Adjuvant transcatheter arterial chemoembolization after curative resection for hepatocellular carcinoma patients with solitary tumor and microvascular invasion: a randomized clinical trial of efficacy and safety [0.03%]
术后介入治疗预防肝癌微血管侵犯的复发转移——随机对照研究
Wei Wei,Pei-En Jian,Shao-Hua Li et al.
Wei Wei et al.
Background: The optimal strategy for adjuvant therapy after curative resection for hepatocellular carcinoma (HCC) patients with solitary tumor and microvascular invasion (MVI) is controversial. This trial evaluated the ef...
Characterization of drug responses of mini patient-derived xenografts in mice for predicting cancer patient clinical therapeutic response [0.03%]
利用小类器官药物筛选预测癌症患者临床治疗反应
Feifei Zhang,Wenjie Wang,Yuan Long et al.
Feifei Zhang et al.
Background: Patient-derived organoids and xenografts (PDXs) have emerged as powerful models in functional diagnostics with high predictive power for anticancer drug response. However, limitations such as engraftment failu...
Development and validation of an endoscopic images-based deep learning model for detection with nasopharyngeal malignancies [0.03%]
基于内镜图像的深度学习模型在鼻咽癌检测中的研发与验证
Chaofeng Li,Bingzhong Jing,Liangru Ke et al.
Chaofeng Li et al.
Background: Due to the occult anatomic location of the nasopharynx and frequent presence of adenoid hyperplasia, the positive rate for malignancy identification during biopsy is low, thus leading to delayed or missed diag...
Snail promotes metastasis of nasopharyngeal carcinoma partly by down-regulating TEL2 [0.03%]
Snail通过下调TEL2部分促进鼻咽癌转移
Yi Sang,Chun Cheng,Yi-Xin Zeng et al.
Yi Sang et al.
Background: Metastasis is the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC). We previously reported that TEL2, a negative regulator of SERPINE1, could inhibit NPC metastasis to lymph nod...
Development of a novel method for rapid cloning of shRNA vectors, which successfully knocked down CD44 in mesenchymal triple-negative breast cancer cells [0.03%]
一种新型快速克隆shRNA载体的方法及其成功敲低间质型三阴性乳腺癌细胞CD44的表达
Lei Zhou,Dandan Sheng,Qiaodan Deng et al.
Lei Zhou et al.
Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells [0.03%]
乳腺癌干细胞表型由转录组多态性而非基因组多态性决定
Mengying Tong,Ziqian Deng,Mengying Yang et al.
Mengying Tong et al.
Background: Breast cancer stem cells (BCSCs) are considered responsible for cancer relapse and drug resistance. Understanding the identity of BCSCs may open new avenues in breast cancer therapy. Although several discoveri...
External validity of a prognostic nomogram for locoregionally advanced nasopharyngeal carcinoma based on the 8th edition of the AJCC/UICC staging system: a retrospective cohort study [0.03%]
基于AJCC / UICC第八版分期系统的局部区域晚期鼻咽癌预后预测列线图的外部有效性：一项回顾性队列研究
Pu-Yun OuYang,Kai-Yun You,Lu-Ning Zhang et al.
Pu-Yun OuYang et al.
Background: The tumor-node-metastasis (TNM) staging system does not perform well for guiding individualized induction or adjuvant chemotherapy for patients with locoregionally advanced nasopharyngeal carcinoma (NPC). We a...
Personalized treatment based on mini patient-derived xenografts and WES/RNA sequencing in a patient with metastatic duodenal adenocarcinoma [0.03%]
基于微型患者来源的异种移植和WES / RNA测序的个性化治疗在转移性十二指肠腺癌患者中的应用
Peng Zhao,Hui Chen,Danyi Wen et al.
Peng Zhao et al.
Background: Treatment guidelines for a variety of cancers have been increasingly used in clinical practice, and have resulted in major improvement in patient outcomes. However, recommended regimens (even first-line treatm...
Overexpression of amplified in breast cancer 1 (AIB1) gene promotes lung adenocarcinoma aggressiveness in vitro and in vivo by upregulating C-X-C motif chemokine receptor 4 [0.03%]
乳腺癌 amplified in breast cancer 1(AIB1)基因的过表达通过上调C-X-C基序趋化因子受体4促进肺腺癌的恶性表型
Liru He,Haixia Deng,Shiliang Liu et al.
Liru He et al.
Background: We previously found that overexpression of the gene known as amplified in breast cancer 1 (AIB1) was associated with lymph node metastasis and poor prognosis in patients with lung adenocarcinoma. However, the ...
Chao-Nan Qian,Francesco Pezzella
Chao-Nan Qian
The close relationship between metastasis and establishment of tumor vasculature has inspired enormous research interests aiming to suppress metastasis via inhibiting the development of tumor vasculature. International experts gathered in G...