Clinical and Genetic Characteristics of Patients with Early-Onset Diabetes Involving at Least Two Consecutive Generations: Whole-Exome Sequencing in Probands from 25 Pedigrees [0.03%]
早发糖尿病连续两代以上家系的临床及遗传特征分析：25个家系先证者的外显子组测序研究
Chun-Qiong Ran,Ying Su,Xiong Wang et al.
Chun-Qiong Ran et al.
Background: The molecular mechanisms of early-onset multigenerational diabetes remain unknown. This study aimed to investigate the clinical and genetic characteristics of early-onset diabetes involving at least two consec...
Inflammation-Related Factors S100A9 and TLR2 in Cardiomyocyte Hypertrophy [0.03%]
心肌细胞肥厚相关炎症因子S100A9和TLR2的研究
Ke-Jia Jin,Le Pan,Chen-Xing Huang et al.
Ke-Jia Jin et al.
Objective: The pathogenesis and progression of heart failure (HF) are governed by complex, interconnected biological pathways, with dysregulated immune responses and maladaptive cardiac remodeling playing central roles. A...
Identification of Immune-Related Ferroptosis Biomarkers in Diabetic Kidney Disease and Screening of Associated Inhibitors [0.03%]
糖尿病肾病中铁死亡相关生物标志物的鉴定及其潜在抑制剂的筛选
Nan-Nan Zhang,Yi Zhu,Qiu-Yan Huang et al.
Nan-Nan Zhang et al.
Objective: Immune infiltration and ferroptosis play pivotal roles in the progression of diabetic kidney disease (DKD). However, investigations of immune cell-related ferroptosis genes (ICRFGs) in the context of DKD are in...
Associations Between Gut Microbiota, Short-Chain Fatty Acids, and High-Salt Diet-Induced Hypertension in Rats [0.03%]
肠道微生物群、短链脂肪酸与高盐饮食诱导的大鼠高血压的关系
Lin Li,Sen-Jie Zhong,Hao Liang et al.
Lin Li et al.
Objective: Numerous studies have established a link between hypertension (HTN) and a high-salt diet (HSD). However, the precise mechanisms are still being investigated, with increasing evidence suggesting that HSD can alt...
Development and Validation of a Nomogram Prediction Model for Sepsis-Induced Coagulopathy: A Multicenter Retrospective Study [0.03%]
脓毒症凝血病预后 nomogram 预测模型的构建及验证——多中心回顾性研究
Wen-Hao Ma,Ze-Yu Yang,Xing-Xing Fan et al.
Wen-Hao Ma et al.
Objective: This study aimed to develop a prediction model to assess the risk of sepsis-induced coagulopathy (SIC) in sepsis patients. Methods: ...
Advances and Challenges in Adeno-Associated Virus Gene Therapy Applications of Localized Delivery Strategies [0.03%]
局部递送策略在腺相关病毒基因治疗应用中的进展与挑战
Jin-Hao Chen,Li-Jun Zhan,Cun-Ming Lv et al.
Jin-Hao Chen et al.
In recent years, adeno-associated viruses (AAVs) have emerged as leading vectors in gene therapy, with several FDA-approved treatments and ongoing clinical trials demonstrating their effectiveness in treating inherited retinal diseases, hem...
NEP1-40 Regulates the Development of Hippocampal Neural Stem Cells in Schizophrenic Mice [0.03%]
NEP1-40调节精神分裂症小鼠海马神经干细胞的发育
Yu Shao,Yan-Bo Liu,Dong-Kun Yu et al.
Yu Shao et al.
Objective: Schizophrenia is a complex neuropsychiatric disorder characterized by cognitive, affective, and behavioral abnormalities. Existing treatments have yielded limited effects on improving cognitive function. Recent...
Expert Consensus on Clinical Application of Implantable Biventricular Assist Devices [0.03%]
植入式双心室辅助装置的临床应用专家共识
Nian-Guo Dong,David D&#x;Alessandro,Jamshid Karimov et al.
Nian-Guo Dong et al.
While biventricular assist devices (BiVADs) remain underutilized in Western countries for biventricular heart failure (BHF), their application is expanding in China. This consensus synthesizes international guidelines, medical evidence, and...
miR-146a Regulates Neuroinflammation and Immune Cell Function in Neurodegenerative Diseases [0.03%]
miR-146a在神经退行性疾病中调节神经炎症和免疫细胞功能
Jia-Rui Xiong,Zi-Yi Yan,Meng-Qiong Shi et al.
Jia-Rui Xiong et al.
Neurodegenerative diseases (NDDs) are characterized primarily by progressive impairments in cognition, behavior, and memory. MicroRNAs (miRNAs) are abundantly expressed in the central nervous system and are vital for the normal function and...
Xi-Xi Yu,E Tian,Jun Wang et al.
Xi-Xi Yu et al.
Recent years have seen a burgeoning interest in elucidating the intricate relationship between vestibular dysfunction and sleep disorders, owing to their substantial impact on daily functioning and overall health. Despite significant advanc...