Efficacy and Mechanisms of Duhuo Jisheng Decoction in Treating Intervertebral Disc Degeneration: A Network Pharmacology and Experimental Study [0.03%]
Jing Feng,Lei Xu,Hong-Yan Miao et al.
Jing Feng et al.
Objective: Intervertebral disc degeneration (IDD) is the main cause of low back pain, which is closely related to an imbalance in extracellular matrix decomposition-anabolism mediated by immune inflammation. Duhuo Jisheng...
Matteo Guarino,Roberto De Giorgio
Matteo Guarino
Atrial fibrillation (AF) is a frequent arrhythmia in sepsis patients and is traditionally regarded as a harmful epiphenomenon requiring immediate correction. Its abrupt onset and association with adverse outcomes have driven clinicians to p...
UXS1 Knockdown Suppresses Cell Proliferation and Invasion in Hepatocellular Carcinoma by Inducing Ferroptosis via SLC7A11/GPX4 Pathway [0.03%]
Jun Lv,Kang Han,Fu-Yuan Gan et al.
Jun Lv et al.
Objective: Identifying novel molecular drivers is crucial to improving therapeutic strategies for hepatocellular carcinoma (HCC). This study aimed to investigate the clinical significance and biological function of UDP-gl...
ATF6 Identification Sensitizes B-Cell Precursor Acute Lymphoblastic Leukemia Cells to Doxorubicin [0.03%]
ATF6鉴定使B细胞前体急性淋巴细胞白血病细胞对阿霉素敏感
Samira Rahimi,Bahman Zarandi,Rima Manafi Shabestari et al.
Samira Rahimi et al.
Objective: Activating transcription factor 6 (ATF6) is a part of the unfolded protein response (UPR) system, which plays an important role in regulating endoplasmic reticulum stress. The overexpression of ATF6 has been re...
Screening and Functional Validation of Common Key Genes in Hypertrophic Cardiomyopathy and Ischemic Cardiomyopathy [0.03%]
肥厚型心肌病和缺血性心肌病共有关键基因的筛选及功能验证
Ping Jiang,Kai-Shen Cao,Ya-Jiao Liu et al.
Ping Jiang et al.
Objective: Hypertrophic cardiomyopathy (HCM) and ischemic cardiomyopathy (ICM) are the most common main etiologies of heart failure (HF), which is also a leading cause of mortality and morbidity; however, the common mecha...
HLA-E as an Emerging Checkpoint and Biomarker in Personalized Cancer Immunotherapy [0.03%]
HLA-E在个性化癌症免疫治疗中的新兴检查点和生物标志物作用
Rajeswary Sanmugawil,Lhoshiny Parmeswaran,Nafisah Abdul Rahman et al.
Rajeswary Sanmugawil et al.
Human leukocyte antigen (HLA) molecules play a predominant role in cancer immunotherapy by harnessing the immune system's capacity to differentiate between healthy and malignant cells. Most human cell types express HLA class I molecules, wh...
Trehalose: A Promising Therapeutic Agent for Diverse Pathological Conditions [0.03%]
海藻糖：一种颇具潜力的治疗多种病理状况的药物
Mahboobeh Ghasemzadeh Rahbardar,Prashant Kesharwani,Amirhossein Sahebkar
Mahboobeh Ghasemzadeh Rahbardar
Trehalose, a naturally occurring disaccharide, is gaining recognition for its therapeutic potential across a wide range of disorders. This review highlights the increasing importance of trehalose in clinical research and its applications in...
MRPL42 Knockdown Suppresses the Malignant Functions of Hepatocellular Carcinoma by Regulating Oxidative Phosphorylation [0.03%]
MRPL42敲低通过调节氧化磷酸化抑制肝细胞癌的恶性功能
Jun Lv,Fu-Yuan Gan,Ming-Hao Li et al.
Jun Lv et al.
Objective: The diagnosis and treatment of hepatocellular carcinoma (HCC) remain unsatisfactory, underscoring the urgent need to explore new regulatory factors. This study aimed to uncover the regulatory role of mitochondr...
PAR-1 in Alzheimer's Disease: Pathophysiological Insights and Mechanistic Perspectives [0.03%]
阿尔茨海默病中的PAR-1：病理生理学见解和机制视角
Neha,Snehashis Mandal,Vipual Sharma et al.
Neha et al.
The G protein-coupled receptor (GPCR) known as protease-activated receptor-1 (PAR-1) is triggered by thrombin and plays a multifaceted role in the onset and progression of Alzheimer's disease (AD). AD is an irreversible neurodegenerative di...
Overexpression of TFF3 is Associated with Immune Infiltration, Molecular Subtypes, and Clinical Progression in Breast Cancer [0.03%]
TFF3过表达与乳腺癌的免疫浸润、分子亚型及临床病程相关性研究
Bei Liu,Qin Wang,Rong-Fu Huang et al.
Bei Liu et al.
Objective: Trefoil factor 3 (TFF3), a secreted protein involved in mucosal protection and tumor progression, has an incompletely defined role in breast cancer (BRCA). This study aimed to comprehensively evaluate TFF3 expr...