The association between early-onset cardiac events caused by neoadjuvant or adjuvant chemotherapy in triple-negative breast cancer patients and some novel autophagy-related polymorphisms in their genomic DNA: a real-world study [0.03%]
三阴性乳腺癌患者因新辅助或辅助化疗导致早期发生心脏事件与基因组DNA中一些新的自噬相关多态性的关联：一项真实世界研究
Binliang Liu,Tao An,Meiying Li et al.
Binliang Liu et al.
Background: An increasing number of cancer patients die of cardiovascular diseases. The cardiotoxicity of chemotherapy is particularly important in triple-negative breast cancer (TNBC) with limited therapeutic options. Ca...
The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response [0.03%]
基因组学揭秘基底样小圆细胞瘤中与DNA损伤反应、上皮间质转化和免疫反应相关的失调基因
Andrea Devecchi,Loris De Cecco,Matteo Dugo et al.
Andrea Devecchi et al.
Background: Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive, and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1 (EWSR1)-...
The 150 most important questions in cancer research and clinical oncology series: questions 94-101 : Edited by Cancer Communications [0.03%]
肿瘤研究和临床肿瘤学系列重大问题之九十四个至一百零一个：《癌症》杂志编辑
Cancer Communications
Cancer Communications
Since the beginning of 2017, Cancer Communications (former title: Chinese Journal of Cancer) has published a series of important questions regarding cancer research and clinical oncology, to provide an enhanced stimulus for cancer research,...
A modified clinicopathological tumor staging system for survival prediction of patients with penile cancer [0.03%]
一种改良的临床病理肿瘤分期系统用于预测阴茎癌患者的生存率
Zai-Shang Li,Antonio Augusto Ornellas,Christian Schwentner et al.
Zai-Shang Li et al.
Background: The 8th American Joint Committee on Cancer tumor-node-metastasis (AJCC-TNM) staging system is based on a few retrospective single-center studies. We aimed to test the prognostic validity of the staging system ...
Proposal and validation of a modified staging system to improve the prognosis predictive performance of the 8th AJCC/UICC pTNM staging system for gastric adenocarcinoma: a multicenter study with external validation [0.03%]
改良版美国癌症联合委员会/国际抗癌联盟第8版胃腺癌pTNM分期系统及其预后预测效能的多中心研究及外部验证
Cheng Fang,Wei Wang,Jing-Yu Deng et al.
Cheng Fang et al.
Background: The 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) pathological tumor-node-metastasis (pTNM) staging system may have increased accuracy in predicting p...
Multicenter Study
Cancer communications (London, England). 2018 Nov 19;38(1):67. DOI:10.1186/s40880-018-0337-5 2018
Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study [0.03%]
一项关于帕菲替尼联合同期放化疗治疗局部晚期鼻咽癌的I期、开放性剂量递增研究
Qiuyan Chen,Linquan Tang,Na Liu et al.
Qiuyan Chen et al.
Background: Famitinib is a tyrosine kinase inhibitor against multiple targets, including vascular endothelial growth factor receptor 2/3, platelet-derived growth factor receptor, and stem cell factor receptor (c-kit). Pre...
Yugang Wang,Yan Xia,Zhimin Lu
Yugang Wang
Cancer cells uniquely reprogram their cellular activities to support their rapid proliferation and migration and to counteract metabolic and genotoxic stress during cancer progression. In this reprograming, cancer cells' metabolism and othe...
DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2 [0.03%]
DUXAP8通过表观遗传学抑制CDKN1A和KLF2促进胰腺癌细胞生长——一个来源于假基因的长链非编码RNA
Yifan Lian,Jiebin Yang,Yikai Lian et al.
Yifan Lian et al.
Background: Recent studies highlight pseudogene derived long non-coding RNAs (lncRNAs) as key regulators of cancer biology. However, few of them have been well characterized in pancreatic cancer. Here, we aimed to identif...
Sean Lu,Yugang Wang
Sean Lu
Metabolism is a fundamental biological process composed of a series of reactions catalyzed by metabolic enzymes. Emerging evidence demonstrates that the aberrant signaling in cancer cells induces nonmetabolic functions of metabolic enzymes ...
IL-2Rα up-regulation is mediated by latent membrane protein 1 and promotes lymphomagenesis and chemotherapy resistance in natural killer/T-cell lymphoma [0.03%]
IL-2Rα上调由潜伏膜蛋白1介导并促进自然杀伤T细胞淋巴瘤的淋巴瘤发生及化疗耐药性
Liang Wang,Xi-Wen Bi,Yu-Jia Zhu et al.
Liang Wang et al.
Background: Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive non-Hodgkin lymphoma often resistant to chemotherapy. Serum level of soluble IL-2 receptor α (IL-2Rα) is elevated in NKTCL patients and correlate...