Activating PPARγ Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia [0.03%]
激活PPARγ通过Nrf2增加促血管生成因子诱导的微胶质细胞中NQO1和γ-GCS的表达
Hang Hang,Li-Kun Wang,Si-Ying Ren et al.
Hang Hang et al.
The present study aimed to explore the molecular mechanisms underlying the increase of nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1 (NQO1) and γ-glutamylcysteine synthetase (γ-GCS) in brain tissues after intracereb...
CTRP1 Attenuates UUO-induced Renal Fibrosis via AMPK/NOX4 Pathway in Mice [0.03%]
CTRP1通过AMPK/NOX4途径减轻UUO诱导的小鼠肾纤维化
Wen Li,Fan Cheng,Yi-Yan Songyang et al.
Wen Li et al.
C1q/TNF-related protein 1 (CTRP1), a conserved protein of the C1q family, plays a key role in cardiovascular and metabolic diseases. However, the role of CTRP1 in renal injury is unclear. The purpose of this study is to explore the role of ...
Inhibition of NF-κB and Wnt/β-catenin/GSK3β Signaling Pathways Ameliorates Cardiomyocyte Hypertrophy and Fibrosis in Streptozotocin (STZ)-induced Type 1 Diabetic Rats [0.03%]
NF-κB和Wnt/β-catenin/GSK3β信号通路的抑制可改善链脲佐菌素(STZ)诱导的一型糖尿病大鼠心肌细胞肥大和平滑肌纤维化现象
Jing-Jing Liu,Lu-Mei Shentu,Ning Ma et al.
Jing-Jing Liu et al.
Type 1 diabetes mellitus (T1DM) is associated with an increased risk of diabetic cardiomyopathy (DCM). Nuclear factor kappa B (NF-κB) and Wnt/β-catenin/GSK3β have been demonstrated to play pathogenic roles in diabetes. In this study, we ...
Selection for Anti-transferrin Receptor Bispecific T-cell Engager in Different Molecular Formats [0.03%]
不同分子形式的抗转铁蛋白受体双特异性T细胞接头的选择性
Ming-Peng Fu,Zi-Long Guo,Hong-Ling Tang et al.
Ming-Peng Fu et al.
Selecting an ideal molecular format from diverse structures is a major challenge in developing a bispecific antibody (BsAb). To choose an ideal format of anti-CD3 × anti-transferrin receptor (TfR) bispecific antibodies for clinical applica...
Epigallocatechin-3-gallate Alleviates Cognitive Deficits in APP/PS1 Mice [0.03%]
表没食子儿茶素没食子酸酯通过改善内稳态失衡缓解APP/PS1小鼠认知缺陷作用研究
Jian Bao,Wei Liu,Hong-Yan Zhou et al.
Jian Bao et al.
Alzheimer's disease (AD) shows cognitive impairments in clinic, which is multifactorial with different etiopathogenic mechanisms such as Aβ deposition, neuroinflammation and neuronal dystrophy involved. Therefore, multi-targets drugs with ...
A Novel Surgery Classification for Endoscopic Approaches to Middle Ear Cholesteatoma [0.03%]
内镜中耳胆脂瘤手术的新型术式分类方法研究
Yu Sun,En-Hao Wang,Jin-Tao Yu et al.
Yu Sun et al.
This study aimed to develop a novel surgery classification for an endoscopic approach to middle ear cholesteatoma. We retrospectively analyzed the surgical approaches and outcomes of patients with middle ear cholesteatoma. Middle ear choles...
Protein Phosphatase 2A as a Drug Target in the Treatment of Cancer and Alzheimer's Disease [0.03%]
蛋白磷酸酶2A作为抗癌和治疗阿尔茨海默病的药物靶点
Hui Wei,Hui-Liang Zhang,Jia-Zhao Xie et al.
Hui Wei et al.
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase which participates in the regulation of multiple cellular processes. As a confirmed tumor suppressor, PP2A activity is downregulated in tumors and its re-activation can i...
Patellofemoral MRI Alterations Following Single Bundle ACL Reconstruction with Hamstring Autografts Are Associated with Quadriceps Femoris Atrophy [0.03%]
内侧髌股韧带单束前交叉韧带重建术后股四头肌萎缩与MR影像变化有关
Wei-Song Cai,Hao-Huan Li,Shin-Ichi Konno et al.
Wei-Song Cai et al.
High incidence of patellofemoral pain and patellofemoral joint osteoarthritis was found following anterior cruciate ligament (ACL) reconstruction. The unstability of patellofemoral joint might be an important contribution factor. This study...
Adverse Effects of Exposure to Fine Particulate Matters and Ozone on Gestational Hypertension [0.03%]
细颗粒物和臭氧暴露对子痫前期发病的效应研究
Rong Yang,Dan Luo,Yi-Ming Zhang et al.
Rong Yang et al.
Gestational hypertension (GH) is a common complication during pregnancy. GH is regarded as a potential public health challenge for pregnant women and infants. Limited evidence has linked ambient air pollution to an increased GH risk. Howeve...
Risk Factors and Management of Postoperative Pancreatic Fistula Following Pancreaticoduodenectomy: Single-center Experience [0.03%]
术后胰腺漏的风险因素及管理（胰十二指肠切除术单中心经验）
Zun-Xiang Ke,Jiong-Xin Xiong,Jin Hu et al.
Zun-Xiang Ke et al.
Pancreatic fistula (PF) remains the most frequent complication after pancreaticoduodenectomy (PD). This study was undertaken to explore the risk factors of postoperative PF following PD and discuss the management of PF in our center. A sing...