Epigenetic Modifications in Sensorineural Hearing Loss: Protective Mechanisms and Therapeutic Potential [0.03%]
听神经性听力损失中的表观遗传修饰：保护机制与治疗潜力
Jia-Huan Li,Chang Liu,Si-Yu Qiu et al.
Jia-Huan Li et al.
Hearing loss, which currently affects more than 430 million individuals globally and is projected to exceed 700 million by 2050, predominantly manifests as sensorineural hearing loss (SNHL), for which existing technologies such as hearing a...
ELMOD2 Overexpression Predicts Adverse Outcomes and Regulates Tumor Progression in Gliomas [0.03%]
ELMOD2过表达与胶质瘤不良预后及肿瘤进展关联的研究
Rui-Chao Li,Chang Liu,Guo-Jian Wang et al.
Rui-Chao Li et al.
Objective: Glioma is a highly heterogeneous and malignant intracranial tumor that presents challenges for clinical treatment. ELMO domain containing 2 (ELMOD2) is a GTPase-activating protein that regulates a range of cell...
Development and Application of the Portable Electromagnetic Navigation for Neurosurgery [0.03%]
一种神经外科电磁导航系统的研发及其临床应用效果分析
Sheng-Kun Lang,Zhi-Chao Gan,Qun Wang et al.
Sheng-Kun Lang et al.
Background and objective: Electromagnetic navigation technology has demonstrated significant potential in enhancing the accuracy and safety of neurosurgical procedures. However, traditional electromagnetic navigation syst...
Targeting miR-144-5p/ACSM1 Axis Alleviates Doxorubicin-Induced Heart Failure by Inhibiting Lipid Peroxidation [0.03%]
靶向miR-144-5p/ACSM1轴通过抑制脂质过氧化缓解多柔比星诱导的心力衰竭
Guo-Ying Kao,Yi Xu,Ying Zhang et al.
Guo-Ying Kao et al.
Objective: This study investigates the role of miR-144-5p in doxorubicin (DOX)-induced heart failure and explores its potential mechanisms by targeting ACSM1 and inhibiting lipid peroxidation. ...
Biomarker-Based Models Utilizing the Albumin-Fibrinogen Ratio Effectively Predict Peritoneal Metastasis in Patients with Gastric Cancer: A Retrospective Study [0.03%]
基于生物标志物的模型利用白蛋白-纤维蛋白原比值有效预测胃癌患者的腹膜转移：一项回顾性研究
Chun-Yang Shang,Xue-Pu Sun,Xue-Song Dong et al.
Chun-Yang Shang et al.
Objective: Peritoneal carcinomatosis (PC) is a common pattern of recurrence in gastric cancer patients and is associated with a poor prognosis. This study aimed to evaluate the predictive value of the albumin-fibrinogen r...
Unraveling the Molecular Underpinnings: The Therapeutic Impact of Aerobic Exercise on Anxiety Disorders [0.03%]
解开分子机制：有氧运动对焦虑症的治疗作用
Yi-Qing Rao,Zi-Yu Zhou,Zi-Qi Yang et al.
Yi-Qing Rao et al.
Anxiety disorders, characterized by persistent apprehension, somatic symptoms and fatigue, are leading causes of disability worldwide. The burgeoning therapeutic potential of aerobic exercise has gained prominence as a leading non-pharmacol...
Association of Decreased Fecal Microbiota Akkermansia with Increased High-Sensitivity C-Reactive Protein Levels in Patients with Unstable Angina [0.03%]
冠状动脉不稳定型心绞痛患者肠道微生物Akkermansia菌减少与高敏C-反应蛋白升高有关联的一项横断面研究
Yuan-Fan Yuan,Ji-Yu Zhang,Jia-Hao Xu et al.
Yuan-Fan Yuan et al.
Background and objective: Inflammation plays a pivotal role in the progression of coronary artery disease (CAD). High-sensitivity C-reactive protein (hsCRP) serves as a well-established biomarker for assessing cardiovascu...
Targeting Calprotectin S100A8/A9 to Overcome AML Progression in DNMT3A-Mutant Cells [0.03%]
靶向CALPROTECTIN S100A8/A9以克服DNMT3A突变型急性髓系白血病细胞的进展
Xiao-Ya Cai,Gui-Qin Huang,Ye-Ming Zhou et al.
Xiao-Ya Cai et al.
Objective: To investigate the effects of calprotectin (S100A8/A9) on the biological activity of acute myeloid leukemia (AML) cells harboring a DNA methyltransferase 3A (DNMT3A) mutation and to explore the underlying molec...
Risk Factors for Lymph Node Metastasis in Stage pT1 Invasive Lung Adenocarcinoma [0.03%]
早期肺腺癌淋巴结转移的危险因素分析
Shou-Kang Li,Nai-Cheng Song,Quan Liu et al.
Shou-Kang Li et al.
Objective: To analyze the risk factors for lymph node metastasis (LNM) in patients with stage pT1 lung adenocarcinoma to select a more appropriate surgical option. ...
Aberrant Sialylation in Ovarian Cancer: Orchestrating Progression, Metastasis, and Therapeutic Hurdles [0.03%]
卵巢癌中唾液酸糖链组装的异常及其在肿瘤进展、转移和治疗中的作用机制探究
Yu-Xin Chen,Guang-Nian Zhao,Qing-Lei Gao
Yu-Xin Chen
Ovarian cancer (OC), a highly lethal gynaecological malignancy, is often diagnosed at advanced stages, resulting in a poor prognosis. Sialylation, an important form of glycosylation, significantly contributes to the progression of various s...