Blood Trihalomethane Concentrations and Gestational Diabetes Mellitus: A Nationwide Cross-Sectional Study [0.03%]
三卤甲烷浓度与妊娠糖尿病的关系：一项全国性横断面研究
Zhi-Min Deng,Juan He,Wen-Zhu Li et al.
Zhi-Min Deng et al.
Background and objective: Growing evidence suggests that environmental pollutants may increase the risk of gestational diabetes mellitus (GDM). This study aimed to assess the association between blood concentrations of t...
Intestinal Epithelial Cell Ferroptosis in Ulcerative Colitis: Pathogenesis, Signaling Networks, and Therapeutic Implications [0.03%]
溃疡性结肠炎中的肠上皮细胞铁死亡：发病机制、信号通路及其治疗意义
Zhi-Qiang Zhao,Zhou-Xin Yu,Zhi-Qiu Liu et al.
Zhi-Qiang Zhao et al.
The ferroptosis of intestinal epithelial cells (IECs), an iron-dependent form of cell death driven by lipid peroxidation, has emerged as a critical pathogenic driver of ulcerative colitis (UC). This review summarizes the core hallmarks of I...
Hypoxia-Induced PTPRN2 Suppresses Trophoblast Invasion via Wnt/β-Catenin Pathway Inhibition [0.03%]
缺氧诱导的PTPRN2通过抑制Wnt/β-catenin信号通路抑制胎盘滋养细胞侵袭作用
Tong Zhu,Wan-Jiang Zeng,Ying Zhang
Tong Zhu
Objective: Disruptions to trophoblast infiltration and placental implantation are recognized as pivotal early mechanisms underlying the pathogenesis of preeclampsia. Previous studies have reported the aberrant expression ...
Sijunzi Decoction Reverses Metabolic Adaptation and Induces Ferroptosis in Cisplatin-Resistant Non-small Cell Lung Cancer: An Integrative Metabolomics-Pharmacology Analysis [0.03%]
四君子汤逆转顺铂耐药非小细胞肺癌代谢适应并诱导铁死亡的整合代谢组学与药理学分析
Wen-Jun Liu,Han-Yu Dong,Chun-Ying Liu et al.
Wen-Jun Liu et al.
Objective: To investigate the mechanistic role of Sijunzi decoction (SJZD) in overcoming chemoresistance through the suppression of adaptive metabolic responses in non-small cell lung cancer (NSCLC). ...
Glucose Metabolic Reprogramming in Thyroid Cancer: Underlying Molecular Mechanisms and Links to Progression and Treatment [0.03%]
甲状腺癌中的葡萄糖代谢重塑：潜在的分子机制及其与病情进展和治疗的关系
Yi-Meng Zhang,Xin-Yu Zeng,Yuan Wang et al.
Yi-Meng Zhang et al.
Thyroid cancer (TC) is a common endocrine malignancy with rapidly increasing global incidence. Clinical management remains challenging for advanced and radioiodine-refractory thyroid cancer (RAIR-TC). Metabolic reprogramming, especially enh...
Multi-Omics Analysis Reveals Inflammatory Activation and Maternal-Fetal Interface Remodeling in Spontaneous Abortion [0.03%]
多组学分析揭示了自发性流产的炎症活化和母胎界面重塑
Yan-Juan Huang,Zou-Qin-Xuan Shen,Dan-Ping Hu et al.
Yan-Juan Huang et al.
Background: Spontaneous abortion (SA) is a common adverse outcome of early pregnancy, yet its underlying pathophysiological mechanisms remain incompletely understood. Accumulating evidence suggests that dysregulated infla...
Fan Li,Yan-Jing Huang,Yu-Li Geng et al.
Fan Li et al.
Premature ovarian insufficiency (POI) is a harmful disease that leads to decreased fertility and osteoporosis and an increased risk of cardiovascular disease. POI seriously affects women's physical and mental health. Currently, the incidenc...
Integrated DNA Repair Capacity and NER Gene Expression for Improving Risk Prediction in Head and Neck Squamous Cell Carcinoma [0.03%]
整合DNA修复能力和NER基因表达以改善头颈鳞状细胞癌的风险预测能力
Ling Zhang,Yi-Qian Liang,Xiao-Rong Niu et al.
Ling Zhang et al.
Objective: DNA repair plays a critical role in the development of smoking-related cancers. We hypothesized that DNA repair capacity (DRC) and nucleotide excision repair (NER) mRNA expression are associated with increased ...
A Novel Nomogram for Predicting Meningioma Grade Based on Radiomics Features and Clinical Characteristics [0.03%]
基于影像组学特征和临床特点的脑膜瘤分级列线图模型研究
Peng-Fei Yan,Bao-Ping Zheng,Ye Yuan et al.
Peng-Fei Yan et al.
Objective: This study aimed to develop a predictive model utilizing radiomics features and clinical characteristics to accurately differentiate low-grade (WHO grade I) from high-grade (WHO grade II/III) meningiomas preope...
Targeting the Gut Microbiota-Bile Acid-FXR Axis: The Therapeutic Mechanism of Yudantong Decoction in Cholestatic Liver Disease [0.03%]
针对肠道菌群-胆汁酸-FXR轴：郁导汤治疗胆汁淤积性肝病的机制研究
Xiao-Ming Wu,Lin-Yi Hou,Chang Liu et al.
Xiao-Ming Wu et al.
Objective: To elucidate the therapeutic mechanism of Yudantong decoction (YDTD) in cholestatic liver disease (CLD), focusing on the gut microbiota-bile acid-intestinal farnesoid X receptor (FXR) axis. ...