondrial Localization of FUS [0.03%]
PPA1通过调节FUS的线粒体定位促进棕色和米色脂肪组织中的产热作用
Yue Sun,Heng-le Ding,Jin-Fu Zhang et al.
Yue Sun et al.
Objective: Brown and beige adipocytes dissipate energy through thermogenesis, and the impaired thermogenic function of these adipocytes is a key driver of obesity and related metabolic disorders. However, the molecular me...
Ze-Han Huang,Ran He
Ze-Han Huang
Acute myeloid leukemia (AML) is a common and aggressive blood cancer characterized by the abnormal growth of primitive bone marrow cells. Genetic mutations prevent normal differentiation into blood components. Potential causes include envir...