CD44v6 CAR-T Cells Target DNMT3A-Mutant AML: Synergistic Enhancement by Decitabine [0.03%]
靶向DNMT3A突变型急性髓系白血病的CD44v6 CAR-T细胞：地西他滨增强其疗效
Hui-Min Li,Yi-Mei Que,Xiao-Ya Cai et al.
Hui-Min Li et al.
Objective: Acute myeloid leukemia (AML) is a highly heterogeneous disease, and molecular events such as DNMT3A gene mutations are associated with poor prognosis in AML patients. Consequently, there is an urgent need for a...
Current Status and Advances in Anti-Androgen Therapy for Triple-Negative Breast Cancer [0.03%]
抗雄激素治疗三阴性乳腺癌的研究进展与现状分析
Jing-Bo Li,Wen-Fei Xia
Jing-Bo Li
The heterogeneity of triple-negative breast cancer (TNBC) has spurred the exploration of precision therapies based on molecular subtypes, with the androgen receptor (AR)-positive subtype emerging as a potential therapeutic target. The treat...
Clinicopathological and Molecular Characterization of Uterine Tumors Resembling Ovarian Sex Cord Tumors: An Eight-Case Series with Novel Fusion Gene Insights and Literature Review [0.03%]
类似卵巢性索肿瘤的子宫肿瘤的临床病理和分子特征：八例系列研究及文献回顾中的新型融合基因见解
Shu-Hao Yang,Dong Kuang,Ya Li et al.
Shu-Hao Yang et al.
Uterine tumors resembling ovarian sex cord tumors (UTROSCTs) are characterized by an uncertain malignant potential and exhibit prominent sex cord-like differentiation. The purpose of this study was to comprehensively review the clinicopatho...
Electroacupuncture Improves Gastrointestinal Motility in Rats with Functional Dyspepsia via the GDNF/GFRα1/PI3K/Akt Signaling Pathway [0.03%]
电针通过神经营养因子(GDNF)/GFRα1/PI3K/Akt信号通路改善功能性消化不良模型大鼠胃肠动力功能研究
Li Zhou,Xiao-Li Pan,De-Qian Yang et al.
Li Zhou et al.
Objective: Abnormal gastrointestinal motility plays a crucial role in the pathogenesis of functional dyspepsia (FD). Although electroacupuncture (EA) has demonstrated efficacy in FD treatment, its precise mechanism remain...
Artificial Intelligence in Traditional Chinese Medicine: Multimodal Fusion and Machine Learning for Enhanced Diagnosis and Treatment Efficacy [0.03%]
人工智能在中医中的应用：多模态融合和机器学习在中医诊断及治疗中的有效性研究
Jie Wang,Yong-Mei Liu,Jun Li et al.
Jie Wang et al.
Artificial intelligence (AI) serves as a key technology in global industrial transformation and technological restructuring and as the core driver of the fourth industrial revolution. Currently, deep learning techniques, such as convolution...
Yinchenhao Decoction Combined with Praziquantel Ameliorates Inflammation and Hepatic Fibrosis in Schistosoma japonicum-Infected Mice [0.03%]
茵陈蒿汤联合吡喹酮改善日本血吸虫感染小鼠的炎症和肝纤维化
Jia-Hua Liu,Mei Peng,Fang Chen et al.
Jia-Hua Liu et al.
Objective: This study aimed to investigate the therapeutic effects and underlying mechanisms of the combination of Yinchenhao decoction (YCHD) and praziquantel (PZQ) in a Schistosoma japonicum (S. japonicum)-induced mouse...
Physiological Reconstruction for Moderate-Severe Pelvic Organ Prolapse: A Multicenter Retrospective Self-Controlled Study [0.03%]
中重度盆腔器官脱垂生理重建的多中心回顾性自身对照研究
Zhen-Hua Gao,Xing-Qi Wang,Kun-Bin Ke et al.
Zhen-Hua Gao et al.
Objective: This is a self-controlled multicenter retrospective study based on the clinical efficacy and complications of physiological reconstruction in the treatment of moderate and severe pelvic organ prolapse. ...
Chop Deficiency Exacerbates Cyclophosphamide-Induced Overactive Bladder via Impaired Macrophage Apoptosis [0.03%]
缺氧诱导因子不足通过损害巨噬细胞凋亡加重环磷酰胺引起的过度活动膀胱症状
Ya-Nan Wang,Xiang-Dong Guo,Chun-Yu Zhang et al.
Ya-Nan Wang et al.
Objective: Overactive bladder, a storage syndrome characterized by urinary urgency, frequency, and nocturia with or without urgency urinary incontinence, severely affects the quality of life of patients. The aim of this s...
Anatomic Variations of the Lacrimal Sac Relative to Middle Turbinate Axilla and Skull Base in Chinese Patients with Nasolacrimal Duct Obstruction: A CT-Dacryocystography [0.03%]
中国鼻泪管阻塞患者泪囊解剖变异的CT- dacryo造影研究
Hui-Yang Ai,Xu-Hui Chen,Qi-Lan Hu et al.
Hui-Yang Ai et al.
Objective: The middle turbinate axilla (MTA) is a crucial anatomical landmark for localizing the lacrimal sac (LS) during endonasal dacryocystorhinostomy (En-DCR). Despite being a standard surgical procedure, En-DCR may l...
Circulating T Regulatory Cells Are Persistently Reduced in Non-Severe Acquired Aplastic Anemia [0.03%]
非重症获得性再生障碍性贫血患者的循环T调节细胞水平持续降低
Pasqualina Scala,Valentina Giudice,Denise Morini et al.
Pasqualina Scala et al.
Objective: Acquired aplastic anemia (aAA) is characterized by an autologous immunological attack against hematopoietic stem and progenitor cells, and immunotolerance disruption is frequent, with reduced T regulatory cells...