Global trends and epidemiological shifts in gastrointestinal cancers: insights from the past four decades [0.03%]
胃肠癌的全球发展趋势及流行病学转变：过去四十年中的启示
Mengmeng Li,Sumei Cao,Rui-Hua Xu
Mengmeng Li
Background: The epidemiological profiles of gastrointestinal (GI) cancers vary across countries and over time, largely reflecting variations in risk factors and screening practices. We aimed to provide an overview of the ...
Immunosuppressive JAG2+ tumor-associated neutrophils hamper PD-1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells [0.03%]
卵巢癌中免疫抑制性JAG2+肿瘤相关中性粒细胞通过介导效应调节T细胞的分化阻碍PD-1阻断反应
Chenyang Wang,Moran Yang,Yujing Zhong et al.
Chenyang Wang et al.
Background: Tumor-associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs ...
Pan-cancer analysis shapes the understanding of cancer biology and medicine [0.03%]
泛癌症分析塑造了我们对癌症生物学和医学的理解
Xiaoping Cen,Yuanyuan Lan,Jiansheng Zou et al.
Xiaoping Cen et al.
Advances in multi-omics datasets and analytical methods have revolutionized cancer research, offering a comprehensive, pan-cancer perspective. Pan-cancer studies identify shared mechanisms and unique traits across different cancer types, wh...
Deletion of epithelial HKDC1 decelerates cellular proliferation and impairs mitochondrial function of tumorous epithelial cells thereby protecting from intestinal carcinogenesis [0.03%]
上皮HKDC1的删除可减缓肿瘤上皮细胞的增殖并损害其线粒体功能，从而防止肠癌的发生
Lea Järke,Saskia Weber-Stiehl,Kensuke Shima et al.
Lea Järke et al.
Targeted intracellular delivery of molecular cargo to hypoxic human breast cancer stem cells [0.03%]
缺氧的人类乳腺癌干细胞内的分子货物的靶向递送
Ashley V Makela,Anthony Tundo,Huiping Liu et al.
Ashley V Makela et al.
Whole-genome CRISPR-Cas9 knockout screens identify SHOC2 as a genetic dependency in NRAS-mutant melanoma [0.03%]
全基因组CRISPR-Cas9敲除筛选鉴定SHOC2为NRAS突变黑色素瘤的遗传依赖性
Andrea Y Gu,Tet Woo Lee,Aziza Khan et al.
Andrea Y Gu et al.
Comprehensive DSRCT multi-omics analyses unveil CACNA2D2 as a diagnostic hallmark and super-enhancer-driven EWSR1::WT1 signature gene [0.03%]
全面的DSRCT多组学分析揭示CACNA2D2作为诊断标志物以及超级增强子驱动的EWSR1::WT1特征基因
Florian Henning Geyer,Alina Ritter,Seneca Kinn-Gurzo et al.
Florian Henning Geyer et al.
Blocking ITGA5 potentiates the efficacy of anti-PD-1 therapy on glioblastoma by remodeling tumor-associated macrophages [0.03%]
阻断ITGA5通过改造肿瘤相关巨噬细胞增强anti-PD-1治疗胶质母细胞瘤的疗效
Rongrong Zhao,Ziwen Pan,Jiawei Qiu et al.
Rongrong Zhao et al.
Background: Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti-PD-1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti-PD-1 therap...
Reflections and insights into the evolution of restrictive eligibility criteria for cancer clinical trials in China and beyond [0.03%]
对中国及全球癌症临床试验限制性纳入标准演变的反思与见解
Huiyao Huang,Huilei Miao,Jinling Tang et al.
Huiyao Huang et al.
Rare germline ATM variants predispose to secondary cancer in chronic lymphocytic leukaemia patients [0.03%]
慢性淋巴细胞白血病患者中的稀有生殖系ATM变异体使其易患继发性癌症
Anna Petrackova,Jirina Manakova,Romana Nesnadna et al.
Anna Petrackova et al.