Subsequent Pregnancy Outcomes After Conservative Treatment of Postpartum Hemorrhage Following Cesarean Delivery [0.03%]
Xiao-Xian Qu,Wen-Ting Zhou,Mark Landon et al.
Xiao-Xian Qu et al.
Objective: This study aimed to investigate pregnancy outcomes after conservative treatment for severe postpartum hemorrhage (PPH) following cesarean delivery (CD). ...
LATS1/2 Inhibitor Attenuates Osteoclast Differentiation via Hippo-YAP/TAZ Signaling Pathway and Alleviates Osteoporosis in Ovariectomized Rats [0.03%]
Si-Hui Chen,Yi Jiang,Guo-Qing Xie et al.
Si-Hui Chen et al.
Background: This study investigated the role and underlying mechanism of large tumor suppressor 1/2 (LATS1/2), a core kinase in the Hippo pathway, in inhibiting osteoclastic differentiation and ameliorating ovariectomy (O...
Zi-Yang Wang,Xiao-Fei Wu,Di-Yi Fu et al.
Zi-Yang Wang et al.
Over the past decade, adeno-associated virus (AAV) vectors have emerged as a powerful tool for in vivo gene transfer, owing to their diverse tissue tropisms, predominantly non-integrative property, and superior safety profile compared with ...
Efficacy and Mechanisms of Duhuo Jisheng Decoction in Treating Intervertebral Disc Degeneration: A Network Pharmacology and Experimental Study [0.03%]
Jing Feng,Lei Xu,Hong-Yan Miao et al.
Jing Feng et al.
Objective: Intervertebral disc degeneration (IDD) is the main cause of low back pain, which is closely related to an imbalance in extracellular matrix decomposition-anabolism mediated by immune inflammation. Duhuo Jisheng...
Matteo Guarino,Roberto De Giorgio
Matteo Guarino
Atrial fibrillation (AF) is a frequent arrhythmia in sepsis patients and is traditionally regarded as a harmful epiphenomenon requiring immediate correction. Its abrupt onset and association with adverse outcomes have driven clinicians to p...
UXS1 Knockdown Suppresses Cell Proliferation and Invasion in Hepatocellular Carcinoma by Inducing Ferroptosis via SLC7A11/GPX4 Pathway [0.03%]
通过SLC7A11 / GPX4途径诱导铁死亡抑制肝癌细胞增殖和侵袭以敲除UXS1
Jun Lv,Kang Han,Fu-Yuan Gan et al.
Jun Lv et al.
Objective: Identifying novel molecular drivers is crucial to improving therapeutic strategies for hepatocellular carcinoma (HCC). This study aimed to investigate the clinical significance and biological function of UDP-gl...
ATF6 Identification Sensitizes B-Cell Precursor Acute Lymphoblastic Leukemia Cells to Doxorubicin [0.03%]
ATF6鉴定使B细胞前体急性淋巴细胞白血病细胞对阿霉素敏感
Samira Rahimi,Bahman Zarandi,Rima Manafi Shabestari et al.
Samira Rahimi et al.
Objective: Activating transcription factor 6 (ATF6) is a part of the unfolded protein response (UPR) system, which plays an important role in regulating endoplasmic reticulum stress. The overexpression of ATF6 has been re...
Screening and Functional Validation of Common Key Genes in Hypertrophic Cardiomyopathy and Ischemic Cardiomyopathy [0.03%]
肥厚型心肌病和缺血性心肌病共有关键基因的筛选及功能验证
Ping Jiang,Kai-Shen Cao,Ya-Jiao Liu et al.
Ping Jiang et al.
Objective: Hypertrophic cardiomyopathy (HCM) and ischemic cardiomyopathy (ICM) are the most common main etiologies of heart failure (HF), which is also a leading cause of mortality and morbidity; however, the common mecha...
HLA-E as an Emerging Checkpoint and Biomarker in Personalized Cancer Immunotherapy [0.03%]
HLA-E在个性化癌症免疫治疗中的新兴检查点和生物标志物作用
Rajeswary Sanmugawil,Lhoshiny Parmeswaran,Nafisah Abdul Rahman et al.
Rajeswary Sanmugawil et al.
Human leukocyte antigen (HLA) molecules play a predominant role in cancer immunotherapy by harnessing the immune system's capacity to differentiate between healthy and malignant cells. Most human cell types express HLA class I molecules, wh...
Trehalose: A Promising Therapeutic Agent for Diverse Pathological Conditions [0.03%]
海藻糖：一种颇具潜力的治疗多种病理状况的药物
Mahboobeh Ghasemzadeh Rahbardar,Prashant Kesharwani,Amirhossein Sahebkar
Mahboobeh Ghasemzadeh Rahbardar
Trehalose, a naturally occurring disaccharide, is gaining recognition for its therapeutic potential across a wide range of disorders. This review highlights the increasing importance of trehalose in clinical research and its applications in...