ESE-1 Regulates CREB-Mediated PTEN Expression to Activate the PI3K/Akt Pathway and Promote High-Glucose-Induced Endothelial Cell Injury [0.03%]
ESE-1通过调节CREB介导的PTEN表达来激活PI3K/Akt信号通路并促进高糖诱导的内皮细胞损伤
Tao Liu,Jian-Jun Hu
Tao Liu
Objective: Endothelial dysfunction is a central contributor to the vascular complications observed in individuals with diabetes. cAMP response element-binding protein (CREB) plays a crucial role in mediating hyperglycemia...
Nintedanib Inhibits VEGF-Induced Neovascularization in Human Conjunctival Vascular Endothelial Cells [0.03%]
尼替尼布抑制血管内皮生长因子诱导的结膜血管内皮细胞新生血管生成作用研究
Yi Cheng,Tang-Rui Huang,Yi-Ke Yan et al.
Yi Cheng et al.
Objective: Conjunctival vascularization and fibroblasts are important factors leading to filtering bleb scarring after glaucoma filtering surgery. Previous studies have shown that nintedanib can inhibit the transformation...
mRNA Vaccines in Cancer Immunotherapy: Recent Advances, Clinical Translation, and Future Perspectives [0.03%]
癌症免疫治疗中的mRNA疫苗：近期进展、临床转化和未来展望
Silpa Suman Pati,Shrestha Dhal,Ritesh Pattnaik et al.
Silpa Suman Pati et al.
Cancer remains a leading global health burden. mRNA cancer vaccines, which are propelled by their rapid development, manufacturing flexibility, and proven efficacy against infectious diseases, have emerged as a transformative approach in ca...
Remimazolam-Remifentanil versus Propofol-Remifentanil for Spontaneous Ventilation During Fiberoptic Bronchoscopy: A Randomized Controlled Trial [0.03%]
用于纤维支气管镜检查的瑞米唑仑-雷莫司当与右美托咪定-雷莫司当维持自主呼吸全身麻醉的效果比较：一项随机对照临床试验
Jing-Hao Huang,Hui-Jin Huang,Hong-Xin Gao et al.
Jing-Hao Huang et al.
Objective: Optimizing sedation to minimize respiratory depression during fiberoptic bronchoscopy (FOB) presents an ongoing challenge. This trial compared the safety and efficacy of remimazolam-remifentanil versus propofol...
Novel Prognostic Scoring Systems for Severe CRS after Anti-CD19 CAR-T-Cells in Acute B-Lymphoblastic Leukemia [0.03%]
急性B淋巴细胞白血病CAR-T治疗后重度CRS和神经毒性的新型预后评分系统
Sha Ke,Tai-Yuan Zhang,Zhuo-Lin Wu et al.
Sha Ke et al.
Objective: To develop a novel prognostic scoring system for severe cytokine release syndrome (CRS) in patients with B-cell acute lymphoblastic leukemia (B-ALL) treated with anti-CD19 chimeric antigen receptor (CAR)-T-cell...
Differential Expression of ATP6V1D and Its Diagnostic Potential in IgA Nephropathy [0.03%]
ATP6V1D在IgA肾病中的差异表达及其诊断价值
Liang Peng,Lin Hu,Yi-Qun Peng et al.
Liang Peng et al.
Objective: IgA nephropathy (IgAN) is the most prevalent form of primary glomerular disease. However, its diagnosis is contingent on kidney biopsy. Therefore, noninvasive biomarkers are urgently needed for diagnosis. This ...
Xiaoke Decoction Inhibits COX-2-Mediated LDLr Pathway Dysfunction and Protects Renal Function in Diabetic Nephropathy Rats [0.03%]
消渴方通过抑制COX-2介导的LDL受体途径异常改善糖尿病肾病大鼠肾脏功能
Zhi-Qi Tang,Yuan-Xia Liu,Ling-Jia Tao et al.
Zhi-Qi Tang et al.
Objective: Traditional Chinese medicine exhibits positive therapeutic effects as a primary or adjunctive treatment for diabetic nephropathy (DN). This study aimed to evaluate the impact and mechanism of action of Xiaoke d...
The Regulatory Mechanism of MicroRNA-144-3p on Damage to Endometrial Epithelial Cells Exposed to Copper Ions In Vitro [0.03%]
微 RNA - 144 - 3p 对铜离子体外损伤子宫内膜上皮细胞的调控机制研究
Xiao-Rong Fan,Hou-Ze Zhu,Meng-Ying Lei et al.
Xiao-Rong Fan et al.
Objective: To investigate the differential expression of microRNA-144-3p in endometrial cells exposed to copper ions in vitro. The specific mechanism by which microRNA-144-3p is involved in Cu2+-induced damage to the huma...
Multifunctional Roles and Therapeutic Prospects of C1q/TNF-Related Protein 3 (CTRP3) in Human Diseases [0.03%]
C1q肿瘤坏死因子相关蛋白3（CTRP3）在人类疾病中的多效性功能及治疗前景
Qing-Peng Wang,Chen Wang,Yan-Hong Yuan et al.
Qing-Peng Wang et al.
Adipokines, including C1q/tumor necrosis factor (TNF)-related proteins (CTRPs), adiponectin, TNF-α, and leptin, are crucial bioactive molecules that are secreted by adipose tissue and circulate in the bloodstream. To date, 15 members of th...
Konjac Oligosaccharide Alleviates Constipation in Mice via 5-HT4R/cAMP/PKA/p-CREB Pathway Activation [0.03%]
魔芋寡糖通过5-HT4R/cAMP/PKA/p-CREB信号途径缓解小鼠便秘 эффектIVENESS
Guang-Jun Sun,Ming Li,Xiao-Yu Zhang et al.
Guang-Jun Sun et al.
Background: Konjac oligosaccharide (KOS), which is produced through the degradation of konjac glucomannan via enzymatic, chemical, or physical treatments, has been found to have laxative effects. The current study aimed t...