The Protective Effects of Quercetin on Ferritinophagy in Alcoholic-Induced Liver Iron Overload [0.03%]
槲皮素对酒精诱导的肝铁过载细胞 ferritinophagy 的保护作用
You Jin,Hong-Mei Zeng,Chan Peng et al.
You Jin et al.
Objective: Iron overload resulting from chronic alcohol consumption may aggravate liver damage, and the potential mechanisms involving ferritinophagic flux and the role of naturally occurring quercetin in alcohol-induced ...
Effect of Screw Distribution on Stability and Interfragmentary Strain of Lower Tibial Fractures: A Finite Element Analysis [0.03%]
螺钉分布对下胫骨骨折内固定稳定性及断端应力的影响：有限元分析
Huan Su,Huan Xiao,Jian-Jun Zhou et al.
Huan Su et al.
Objective: The aim of this study was to explore the influence of working length (determined by the screw position) on the stiffness and interfragmentary strain (IFS) of femoral locking compression plate (LCP) external fix...
Global, Regional, and National Burden of Pulmonary Arterial Hypertension from 1990 to 2021 and Projections to 2040: A Systematic Analysis of Incidence, Mortality, and Disability-Adjusted Life Years [0.03%]
1990年～2021年全球、区域和国家肺动脉高压的疾病负担及2040年前预测：系统性分析发病率、死亡率与伤残调整寿命年
Lin-Ling Yu,Ding-Sheng Jiang,Xiong Wang et al.
Lin-Ling Yu et al.
Objective: Pulmonary arterial hypertension (PAH) poses a growing global health challenge, yet comprehensive epidemiological data remain limited. This study aims to assess the burden of PAH from 1990 to 2021 and project tr...
ESE-1 Regulates CREB-Mediated PTEN Expression to Activate the PI3K/Akt Pathway and Promote High-Glucose-Induced Endothelial Cell Injury [0.03%]
ESE-1通过调节CREB介导的PTEN表达来激活PI3K/Akt信号通路并促进高糖诱导的内皮细胞损伤
Tao Liu,Jian-Jun Hu
Tao Liu
Objective: Endothelial dysfunction is a central contributor to the vascular complications observed in individuals with diabetes. cAMP response element-binding protein (CREB) plays a crucial role in mediating hyperglycemia...
Nintedanib Inhibits VEGF-Induced Neovascularization in Human Conjunctival Vascular Endothelial Cells [0.03%]
尼替尼布抑制血管内皮生长因子诱导的结膜血管内皮细胞新生血管生成作用研究
Yi Cheng,Tang-Rui Huang,Yi-Ke Yan et al.
Yi Cheng et al.
Objective: Conjunctival vascularization and fibroblasts are important factors leading to filtering bleb scarring after glaucoma filtering surgery. Previous studies have shown that nintedanib can inhibit the transformation...
mRNA Vaccines in Cancer Immunotherapy: Recent Advances, Clinical Translation, and Future Perspectives [0.03%]
癌症免疫治疗中的mRNA疫苗：近期进展、临床转化和未来展望
Silpa Suman Pati,Shrestha Dhal,Ritesh Pattnaik et al.
Silpa Suman Pati et al.
Cancer remains a leading global health burden. mRNA cancer vaccines, which are propelled by their rapid development, manufacturing flexibility, and proven efficacy against infectious diseases, have emerged as a transformative approach in ca...
Remimazolam-Remifentanil versus Propofol-Remifentanil for Spontaneous Ventilation During Fiberoptic Bronchoscopy: A Randomized Controlled Trial [0.03%]
用于纤维支气管镜检查的瑞米唑仑-雷莫司当与右美托咪定-雷莫司当维持自主呼吸全身麻醉的效果比较：一项随机对照临床试验
Jing-Hao Huang,Hui-Jin Huang,Hong-Xin Gao et al.
Jing-Hao Huang et al.
Objective: Optimizing sedation to minimize respiratory depression during fiberoptic bronchoscopy (FOB) presents an ongoing challenge. This trial compared the safety and efficacy of remimazolam-remifentanil versus propofol...
Novel Prognostic Scoring Systems for Severe CRS after Anti-CD19 CAR-T-Cells in Acute B-Lymphoblastic Leukemia [0.03%]
急性B淋巴细胞白血病CAR-T治疗后重度CRS和神经毒性的新型预后评分系统
Sha Ke,Tai-Yuan Zhang,Zhuo-Lin Wu et al.
Sha Ke et al.
Objective: To develop a novel prognostic scoring system for severe cytokine release syndrome (CRS) in patients with B-cell acute lymphoblastic leukemia (B-ALL) treated with anti-CD19 chimeric antigen receptor (CAR)-T-cell...
Differential Expression of ATP6V1D and Its Diagnostic Potential in IgA Nephropathy [0.03%]
ATP6V1D在IgA肾病中的差异表达及其诊断价值
Liang Peng,Lin Hu,Yi-Qun Peng et al.
Liang Peng et al.
Objective: IgA nephropathy (IgAN) is the most prevalent form of primary glomerular disease. However, its diagnosis is contingent on kidney biopsy. Therefore, noninvasive biomarkers are urgently needed for diagnosis. This ...
Xiaoke Decoction Inhibits COX-2-Mediated LDLr Pathway Dysfunction and Protects Renal Function in Diabetic Nephropathy Rats [0.03%]
消渴方通过抑制COX-2介导的LDL受体途径异常改善糖尿病肾病大鼠肾脏功能
Zhi-Qi Tang,Yuan-Xia Liu,Ling-Jia Tao et al.
Zhi-Qi Tang et al.
Objective: Traditional Chinese medicine exhibits positive therapeutic effects as a primary or adjunctive treatment for diabetic nephropathy (DN). This study aimed to evaluate the impact and mechanism of action of Xiaoke d...